Uveitis as an Open Window to Systemic Inflammatory Diseases

Jammal, Thomas El; Loria, Olivier; Jamilloux, Yvan; Gerfaud‐Valentin, Mathieu; Kodjikian, Laurent; Sève, P.

doi:10.3390/jcm10020281

Cited by 19 publications

(10 citation statements)

References 188 publications

(262 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Despite the common diagnosis of sarcoidosis, followed by HLA-B27-associated uveitis and then Behcet's disease (BD) (33,34), our study found BD to be the most common diagnosis, followed by ankylosing spondylitis (AS) and systemic lupus erythematosus (SLE). This divergence might be due to the high prevalence of BD reported in Syria, a silk road country (35), or it could re ect racial differences and sample size variation.…”

Section: Discussionmentioning

confidence: 58%

Characterizing Autoimmune Uveitis in Relation to Systemic Diseases: A Retrospective Study from a Syrian Tertiary Reference Center.

Kudsi,

Deeb,

Khalayli

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Uveitis, a notable cause of severe visual impairment, is frequently characterized as infectious or non-infectious autoimmune uveitis (AU), the latter of which is commonly associated with younger individuals and systemic diseases. Despite the condition's widespread impact, there are substantial gaps in the comprehension of its pathogenesis, clinical presentation, and therapeutic response, particularly concerning systemic disease-associated uveitis. Aim of the Study: The current study aims to bridge these gaps through an extensive examination of demographic and clinical features in AU patients, thereby informing future research, therapeutic strategies, and improving patient outcomes. Methods: This retrospective observational study analyzed 87 patients with systemic disease-associated uveitis from January 2018 to December 2022 in Damascus, Syria. With diagnoses made using the Standardization of Uveitis Nomenclature Working Group Criteria, the study evaluated tailored treatment efficacy at the 24-month post-treatment mark, alongside comprehensive ophthalmic examinations, laboratory evaluations, and radiographic assessments. Results: In our study included 87 patients with Systemic Disease-Associated Autoimmune Uveitis (SDA-AU). Women represented 64.36% of this group, and the mean age at diagnosis was 43.8 for women and 39.8 for men. The most reported symptom was a painful red eye (52.87%). The onset of symptoms was sudden for 32.18% of patients, while 67.81% reported gradual development. Complications occurred in 33.33% of patients, including cataracts (41.37% of those with complications) and glaucoma (17.24%). Laboratory evaluations showed elevated inflammation markers in 66.66% of patients. Upon the 24-month assessment, 48.27% of patients achieved complete remission, 37.93% showed significant improvement, while disease worsened in 13.79% of cases. Conclusion: Our findings demonstrated that the presentation of autoimmune uveitis in this cohort frequently precedes the diagnosis of systemic diseases, affirming the vital role of an early and accurate diagnosis of uveitis for the detection of underlying systemic conditions. In conclusion, our study underlines the significance of a comprehensive and multidisciplinary approach in the management of SD-AU, leading to improved prognosis and quality of life for patients.

show abstract

Section: Discussionmentioning

confidence: 58%

Characterizing Autoimmune Uveitis in Relation to Systemic Diseases: A Retrospective Study from a Syrian Tertiary Reference Center.

Kudsi,

Deeb,

Khalayli

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…En relación con el tratamiento, los medicamentos de elección al momento del diagnóstico fueron los medicamentos tópicos como esteroides, AINE tópicos, anticolinérgicos e inhibidores de la anhidrasa carbónica. Los esteroides sistémicos e inmunosupresores se dieron en un número más pequeño de pacientes, lo que habla de menos compromiso sistémico y casos severos 29 .…”

Section: Discussionunclassified

Caracterización epidemiológica de pacientes con uveítis en el suroccidente colombiano

Nieto-Aristizábal¹,

Delgado²,

Mosquera-Hernández³

et al. 2022

RSCO

View full text Add to dashboard Cite

Background: Ethnicity and geography have been described as determinants of the clinical presentation of uveitis and its etiology. Objective: To characterize patients from southwestern Colombia with uveitis. Material and methods: Retrospective study, from 2011 characteristics and outcomes of patients with uveitis were evaluated. Results: 144 patients were included. The age was 51.5 (35.2-61.7) years, 80 (55.5%) were women. 66% (n = 95) presented anterior uveitis. Of the clinical manifestations, the red eye was the most frequent, followed by ocular pain. Most had symptoms < 12 weeks, visual acuity of 20/20-20/40 and intraocular pressure ranges between 10-22 mmHg. Of the etiologies, 20 (17.9%) were still under study and 7 (6.3%) were undefined/idiopathic. Trauma was seen in 12 (10.7%), that associated with HLA-B27 in 10 (8.9%) and toxoplasmosis in 8 (7.1%). Conclusion: It is the first characterization of uveitis in southwestern Colombia.

show abstract

“…About 80 causes of uveitis have been described and these can be classified into four main groups. In Western countries, approximately one-quarter of cases are linked to ophthalmologic diseases, one-quarter to systemic diseases fulfilling consensual diagnostic criteria, one-quarter to presumed systemic diseases, and one-quarter have an unexplained origin [ 5 ]. Uveitis of unexplained origin, also known as idiopathic uveitis, represents 23–44% of cases according to recent studies [ 6 , 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of a Bayesian Network for Supporting the Etiological Diagnosis of Uveitis

Jamilloux

Romain-Scelle

Rabilloud

et al. 2021

JCM

Self Cite

View full text Add to dashboard Cite

The etiological diagnosis of uveitis is complex. We aimed to implement and validate a Bayesian belief network algorithm for the differential diagnosis of the most relevant causes of uveitis. The training dataset (n = 897) and the test dataset (n = 154) were composed of all incident cases of uveitis admitted to two internal medicine departments, in two independent French centers (Lyon, 2003–2016 and Dijon, 2015–2017). The etiologies of uveitis were classified into eight groups. The algorithm was based on simple epidemiological characteristics (age, gender, and ethnicity) and anatomoclinical features of uveitis. The cross-validated estimate obtained in the training dataset concluded that the etiology of uveitis determined by the experts corresponded to one of the two most probable diagnoses in at least 77% of the cases. In the test dataset, this probability reached at least 83%. For the training and test datasets, when the most likely diagnosis was considered, the highest sensitivity was obtained for spondyloarthritis and HLA-B27-related uveitis (76% and 63%, respectively). The respective specificities were 93% and 54%. This algorithm could help junior and general ophthalmologists in the differential diagnosis of uveitis. It could guide the diagnostic work-up and help in the selection of further diagnostic investigations.

show abstract

Uveitis as an Open Window to Systemic Inflammatory Diseases

Cited by 19 publications

References 188 publications

Characterizing Autoimmune Uveitis in Relation to Systemic Diseases: A Retrospective Study from a Syrian Tertiary Reference Center.

Characterizing Autoimmune Uveitis in Relation to Systemic Diseases: A Retrospective Study from a Syrian Tertiary Reference Center.

Caracterización epidemiológica de pacientes con uveítis en el suroccidente colombiano

Development and Validation of a Bayesian Network for Supporting the Etiological Diagnosis of Uveitis

Contact Info

Product

Resources

About