Background
Chinese medicine taking is an important link to ensure rational medicine use, and prescription matching can excavate more information on medicine use. traditional Chinese medicine (TCM) prescription data feature relationship is complex and multi-dimensional, and the prescription similarity matching model suffers from single attribute quantification, lack of elemental relationships, and the similarity of efficacy and primary function cannot be quantified, which brings challenges to the quantification of prescription similarity.
Methods
The focus of this study is to construct a framework for matching traditional Chinese medicine prescriptions with classic formulae, which integrates multiple features (MFTCMC) and explores the classic formulae contained in prescriptions to provide references for the medication-taking behavior of clinical traditional Chinese medicine prescriptions. Firstly, the prescription compatibility weight is calculated through Analytic Hierarchy Process (AHP), and the various dosage weights of herbs are integrated to construct a comprehensive weighting method, which selects a set of key herbs to form a core prescription. Secondly, the performance features of the core prescription are quantified by using the attribute labeling strategy of Chinese medicine properties. Finally, the relationship features of the core prescription are extracted by using a Bidirectional Long Short-Term Memory Network (BiLSTM), and the vector representation similarity matrix is constructed by combining the Siamese network framework. The matching score between the core prescription and the classic formula is calculated through a fully connected layer, and the traditional medication method of the matched classic formula is selected to provide references for the medication behavior of clinical prescriptions.
Results
Based on the prescription matching dataset constructed in this paper, the precision and F1 value reached 94.45% and 94.34% respectively, which is a significant improvement compared to several other models.
Conclusions
Compared with other models, the proposed MFTCMCF can effectively improve the performance of matching between prescriptions and classic formulae, and the results are more in line with the clinical practice of traditional Chinese medicine. This further improves the medication behavior of clinical prescriptions and provides new insights for research on recommended methods of taking traditional Chinese medicine prescriptions.