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Ulubay, Gaye; Kırnap, Mahir; Dedekarginoglu, Balam Er; Küpeli̇, Eli̇f; Eyüboğlu, Füsun Öner; Haberal, Mehmet

doi:10.6002/ect.tdtd2015.p64

Cited by 2 publications

(4 citation statements)

References 24 publications

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Section: Discussionmentioning

confidence: 99%

“…Pulmonary complications following OLT are frequent and are associated with increased morbidity and mortality ( 4 – 6 , 8 , 11 ). While preoperative and early postoperative pleural effusions represent well-described and frequent complications of end-stage liver disease, published evidence about the clinical relevance and outcomes in patients with persistent pleural effusions after an OLT is scant ( 7 , 8 , 12 , 16 , 17 , 20 ). In this retrospective analysis, we investigated the clinical relevance of persistent pleural effusions with a specific focus on the risk factors for and complications related to TL, which we found is a common complication of persistent postoperative pleural effusions.…”

Section: Discussionmentioning

confidence: 99%

“…Prior work suggests that most pleural effusions following liver transplantation resolve within 1–3 months ( 8 , 20 ), but the significance of the remaining persistent effusions is less clear. Further, effusions complicated by TL may portend a different prognosis in comparison to those without TL.…”

Section: Discussionmentioning

confidence: 99%

“…Pulmonary complications after OLT remain common and are associated with increased morbidity and mortality ( 4 – 8 ). Postoperative pleural effusions are among the most frequently recognized pulmonary complications of OLT, occurring in 39–95% of all patients ( 4 , 6 , 9 – 10 ).…”

Section: Introductionmentioning

confidence: 99%

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Postoperative Trapped Lung After Orthotopic Liver Transplantation is a Predictor of Increased Mortality

Cuk¹,

Melamed

Vangala

et al. 2022

Transpl Int

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Pleural effusions are a common complication of orthotopic liver transplantation (OLT), and chronic post-OLT pleural effusions have been associated with worse outcomes. Furthermore, “trapped lung” (TL), defined as a restrictive fibrous visceral pleural peel preventing lung re-expansion, may have prognostic significance. We performed a retrospective analysis of adult OLT recipients over a 9-year period at UCLA Medical Center. Post-OLT patients with persistent pleural effusions, defined by the presence of pleural fluid requiring drainage one to 12 months after OLT, were included for analysis. Outcomes for patients with and without TL were compared using univariate and multivariate analysis. Of the 1722 patients who underwent OLT, 117 (7%) patients met our criteria for persistent postoperative pleural effusion, and the incidence of TL was 21.4% (25/117). Compared to patients without TL, those with TL required more surgical pleural procedures (OR 59.8, 95%CI 19.7–181.4, p < 0.001), spent more days in the hospital (IRR 1.56, 95%CI 1.09–2.23, p = 0.015), and had a higher risk of mortality (HR 2.47, 95%CI 1.59–3.82, p < 0.001) following transplant. In sum, we found that post-OLT TL was associated with higher morbidity, mortality, and healthcare utilization. Future prospective investigation is warranted to further clarify the risk factors for developing postoperative pleural effusions and TL.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Postoperative Trapped Lung After Orthotopic Liver Transplantation is a Predictor of Increased Mortality

Cuk¹,

Melamed

Vangala

et al. 2022

Transpl Int

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Neutrophil extracellular traps predict postoperative pulmonary complications in paediatric patients undergoing parental liver transplantation

et al. 2023

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Background Parental liver transplantation (PLT) improves long-term survival rates in paediatric hepatic failure patients; however, the mechanism of PLT-induced postoperative pulmonary complications (PPCs) is unclear. Methods A total of 133 paediatric patients undergoing PLT were included. Serum levels of NET components, including circulating free DNA (cfDNA), DNA-histone complex, and myeloperoxidase (MPO)-DNA complex, were detected. The occurrence of PPCs post-PLT, prolonged intensive care unit (ICU) stay and death within one year were recorded as the primary and secondary outcomes. Results The overall rate of PPCs in the hospital was 47.4%. High levels of serum cfDNA, DNA-histone complexes and MPO-DNA complexes were associated with an increased risk of PPCs (for cfDNA, OR 2.24; for DNA-histone complex, OR 1.64; and for MPO-DNA, OR 1.94), prolonged ICU stay (OR 1.98, 4.26 and 3.69, respectively), and death within one year (OR 1.53, 2.65 and 1.85, respectively). The area under the curve of NET components for the prediction of PPCs was 0.843 for cfDNA, 0.813 for DNA-histone complexes, and 0.906 for MPO-DNA complexes. During the one-year follow-up, the death rate was higher in patients with PPCs than in patients without PPCs (14.3% vs. 2.9%, P = 0.001). Conclusions High serum levels of NET components are associated with an increased incidence of PPCs and death within one year in paediatric patients undergoing PLT. Serum levels of NET components serve as a biomarker for post-PLT PPCs and a prognostic indicator.

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Abstract: Objectives: Cardiovascular and respiratory system complications are the most common causes of early mortality after liver transplant. We evaluated the causes of respiratory failure as an early postoperative pulmonary complication in liver transplant recipients.

Cited by 2 publications

References 24 publications

Postoperative Trapped Lung After Orthotopic Liver Transplantation is a Predictor of Increased Mortality

Postoperative Trapped Lung After Orthotopic Liver Transplantation is a Predictor of Increased Mortality

Neutrophil extracellular traps predict postoperative pulmonary complications in paediatric patients undergoing parental liver transplantation

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