Uveitis associated with Mycoplasma pneumoniae meningitis

Yashar, Sharam S.; Yashar, Bahram; Epstein, E. J.; Viani, Rolando M.

doi:10.1034/j.1600-0420.2001.079001100.x

Cited by 15 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All the extrapulmonary disease manifestations listed in Table 9 are seldom [166-174]. In patients with arthritis, Mycoplasma pneumoniae was detected in the synovial fluid by PCR [171], which is an indication of a direct relationship to infection.…”

Section: Bartonellosismentioning

confidence: 99%

Chronic Lyme Disease and Co-infections: Differential Diagnosis

Berghoff¹

2012

TONEUJ

View full text Add to dashboard Cite

In Lyme disease concurrent infections frequently occur. The clinical and pathological impact of co-infections was first recognized in the 1990th, i.e. approximately ten years after the discovery of Lyme disease. Their pathological synergism can exacerbate Lyme disease or induce similar disease manifestations. Co-infecting agents can be transmitted together with Borrelia burgdorferi by tick bite resulting in multiple infections but a fraction of co-infections occur independently of tick bite. Clinically relevant co-infections are caused by Bartonella species, Yersinia enterocolitica, Chlamydophila pneumoniae, Chlamydia trachomatis, and Mycoplasma pneumoniae. In contrast to the USA, human granulocytic anaplasmosis (HGA) and babesiosis are not of major importance in Europe. Infections caused by these pathogens in patients not infected by Borrelia burgdorferi can result in clinical symptoms similar to those occurring in Lyme disease. This applies particularly to infections caused by Bartonella henselae, Yersinia enterocolitica, and Mycoplasma pneumoniae. Chlamydia trachomatis primarily causes polyarthritis. Chlamydophila pneumoniae not only causes arthritis but also affects the nervous system and the heart, which renders the differential diagnosis difficult. The diagnosis is even more complex when co-infections occur in association with Lyme disease. Treatment recommendations are based on individual expert opinions. In antibiotic therapy, the use of third generation cephalosporins should only be considered in cases of Lyme disease. The same applies to carbapenems, which however are used occasionally in infections caused by Yersinia enterocolitica. For the remaining infections predominantly tetracyclines and macrolides are used. Quinolones are for alternative treatment, particularly gemifloxacin. For Bartonella henselae, Chlamydia trachomatis, and Chlamydophila pneumoniae the combination with rifampicin is recommended. Erythromycin is the drug of choice for Campylobacter jejuni.

show abstract

Section: Bartonellosismentioning

confidence: 99%

Chronic Lyme Disease and Co-infections: Differential Diagnosis

Berghoff¹

2012

TONEUJ

View full text Add to dashboard Cite

show abstract

“…For example, the association between rubella and Fuch heterochromic cyclitis has been well documented. 36,[48][49][50][51][52][53][54][55][56][57][58][59][60][61][62] De Groot-Mijnes et al, 63 recently applied these novel molecular techniques to detect pathogens in patients with idiopathic uveitis, both anterior and posterior. [45][46][47] Other pathogens, including EBV, Mycoplasma pneumonia, Tropheryma whippelii, Chlamydia species, Leptospirosis, Mycobacterium leprae, Dengue fever, West Nile, and Chikungunya, have been implicated in the pathogenesis of anterior uveitis but their causal relationship has not been confirmed.…”

Section: ' Novel Pathogensmentioning

confidence: 99%

Current Diagnostic Approaches to Infectious Anterior Uveitis

Hunter

Lobo²

2011

International Ophthalmology Clinics

View full text Add to dashboard Cite

“…Several cases also have been reported in patients found to have edema of the optic papilla or anterior uveitis. 4 There are also studies that have reported finding retinal inflammation and circulatory disorders, including a case with panuveitis accompanied by retinal hemorrhage, 6 and a case with frosted branch angiitis and macular edema. 5 The inflammation and hemorrhage in both cases were mild, with no decrease in the final visual acuity observed.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, ocular inflammation associated with Mycoplasma pneumoniae infections in humans has been reported. [4][5][6] In several other cases, mycoplasmas have been suggested to have the ability to cause ocular inflammation. One of the remarkable infection routes reported for mycoplasma involves transplanta-tion surgery in which mycoplasma from a donor ends up causing an infection in the transplant recipient.…”

mentioning

confidence: 99%

Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells

Makabe

Sugita

Hono

et al. 2019

Invest. Ophthalmol. Vis. Sci.

View full text Add to dashboard Cite

PURPOSE. To report occurrence of acute severe inflammation after surgical implantation of mycoplasma-infected induced pluripotent stem cell-derived RPE (iPS-RPE) cells into the eyes of healthy primates, and determine the immunopathological mechanisms of the inflammation. METHODS.Ophthalmic allogeneic transplantation of iPS-RPE cells was performed in the subretina of major histocompatibility complex (MHC)-matched (two eyes) and MHCmismatched (one eye) healthy cynomolgus monkeys. The clinical course after transplantation was observed using color fundus photography, fluorescence angiography, and optical coherence tomography. After the animals were killed at 1 month after surgery, eyeballs were removed and pathologically examined. Microorganisms were analyzed by PCR methods and BLAST analysis using preserved graft iPS-RPE cells and the recipients' vitreous humor. Mixed lymphocyte-RPE assay was performed on the mycoplasma-infected and noninfected iPS-RPE cells in vitro. RESULTS.In tested eyes, abnormal findings were observed in the grafted retina 2 weeks after surgery. Here, we observed retinal vasculitis and hemorrhage, retinal detachment, and infiltration of inflammatory cells into the retina of the eyes. One month after surgery, animals were killed due to the severe immune responses observed. Using PCR methods, sequence analysis detected mycoplasma-DNA (Mycoplasma arginini species) in both the grafted RPE cells and the collected vitreous fluids of the monkeys. Mixed lymphocyte-RPE assay revealed that the infected iPS-RPE cells enhanced the proliferation of inflammatory cells in vitro. CONCLUSIONS.Transplantation of graft iPS-RPE cells contaminated with mycoplasma into the subretina caused severe ocular inflammation. Mycoplasma possesses the ability to cause immune responses in the host.

show abstract

Uveitis associated with Mycoplasma pneumoniae meningitis

Cited by 15 publications

References 10 publications

Chronic Lyme Disease and Co-infections: Differential Diagnosis

Chronic Lyme Disease and Co-infections: Differential Diagnosis

Current Diagnostic Approaches to Infectious Anterior Uveitis

Mycoplasma Ocular Infection in Subretinal Graft Transplantation of iPS Cells-Derived Retinal Pigment Epithelial Cells

Contact Info

Product

Resources

About