Aim: Hospital acquired infections are a serious problem in inpatients in terms of mortality and cost. The aim of this study is to present hospital acquired infections and risk factors, causative pathogens, antibiotic resistance status, and mortality relationship in a public hospital intensive care unit (ICU) over the scope of 5-years.Methods: Hospital acquired infections developed between January 2016 and December 2020 in Bolu İzzet Baysal State Hospital Adult ICUs were investigated retrospectively. Samples taken from areas such as central venous catheter, deep tracheal aspirate, urinary catheter and wound area were studied. Hospital acquired infections was diagnosed based on Centers for Disease and Control (CDC) criteria.Results: A total of 3587 patients were admitted to the ICUs between January 2016 and December 2020, and 309 (8.6%) patients were diagnosed with hospital acquired infections. When considered as comorbidity, neurological disorders were the most common, while sepsis was the most common hospitalization diagnosis in patients with hospital infection. The most common hospital acquired infections was ventilator associated pneumonia (VAP) with 38.8% (n=120) of the patients. Examining the culture isolate results, the most isolated agent as hospital acquired infections was Acinetobacter spp. (32.6%, n=101). Acinetobacter spp. and Klebsiella spp. It was resistant to all antibiotics with 4.9%.Conclusion: Hospital acquired infections rates may vary in intensive care units due to reasons such as awareness, physical conditions, education of working personnel, etc. Knowing the risk factors well, early culture isolate monitoring in suspected cases and selecting the appropriate antibiotic are effective in patient treatment and may reduce mortality.