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Flisyuk, E. V.; Shigarova, L. V.

doi:10.1023/a:1024089711621

Cited by 3 publications

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“…Given that the formation of defects on tablet surfaces occurs mainly at the beginning of the process, most frequently because of collisions between pairs of tablets, a probabilistic mathematical model was developed [8] and an equation giving the proportion of damaged tablets Z was derived:…”

Section: Resultsmentioning

confidence: 99%

Studies of the process of tablet coating

Flisyuk

2010

Pharm Chem J

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The application of coatings to tablets is considiered as a complex process with a number of side effects. We present here the results of theoretical and experimental studies of the application of film coatings to tablets in fluidized bed and drum coater devices. Identification of the optimum conditions for applying the correct quantity of coating to tablets should take account of all effects accompanying this process.

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Section: Resultsmentioning

confidence: 99%

Studies of the process of tablet coating

Flisyuk

2010

Pharm Chem J

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“…The wet granulation in fluidized bed is a multistage technology involving an interplay of mutually related processes including the formation of coarse particles upon treatment of the initial mass with a wetting agent, followed by the breakage, abrasion, and drying of granules [1]. The fractional (granulometric) composition and the quality of granules depend on many factors, the most important being the apparatus design, the rate of fluidizing agent (air) supply, the fluidized bed temperature, and the wetting agent type and supply rate.…”

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Modeling the Process of Abrasion of Granules Based on Herbal Extracts in Fluidized Bed

et al. 2005

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The abrasion of granules based on herbal extracts processed in fluidized bed is theoretically analyzed. Formulas for determining the average particle size and the dispersion of the size distribution function are obtained. The influence of the main parameters of the abrasion process on the granulometric composition has been experimentally studied. The coefficient of abrasion intensity is determined.According to this expression, N (t ) = N 0 that implies that the number of granules remains unchanged, where 392 0091-150X/05/3907-0392

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“…However, high-intensity hydrodynamic regime in the fluidized bed was shown [10] to account for defect formation on the surface of tablets as a result of their mutual collisions, which leads to a decrease in the final product quality. It should be noted that the cleavage of tablets is virtually absent in apparatuses of the drum coater type featuring a mild regime of stirring.…”

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A comparative analysis of equipment for coating tablets

Flisyuk

2004

Pharm Chem J

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The process of coating tablets is the final stage in the technology of many drugs. Therefore, the organization of this stage significantly influences the final product quality and yield. By the quality of coating is implied not only the uniformity of the shell thickness on each tablet, but the uniform distribution of the coating material over all tablets in a given batch as well. The latter characteristic is also very important from the standpoint of pharmacokinetics, since it determines the tablet disintegration and dissolution time.The coating of tablets fabricated on modern technological lines is performed in fluidized bed reactors or drum coaters. The fluidized bed apparatuses can be further classified with respect to the hydrodynamic regime (boiling, pulsed, or up-flow bed), the method of gas supply to the fluidized bed, the nozzle shape (cylindrical, cone, cone-cylinder, rectangular), the gas-distribution system design (trough, troughless), and the site of sprayer arrangement (bottom, side, top).In order to ensure hydrodynamic stability of the fluidized bed and provide for good mixing of tablets under the conditions of intense spraying with a coating solution, it is common practice to select apparatuses operating in an active hydrodynamic regime [1]. Brittle tablets are usually coated in apparatuses operating in a softer fluidized bed regime, which increases the coating quality at the expense of decreasing the energy of collisions between tablets [2]. Fluidized bed reactors are characterized by high values of the heat transfer factor and thermal conductivity, instantaneous temperature leveling, and homogeneous solution concentration in the bed.On the other hand, highly disordered motion of the solid phase particles in fluidized bed reactors hinders obtaining tablets with highly uniform shells [3]. For this reason, considerable effort was devoted to modification of such apparatuses, mostly by introducing special gas-distribution devices or spacers, so as to introduce a certain order in the chaotic motion of tablets in the fluidized bed. In such modified reactors, tablets move over certain contours, which provides for a more homogeneous coating. A detailed analysis of these technical solutions was given in [2].A highly promising method of coating tablets is based on the use of coaters, comprising pelletizers with a perforated drum for heat exchanger supply, which find increasing application in the pharmaceutical industry. Such equipment is now available from many European manufacturers such as Manesty, Pharma, Ohara, NR, and Driam [4]. A special feature in the coater design is a rotating perforated drum in which the uncoated cores are charged. When the drum rotates at a moderate speed (25 -30 rpm), the tablets or granules move at relatively low velocity under conditions of optimum mixing of all charged material. This provides high-quality coating at a minimum cleavage and surface damage of tablets. An obvious advantage of drum coaters is the possibility to apply coating on most diverse ready-to-use medicinal ...

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Cited by 3 publications

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Studies of the process of tablet coating

Studies of the process of tablet coating

Modeling the Process of Abrasion of Granules Based on Herbal Extracts in Fluidized Bed

A comparative analysis of equipment for coating tablets

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