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Abstract

Cardiac toxicity associated with oncology drugs, is a known risk, although multiple studies has been performed to detect this problem in an early stage, no definitive results has been achieved. We conducted a clinical study in a large number of patients with a longer follow-up, to evaluate if surveillance tests, such as 2D echocardiogram (ECHO) and radionuclide ventriculography (RNV) can detected early cardiac damage in patients who received anthracycline-based chemotherapy. We conducted a cohort clinical study in 3073 patients with pathological confirmed of diffuse large B-cell lymphoma who had a complete response with a longer follow-up: 18. (range 6.8 to 32.3) years: the mentioned test was performed periodically: every 6 months the first 5 years, an annually from 5 years until relapse, death from any cause or last of follow-up, or the presence of congestive heart failure. Asymptomatic abnormalities in surveillance studies, without clinical and radiological evidence of cardiac damage were observed in 58 cases (1.21%); none of these patients developed clinical evidence of cardiac damage; and eight patients developed clinical and radiology evident changes of heart failure, neither of they showed previous abnormalities in surveillance studies. Multivariate analysis did no show any statistically difference, even in patients whose received > 450 mg/m2. The use of surveillance studies did not predict early cardiac damage and will not be used as surveillance tests. Now resources will be developed, because the risk of cardiac damage secondary to anthracyclines remains constant.