UVEITIS INA RHEUMATOLOGISTS PRACTICE: A ROLE OF TUMOR NECROSIS FACTOR-а INHIBITORS

Моисеев, Сергей Валентинович

doi:10.14412/1996-7012-2009-577

Modern Rheumatology Journal

2009

DOI: 10.14412/1996-7012-2009-577

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UVEITIS INA RHEUMATOLOGISTS PRACTICE: A ROLE OF TUMOR NECROSIS FACTOR-а INHIBITORS

Сергей Валентинович Моисеев¹

Abstract: Uveitis frequently develops in patients with ankylosing spondylitis (AS) and other autoimmune diseases. It is occasionally characterized by a severe recurrent course and untreatable with systemic glucocorticoids (GC) and standard immunosuppressive agents. The results of (mainly small) clinical trials, as well as some observations suggest that therapy with tumor necrosis factor-α (TNF-α) inhibitors is effective in such

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Autoimmune Uveitis. Review

et al. 2019

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For many years in ophthalmology there is a complex intractable problem associated with inflammation of the vascular membrane of the eye, the so-called uveitis. Experts around the world are trying to understand this heterogeneous pathology of the visual organ, in a short time, which can lead to a sharp decrease in visual acuity, the development of severe complications and further disability. The number of patients with inflammation of the vascular tract is growing rapidly every year, the age is younger. The clinical picture of this pathology has changed slightly. Often began to manifest itself in two radically different directions. It proceeds as a sluggish form or vice versa manifests itself more aggressively with the rapid development of clinical manifestations in a short time. Currently, there is evidence of endogenous causes of uveitis.The article provides a review of the literature summarizing modern views on the problem of autoimmune uveitis. New factors affecting the etiology, pathogenesis of the disease, some aspects of therapy are considered. In addition, the main experimental models of autoimmune diseases of the vascular tract of the eye are analyzed.

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Autoimmune Uveitis. Review

et al. 2019

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Onset of Rheumatoid Arthritis with eye manifestations (clinical case report)

Akulova,

Avakian,

Dolishniaia

et al. 2024

Medicinskij alfavit

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Objective. Rheumatoid Arthritis may onset with ocular manifestations. The purpose of our work was presentation of clinical case of the onset of rheumatoid arthritis with an eye lesion.Materials and methods. A clinical case of rheumatoid arthritis with an atypical onset was analyzed. As well, a search and review of relevant literature was performed.Results. Patient with rheumatoid arthritis got bilateral ulcerous keratitis, refractory to conventional treatment and complicated by bilateral corneal perforation with iris prolapse. Due to the atypical clinical course of ophthalmic lesions being insusceptible of medical treatment, the patient was examined further. Laboratory immunological workup revealed positive rheumatoid factor, anti-CCP and anti-MCV antibodies. The typical symmetric presentation of arthritis developed 8 months after the onset of ophthalmic disorders. Baseline therapy of rheumatoid arthritis has demonstrated efficacy both in controlling the joint manifestations and preventing relapse of keratitis.Conclusion. The development of eye syndrome may precede articular manifestation of rheumatoid arthritis. While managing patients with recurrent bilateral keratitis, rheumatologic pathology should be suspected.

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UVEITIS INA RHEUMATOLOGISTS PRACTICE: A ROLE OF TUMOR NECROSIS FACTOR-а INHIBITORS

Cited by 2 publications

References 21 publications

Autoimmune Uveitis. Review

Autoimmune Uveitis. Review

Onset of Rheumatoid Arthritis with eye manifestations (clinical case report)

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