V‐N‐C catalysts anchored to mesoporous Al‐SBA‐15 with tailorable pore sizes for the synthesis of spirooxindole dihydroquinazolinones derivatives

Abstract

Heterogeneous nanoscale catalyst was successfully synthesized via anchoring of V‐bis(2‐aminobenzamide) complex on the Al‐SBA‐15. This modified mesoporous was identified by several characterization techniques, such as X‐ray diffraction, field emission‐scanning electron microscopy, Fourier transform‐infrared, Brunauer–Emmett–Teller and transmission electron microscopy. V‐Bis(2‐aminobenzamide)@Al‐SBA‐15 was found to be an efficient heterogeneous catalyst for the rapid and desirable synthesis of various spirooxindole dihydroquinazolinones derivatives. In addition, the heterogeneous nanocatalyst was chemically stabilized in organic and aqueous solutions as well as can be expeditiously reused for at least seven cycles without a significant loss in catalytic activity.

Synthesis, Docking and In Vitro Evaluation of Spiroindoline‐3,2’‐Quinazoline Derivatives

“…The spiro derivatives of quinazoline are commonly prepared either via a 3-component reaction of isatoic anhydride, amine and cyclic ketone [19][20][21][22][23] or the reaction of 2-aminobenzamide with cyclic ketone. [24][25][26][27][28][29][30][31][32][33] In general, isatin has been used as the cyclic ketone or one of the ketones among various ketone derivatives employed in these reactions to afford the spiroindoline-3,2'-quinazoline derivatives.…”

Lubricant hydrogenation over a functionalized clay‐based Pd catalyst: A combined computational and experimental study

“…The ligand used for the functionalization of HNT was prepared according to the previous report. [ 54 ] Same as before, the reaction is a nucleophilic substitution, with the difference that in this work the amine takes the role of the nucleophile. Typically, an aqueous solution of DAP (3 mmol in 10‐ml deionized water) was prepared and mixed with a solution of IS in EtOH (6 mmol in 40 ml).…”

Facile synthesis of pyrazolopyridine pharmaceuticals under mild conditions using an algin-functionalized silica-based magnetic nanocatalyst (Alg@SBA-15/Fe3O4)

“…13 Mesoporous materials were rst discovered by Mobil Research and Development Corporation in 1992, and their synthesis and application have received great attention since then. 14 Zhao and coworkers at the University of California, Santa Barbara reported the SBA-15 mesoporous silica for the rst time in 1998. 13,[15][16][17] Well-dened pore size between 4 to 30 nm, thick pore walls, pore architecture, 11,18 wide surface area (up to 1000 m 2 g −1 ), high thermal and hydrothermal stability, and excellent capability to be modied/functionalized are among the features that make materials based on SBA-15 have different applications, including adsorption, drug delivery, imaging, sensor, and catalysis.…”