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Первушкин, С. В.; Воронин, А. В.; Куркин, В. А.; Sokhina, A. A.; Шаталаев, И. Ф.

doi:10.1023/a:1014435813520

Chemistry of Natural Compounds

2001

DOI: 10.1023/a:1014435813520

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С. В. Первушкин

А. В. Воронин

В. А. Куркин

et al.

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Cited by 3 publications

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“…Sokhina et al [19,20] reported on a spectrophotometric determination of the total content of alkaloids in an aqueous ethanol tincture of greater celandine with preliminary purification on a column with aluminum oxide. According to this technique, the optical density is measured at 366 nm [19] and 420 nm [20] and the results are recalculated for coptisine. Oganesyan et al [21] performed the measurements at 265 nm in 0.1 M hydrochloric acid and recalculated the results with respect to sanguirythrine.…”

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New methods for the quality control of a homeopathic matrix tincture of greater celandine

et al. 2005

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Homeopathic matrix tinctures of greater celandine (Chelidonium majus L.) were obtained using freshly collected and dried plant material (roots). The samples analyzed by GC -MS showed the presence of a combination of alkaloids including canadine, stylopine, homochelidonine, protopine, dihydronitidine, norchelerythrine, dihydroberberine, and norsanguinarine. Some of these compounds (dihydroberberine, norchelerythrine, and norsanguinarine) were present only in the tinctures prepared from dried material and not detected in the preparations obtained using freshly collected raw material. New methods for the quality control of homeopathic matrix tinctures of celandine root have been developed using qualitative chemical reactions and TLC on Sorbfil plates eluted in an ethyl acetate -ethanol -0.1 M sodium hydroxide (6 : 3 : 2) solution with reference to the standard solutions of sanguirythrine (sanguinarine + chelerythrine) and berberine in ethanol. The spots (adsorption bands) on the TLC plates are detected using a modified Dragendorff's reagent. Alkaloids are extracted from tinctures with chloroform. Quantitative estimation of the total alkaloid content (recalculated for sanguirythrine) was carried out by UV spectrophotometry at 278 nm. The total alkaloid content in homeopathic matrix tinctures obtained from freshly collected raw material varies within 0.015 -0.032%, and in that from dried material, within 0.028 -0.081%. 6030091-150X/05/3911-0603

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confidence: 99%

New methods for the quality control of a homeopathic matrix tincture of greater celandine

et al. 2005

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Edible Cyanobacterial Genus Arthrospira: Actual State of the Art in Cultivation Methods, Genetics, and Application in Medicine

et al. 2017

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The cyanobacterial genus Arthrospira appears very conserved and has been divided into five main genetic clusters on the basis of molecular taxonomy markers. Genetic studies of seven Arthrospira strains, including genome sequencing, have enabled a better understanding of those photosynthetic prokaryotes. Even though genetic manipulations have not yet been performed with success, many genomic and proteomic features such as stress adaptation, nitrogen fixation, or biofuel production have been characterized. Many of above-mentioned studies aimed to optimize the cultivation conditions. Factors like the light intensity and quality, the nitrogen source, or different modes of growth (auto-, hetero-, or mixotrophic) have been studied in detail. The scaling-up of the biomass production using photobioreactors, either closed or open, was also investigated to increase the production of useful compounds. The richness of nutrients contained in the genus Arthrospira can be used for promising applications in the biomedical domain. Ingredients such as the calcium spirulan, immulina, C-phycocyanin, and γ-linolenic acid (GLA) show a strong biological activity. Recently, its use in the fight against cancer cells was documented in many publications. The health-promoting action of “Spirulina” has been demonstrated in the case of cardiovascular diseases and age-related conditions. Some compounds also have potent immunomodulatory properties, promoting the growth of beneficial gut microflora, acting as antimicrobial and antiviral. Products derived from Arthrospira were shown to successfully replace biomaterial scaffolds in regenerative medicine. Supplementation with the cyanobacterium also improves the health of livestock and quality of the products of animal origin. They were also used in cosmetic preparations.

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Therapeutical and Nutraceutical Roles of Cyanobacterial Tetrapyrrole Chromophore: Recent Advances and Future Implications

2022

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Cyanobacteria have attracted the attention of researchers because of their promising role as primary and secondary metabolites in functional food and drug design. Due to an ever-increasing awareness of health and the use of natural products to avoid the onset of many chronic and lifestyle metabolic diseases, the global demand for the use of natural drugs and food additives has increased in the last few decades. There are several reports about the highly valuable cyanobacterial products such as carotenoids, vitamins, minerals, polysaccharides, and phycobiliproteins showing antioxidant, anti-cancerous, anti-inflammatory, hypoglycemic, and antimicrobial properties. Recently, it has been shown that allophycocyanin increases longevity and reduces the paralysis effect at least in Caenorhabditis elegans. Additionally, other pigments such as phycoerythrin and phycocyanin show antioxidative properties. Because of their high solubility in water and zero side effects, some of the cyanobacterial tetrapyrrole derivatives, i.e., pigments, facilitate an innovative and alternative way for the beverage and food industries in place of synthetic coloring agents at the commercial level. Thus, not only are the tetrapyrrole derivatives essential constituents for the synthesis of most of the basic physiological biomolecules, such as hemoglobin, chlorophyll, and cobalamin, but also have the potential to be used for the synthesis of synthetic compounds used in the pharmaceutical and nutraceutical industries. In the present review, we focused on the different aspects of tetrapyrrole rings in the drug design and food industries and addressed its remaining limitations to be used as natural nutrient supplements and therapeutic agents.

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Cited by 3 publications

References 2 publications

New methods for the quality control of a homeopathic matrix tincture of greater celandine

New methods for the quality control of a homeopathic matrix tincture of greater celandine

Edible Cyanobacterial Genus Arthrospira: Actual State of the Art in Cultivation Methods, Genetics, and Application in Medicine

Therapeutical and Nutraceutical Roles of Cyanobacterial Tetrapyrrole Chromophore: Recent Advances and Future Implications

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