Uveitis in spondyloarthritis including psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease

Rosenbaum, James T.

doi:10.1007/s10067-015-2960-8

Cited by 103 publications

(59 citation statements)

References 27 publications

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“…36 Typical attacks are abrupt and unilateral, with intense circumlimbal hyperemia, pain, photophobia, and visual impairment. Subsequent attacks may involve the contralateral eye.…”

Section: Extra-articular Manifestationsmentioning

confidence: 99%

Ankylosing Spondylitis and Axial Spondyloarthritis

2016

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C hronic back pain is common worldwide and is cared for by a variety of providers, but specific, satisfactory treatment is often lacking. Ankylosing spondylitis, an inflammatory disorder that in its extreme form can lead to the bony fusion of vertebral joints, is an uncommon but well-established cause of chronic back pain. During the past decade, ankylosing spondylitis has come to be considered as a subset of the broader and more prevalent diagnostic entity referred to as axial spondyloarthritis. The estimated prevalence of axial spondyloarthritis in the United States is 0.9 to 1.4% of the adult population, similar to that of rheumatoid arthritis. 1 Axial spondyloarthritis is generally diagnosed and treated by rheumatologists, and there is specific treatment for it. However, prolonged delay in reaching the diagnosis is common and is usually the result of the failure of recognition by nonrheumatologists. 2 This review is intended to enhance awareness and understanding of axial spondyloarthritis and ankylosing spondylitis -and the relationship between the two -in order to facilitate prompt and accurate diagnosis and proper treatment. Recent advances in our understanding and treatment of these conditions are discussed.Concep t ua l His t or y a nd Cl a ssific ation

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“…36 Typical attacks are abrupt and unilateral, with intense circumlimbal hyperemia, pain, photophobia, and visual impairment. Subsequent attacks may involve the contralateral eye.…”

Section: Extra-articular Manifestationsmentioning

confidence: 99%

Ankylosing Spondylitis and Axial Spondyloarthritis

2016

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“…In AS, the visual prognosis after acute AU is excellent with adequate treatment, which usually includes topical (and at times oral and locally injected) corticosteroids 4. Observational studies have suggested that sulfasalazine (SSZ) may prevent recurrence of AU in patients with AS5 6 and some positive data also exist for methotrexate (MTX)7 and non-steroidal anti-inflammatory drugs (NSAID) 8.…”

Section: Introductionmentioning

confidence: 99%

Tumour necrosis factor inhibitor treatment and occurrence of anterior uveitis in ankylosing spondylitis: results from the Swedish biologics register

et al. 2017

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“…These associations are not surprising as comorbidities of some of these conditions are well recognised in the context of IBD 283– 285 and because almost all are associated with an increased incidence of similar pathologies such as arthritis 286 , uveitis 287, 288 and bowel inflammation 289– 292 .…”

Section: Identifying the Molecular Cause/s Of The CD Phenotypementioning

confidence: 99%

Making sense of the cause of Crohn’s – a new look at an old disease

Segal

2016

F1000Res

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The cause of Crohn’s disease (CD) has posed a conundrum for at least a century. A large body of work coupled with recent technological advances in genome research have at last started to provide some of the answers. Initially this review seeks to explain and to differentiate between bowel inflammation in the primary immunodeficiencies that generally lead to very early onset diffuse bowel inflammation in humans and in animal models, and the real syndrome of CD. In the latter, a trigger, almost certainly enteric infection by one of a multitude of organisms, allows the faeces access to the tissues, at which stage the response of individuals predisposed to CD is abnormal. Direct investigation of patients’ inflammatory response together with genome-wide association studies (GWAS) and DNA sequencing indicate that in CD the failure of acute inflammation and the clearance of bacteria from the tissues, and from within cells, is defective. The retained faecal products result in the characteristic chronic granulomatous inflammation and adaptive immune response. In this review I will examine the contemporary evidence that has led to this understanding, and look for explanations for the recent dramatic increase in the incidence of this disease.

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Uveitis in spondyloarthritis including psoriatic arthritis, ankylosing spondylitis, and inflammatory bowel disease

Cited by 103 publications

References 27 publications

Ankylosing Spondylitis and Axial Spondyloarthritis

Ankylosing Spondylitis and Axial Spondyloarthritis

Tumour necrosis factor inhibitor treatment and occurrence of anterior uveitis in ankylosing spondylitis: results from the Swedish biologics register

Making sense of the cause of Crohn’s – a new look at an old disease

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