V13 Poster location 013 Paroxysmal tonic upgaze of infancy: 5 additional cases

Ramelli, Gian Paolo; Taddeo, Ilaria; Herrmann, U.; Weber, Peter

doi:10.1016/s1090-3798(09)70033-9

Cited by 9 publications

(4 citation statements)

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“…Moreover, based on the kind of factories, HMs in the industrial region and those adjacent to it are predicted to be at increased levels. For example, Cd levels in Helena, U.S.A., which happens to contain a smelting company, were found to be 72 mg/kg inside and 1.4 mg/kg between 18 and 60 km away [9,10]. Massive HMs emissions and accumulation have been attributed to agricultural and industrial processes, requiring the international community's specific attention.…”

Section: Introductionmentioning

confidence: 99%

Spatiotemporal Variability Assessment of Trace Metals Based on Subsurface Water Quality Impact Integrated with Artificial Intelligence-Based Modeling

et al. 2022

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Increasing anthropogenic emissions due to rapid industrialization have triggered environmental pollution and pose a threat to the well-being of the ecosystem. In this study, the first scenario involved the spatio-temporal assessment of topsoil contamination with trace metals in the Dammam region, and samples were taken from 2 zones: the industrial (ID), and the agricultural (AG) area. For this purpose, more than 130 spatially distributed samples of topsoil were collected from residential, industrial, and agricultural areas. Inductively coupled plasma—optical emission spectroscopy (ICP-OES)—was used to analyze the samples for various trace metals. The second scenario involved the creation of different artificial intelligence (AI) models, namely an artificial neural network (ANN) and a support vector regression (SVR), for the estimation of zinc (Zn), copper (Cu), chromium (Cr), and lead (Pb) using feature-based input selection. The experimental outcomes depicted that the average concentration levels of HMs were as follows: Chromium (Cr) (31.79 ± 37.9 mg/kg), Copper (Cu) (6.76 ± 12.54 mg/kg), Lead (Pb) (6.34 ± 14.55 mg/kg), and Zinc (Zn) (23.44 ± 84.43 mg/kg). The modelling accuracy, based on different evaluation criteria, showed that agricultural and industrial stations showed performance merit with goodness-of-fit ranges of 51–91% and 80–99%, respectively. This study concludes that AI models could be successfully applied for the rapid estimation of soil trace metals and related decision-making.

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Section: Introductionmentioning

confidence: 99%

Spatiotemporal Variability Assessment of Trace Metals Based on Subsurface Water Quality Impact Integrated with Artificial Intelligence-Based Modeling

et al. 2022

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“…Among theses One important by-product toxicant is Cadmium (Cd), featured by its solubility in water, transferability, persistence and durability, universality, and severe toxicity (Li et al, 2015). Because of these properties, Cd is reported as the sixth most dangerous chemical for living things by the Agency of Toxic substances and Disease Registry (ATSDR) (Li et al, 2018;Ramelli et al, 2009;Zhang et al, 2017). Despite these hazardous features of Cd and warning of ATSDR, the world health organization (WHO) reported that the quantity of Cd is increasing with human activities and accumulate in the air, soil, and water (WHO, 1960;Krzyzanowski and Cohen, 2008;Ramelli et al, 2009;Trejo et al, 2016) resulting in its adsorption by plants, which is diet source for human and animals (Rafati Rahimzadeh et al, 2017;Faroon et al, 2012;Järup and Åkesson, 2009;Ramelli et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

“…Because of these properties, Cd is reported as the sixth most dangerous chemical for living things by the Agency of Toxic substances and Disease Registry (ATSDR) (Li et al, 2018;Ramelli et al, 2009;Zhang et al, 2017). Despite these hazardous features of Cd and warning of ATSDR, the world health organization (WHO) reported that the quantity of Cd is increasing with human activities and accumulate in the air, soil, and water (WHO, 1960;Krzyzanowski and Cohen, 2008;Ramelli et al, 2009;Trejo et al, 2016) resulting in its adsorption by plants, which is diet source for human and animals (Rafati Rahimzadeh et al, 2017;Faroon et al, 2012;Järup and Åkesson, 2009;Ramelli et al, 2009). With respect to food intake, in plant food sources Cd is found in cereals (wheat and rice), root vegetables (potato, celeriac, carrot), and green leafy vegetables, while in animals it is found in cephalopods, crabs, molluscs, crustaceans, and offal products of old animals.…”

Section: Introductionmentioning

confidence: 99%

“…The remaining 2 groups received 10 and 20 mg/kg of ME extract alone respectively using an oral gavage (Figure 1). The exposure of Cd was for 17 days according to ATSDR, Cilenk, and our previous work (Çilenk et al, 2016;Iqbal et al, 2021;Ramelli et al, 2009). On day 18 (roughly 24 hours after last dose administration) the animals were anesthetized and euthanized according to guidelines of Jilin University.…”

