Untitled

Abstract

The main cause of increasing of infectious diseases cases is due to multidrugresistant microorganisms emergence, particularly Pseudomonas aeruginosa and Staphylococcus aureus, responsible for most of hospital-acquired infections and millions deaths related. Despite development of new antibiotics, control of these microorganisms is not always successful. Several plant extracts have demonstrated antimicrobial effects and may be used as an alternative therapy for these infections. Aiming to evaluate antibacterial activity of extracts from Eleutherine plicata (marupazinho), Geissospermum vellosii (pau-pereira) and Portulaca pilosa (amor crescido) against multidrugresistant bacteria, samples of Oxacillin-Resistant Staphylococcus aureus (ORSA) and multidrug-resistant P. aeruginosa (MDR P. aeruginosa) isolated from human clinical processes were tested. The antibacterial activity was determined by disk diffusion method and minimum inhibitory concentration (MIC) by microdilution method. Extracts and fractions were tested at concentrations of 500, 250, 125, 62.5, 31.2 and 16.2 µg/mL dissolved in DMSO 10%. E.