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Abstract

Sodium molybdate was administered orally to adult male rat at dose level of 10, 30, and 50 mg kg body weight (5 days per week) for 60 days. At higher dose levels significant decrease in absolute and organ-to-body weight ratios of testes, epididymides, seminal vesicles and ventral prostate was observed. The sperm abnormality, associated with decrease in sperm motility and sperm count was also observed. Significant alterations in the activities of marker testicular enzymes, viz. sorbitol dehydrogenase (decreases), lactate dehydrogenase (increases) and gamma-glutamyl transpeptidase (increases) associated with histopathological changes in testes was also observed. Accumulation of molybdenum in testes, epididymides and seminal vesicles was also observed. The study reveals that the oral ingestion of molybdenum may affect the histoarchitecture of testes and sperm morphology. The testicular and spermatotoxic changes may be responsible for observed male mediated developmental toxic effects.

Biomarkers of exposure to molybdenum and other metals in relation to testosterone among men from the United States National Health and Nutrition Examination Survey 2011–2012

“…Acute human Mo poisoning has also been documented in a male in his late-30s who experienced low testosterone, low libido, and psychosis among other health ailments following excessive consumption of Mo dietary supplements for an 18-day period (cumulative dose=13.5 mg, equivalent to 300-800 μg/day) (37). The evidence in humans is supported by several animal studies describing reduced testosterone, lack of libido, seminiferous tubule degeneration, reduced semen volume and sperm concentration, and poor sperm motility and morphology following the oral administration of Mo (38-43). The biological mechanism explaining the inverse association between Mo and testosterone in humans remains unclear.…”

Cadmium, Lead, and Other Metals in Relation to Semen Quality: Human Evidence for Molybdenum as a Male Reproductive Toxicant

“…Human exposure may be elevated in areas involved in the mining of Mo ore, or can also result from certain industrial operations (CDC 2005). Mo is used in the manufacture of electronic parts, glass, ceramics, and lubricants; in the production of catalysts and pigments; in steel alloys; and in chemical reagents found in hospital laboratories (CDC 2005; Pandey and Singh 2002). …”

“…In a recent study of catfish from polluted waters in the Vietnamese Mekong Delta area, Yamaguchi et al (2007) found significant inverse associations between tissue Mo, Pb, and As concentrations and gonadosomatic index (gonad weight/body weight × 100). Pandey and Singh (2002) reported a degeneration of testicular morphology and function and dose-dependent declines in sperm concentration, motility, and normal morphology in a study of rats after oral administration of sodium molybdate. The authors also reported evidence of male-mediated embryotoxicity (e.g., reduced implantation, increased pre- and postimplantation losses, and reduced fetal growth) associated with sodium molybdate exposure.…”

Uranium and Associated Heavy Metals in Ovis aries in a Mining Impacted Area in Northwestern New Mexico

“…Cadmium (Cd) can accumulate in organs and impair renal function [ 10 ]; Lead (Pb) is associated with adverse effects on the nervous, developmental, renal and reproductive systems [ 11 ]. Selenium (Se) toxicosis can cause neurological and gastrointestinal problems [ 12 ] and endocrine function disruption [ 13 ] and is a teratogen in several species of animals [ 14 ]; Molybdenum (Mo) has been shown to be a male reproductive toxicant in animals and humans [ 15 , 16 , 17 ].…”