Section: Introductionmentioning

confidence: 99%

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Ameliorative effects of morel mushroom (Morchella esculenta) against Cadmium-induced reproductive toxicity in adult male rats

et al. 2022

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Cadmium (Cd) is one of the major toxicants, which affects human health through occupational and environmental exposure. In the current study, we evaluated the protective effects of morel mushrooms against Cd-induced reproductive damages in rats. For this purpose, 30 male rats were divided into 6 groups (n=5/group), the first group served as the control group, second group was treated with an intraperitoneal (i.p) injection of 1 mg/kg/day of Cd. Third and fourth groups were co-treated with 1 mg/kg/day of Cd (i.p) and 10 and 20 mg/kg/day of morel mushroom extract (orally) respectively. The final 2 groups received oral gavage of 10 and 20 mg/kg/day of morel mushroom extract alone. After treatment for 17 days, the animals were euthanized, and testes and epididymis were dissected out. One testis and epididymis of each animal were processed for histology, while the other testis and epididymis were used for daily sperm production (DSP) and comet assay. Our results showed that Cd and morel mushrooms have no effect on animal weight, but Cd significantly decreases the DSP count and damages the heritable DNA which is reversed in co-treatment groups. Similarly, the histopathological results of testes and epididymis show that morel mushrooms control the damage to these tissues. Whereas the morel mushroom extract alone could enhance the production of testosterone. These results conclude that morel mushrooms not only control the damage done by Cd, but it could also be used as a protection mechanism for heritable DNA damage.

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In vitro cadmium exposure induces structural damage and endothelial dysfunction in female rat aorta

Sepulchro Mulher,

Simões,

Rossi

et al. 2023

Biometals

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Cadmium is a heavy metal that is widespread in the environment and has been described as a metalloestrogen and a cardiovascular risk factor. Experimental studies conducted in male animals have shown that cadmium exposure induces vascular dysfunction, which could lead to vasculopathies caused by this metal. However, it is necessary to investigate the vascular effects of cadmium in female rats to understand its potential gender-speci c impact on the cardiovascular system. While its effects on male rats have been studied, cadmium may act differently in females due to its potential as a metalloestrogen. In vitro studies conducted in a controlled environment allow for a direct assessment of cadmium's impact on vascular function, and the use of female rats ensures that gender-speci c effects are evaluated.Therefore, the aim of this study was to investigate the in vitro effects of Cadmium Chloride (ClCd2, 5µM) exposure on vascular reactivity in the isolated aorta of female Wistar rats. Exposure to ClCd2 damaged the architecture of the vascular endothelium. ClCd2 incubation increased the production and release of O2•-, reduced the participation of potassium (K+) channels, and increased the participation of the angiotensin II pathway in response to phenylephrine. Moreover, estrogen receptors alpha (Erα) modulated vascular reactivity to phenylephrine in the presence of cadmium, supporting the hypothesis that cadmium could act as a metalloestrogen. Our results demonstrated that in vitro cadmium exposure induces damage to endothelial architecture and an increase in oxidative stress in the isolated aorta of female rats, which could precipitate vasculopathies. INTRODUCTIONCadmium (Cd) is a non-essential metal that, in its ionic form, is considered a highly toxic element to the environment, as it has high transfer rates to the soil (ATSDR 2012; Satarug 2018). Cd is obtained from geogenic processes and anthropogenic sources, including the burning of fossil fuels, soil contamination from improper disposal of electronic waste, and the use of phosphate fertilizers (Jacobson and Turner 1980;Faroon O, Ashizawa A, Wright S 2012;Sripada and Lager 2022).Population exposure to Cd mainly occurs through soil and food contamination. Vegetables and tobacco leaves accumulate high levels of Cd from the soil, making them sources of contamination through consumption of contaminated food and inhalation of tobacco smoke (Hengstler et al. 2003;Satarug et al. 2003;ATSDR 2012). In fact, smokers have approximately three times the blood concentration of Cd compared to non-smokers (1.58 µg/L for smokers vs. 0.47 µg/L for non-smokers) (Abu-Hayyeh et al. 2001).Cd is an identi ed risk factor for cardiovascular diseases in humans (

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V13 Poster location 013 Paroxysmal tonic upgaze of infancy: 5 additional cases

Cited by 9 publications

References 0 publications

Spatiotemporal Variability Assessment of Trace Metals Based on Subsurface Water Quality Impact Integrated with Artificial Intelligence-Based Modeling

Spatiotemporal Variability Assessment of Trace Metals Based on Subsurface Water Quality Impact Integrated with Artificial Intelligence-Based Modeling

Ameliorative effects of morel mushroom (Morchella esculenta) against Cadmium-induced reproductive toxicity in adult male rats

In vitro cadmium exposure induces structural damage and endothelial dysfunction in female rat aorta

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