(v) Epidemiology of bone &amp; soft tissue sarcomas

Beckingsale, Thomas B.; Shaw, C.

doi:10.1016/j.mporth.2015.03.001

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…Also, the risk of soft tissue cancer in immunocompromised people (acquired or congenital), is higher than others with a normal immune system. 10 …”

Section: Introductionmentioning

confidence: 99%

“…Also, the risk of soft tissue cancer in immunocompromised people (acquired or congenital), is higher than others with a normal immune system. 10 The share of bone cancer cases in mortality is disproportionately high among adolescents and young people in the age of 15 to 24 years. In developed countries, including the United States and the United Kingdom, primary bone tumors are the third common cause of death from cancer among people of young age after leukemia and central nervous system cancer.…”

Section: Introductionmentioning

confidence: 99%

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Incidence and Temporal Variations of Bone and Soft Tissue Cancers in the Golestan Province, Northern Iran, 2004–2016

Soghi,

Aarabi,

Sedaghat

et al. 2023

Arch Iran Med

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Background: This study was conducted to evaluate the epidemiological features of bone and soft cancers in the Golestan province, Northern Iran from 2004 to 2016. Methods: This is a descriptive cross-sectional study. All patients with primary bone and soft tissue cancers between 2004 and 2016 were included. Data were obtained from Golestan population-based cancer registry (GPCR). We calculated age-standardized incidence rates (ASRs) and reported the rates per 100000 person-year. Estimated annual percent change (EAPC) was also calculated to assess temporal trends in incidence rates of these cancers. Results: The ASRs of bone cancers and soft tissue cancers were 1.33 and 1.43 per 100000 person-year, respectively. This study also showed that the ASR of bone cancer was higher in men (1.51) than women (1.15). The ASR of soft tissue cancers in the urban population (1.58) was higher than rural (1.27), and was lower in women (1.37) than men (1.49). Two peaks were seen in the incidence of bone cancer. The first peak was in the age group of 10 to 20 years and the second was in patients over 60. We did not find significant temporal trends in the incidence of bone (EAPC=-1.14; P>0.05) and soft tissue cancers (EAPC=-2.73; P>0.05) during the study period. Conclusion: Epidemiological features of bone and soft tissue cancers including gender, age and place of residence should be considered by health policy makers in designing cancer control programs.

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“…Also, the risk of soft tissue cancer in immunocompromised people (acquired or congenital), is higher than others with a normal immune system. 10 …”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence and Temporal Variations of Bone and Soft Tissue Cancers in the Golestan Province, Northern Iran, 2004–2016

Soghi,

Aarabi,

Sedaghat

et al. 2023

Arch Iran Med

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“…Benign bone tumors are more common than malignant bone tumors and they are mostly seen in children and young adults (5).…”

Section: Introductionmentioning

confidence: 99%

The Evaluation of Musculoskeletal System Tumors and Tumor-Like Lesions in Thrace Region

Şenyiğit¹,

Söyleyici²,

İşkan³

et al. 2018

tmsj

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Aims: The aim of this study is to evaluate the data belonging to patients who were diagnosed with benign or malignant soft tissue and bone tumors and tumor-like lesions evaluated by musculoskeletal tumor study group of Trakya University Faculty of Medicine in between January 2013 and June 2017 and the relationship between the frequency of benign, malignant bone and soft tissue tumors and tumor-like lesions, with the patients' age and gender. Methods: The data of 687 patients who were evaluated by the musculoskeletal tumor study group of Trakya University Faculty of Medicine between January 2013-June 2017 were analyzed retrospectively. All of the data was analyzed by using SPSS. Chi-square analysis was used to obtain categorical data in order to point out the distribution of age and gender of patients with musculoskeletal system tumors and tumor-like lesions. Results: The number of patients over the period from January 2013 to June 2017 was 687. The number of patients who were evaluated by biopsy and acquired histopathologic confirmation of their condition was 341. The mean of patients' ages was 44.3±21.4 (4-92). Among 341 patients, 106 (47.1%) patients were female and 119 (52.9%) patients were male. The mean of females' ages was 43.7±20.4 (4-92). The mean of males' ages was 44.7±22.4 (5-90). Conclusion: Benign bone and soft tissue tumors were more common than malignant tumors. Benign bone tumors were predominantly seen in young adults. Our results was consistent with the literature however due to some patients who did not need a pathological sampling, our sample size was smaller than intended. With better archived information, more consistent results could be obtained in further studies.

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The Circulating Nucleic Acid Characteristics of Non-Metastatic Soft Tissue Sarcoma Patients

Eastley

Sommer

Ottolini

et al. 2020

IJMS

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Soft tissue sarcomas (STS) are rare, malignant tumours with a generally poor prognosis. Our aim was to explore the potential of cell free DNA (cfDNA) and circulating tumour DNA (ctDNA) analysis to track non-metastatic STS patients undergoing attempted curative treatment. The analysed cohort (n = 29) contained multiple STS subtypes including myxofibrosarcomas, undifferentiated pleomorphic sarcomas, leiomyosarcomas, and dedifferentiated liposarcomas amongst others. Perioperative cfDNA levels trended towards being elevated in patients (p = 0.07), although did not correlate with tumour size, grade, recurrence or subtype, suggesting a limited diagnostic or prognostic role. To characterise ctDNA, an amplicon panel covering three genes commonly mutated in STSs was first trialled on serial plasma collected from nine patients throughout follow-up. This approach only identified ctDNA in 2.5% (one in 40) of the analysed samples. Next custom-designed droplet digital PCR assays and Ion AmpliSeq™ panels were developed to track single nucleotide variants identified in patients’ STSs by whole exome sequencing (1–6 per patient). These approaches identified ctDNA in 17% of patients. Although ctDNA was identified before radiologically detectable recurrence in two cases, the absence of demonstrable ctDNA in 83% of cases highlights the need for much work before circulating nucleic acids can become a useful means to track STS patients.

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(v) Epidemiology of bone & soft tissue sarcomas

Cited by 3 publications

References 17 publications

Incidence and Temporal Variations of Bone and Soft Tissue Cancers in the Golestan Province, Northern Iran, 2004–2016

Incidence and Temporal Variations of Bone and Soft Tissue Cancers in the Golestan Province, Northern Iran, 2004–2016

The Evaluation of Musculoskeletal System Tumors and Tumor-Like Lesions in Thrace Region

The Circulating Nucleic Acid Characteristics of Non-Metastatic Soft Tissue Sarcoma Patients

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