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Abstract

The present review explains reasons of arthritis a disease related to chronic joint pain and inflammation. It also emphasizes the use of bioactive principles of plant origin to be used to relieve from arthritic pain, aching, stiffness, and swelling. These plant natural products can finish rheumatic pain if they are used regularly according to physician' advice. There are so many active crude extracts and pure compounds which show anti-arthritic activity in Freund's complete adjuvant induced animal models. Certain Ayurvedic formulations also assist to relieve from rheumatic arthritic pain and tone up immune system to function normally. This article shows an overview of medicinal suggestions on the basis of experimental advances made in the herbal medicinal researches in recent years for the treatment of arthritis. There are various dietary supplements which could also provide for management of severe pain of joints, and mitigation of inflammation. It is also suggested that early diagnosis, proper treatment, and healthy dietary habits can reduce the disease spectrum and chronic inflammatory pain.

Identification of the active compounds and their mechanisms of medicinal and edible Heigen based on UHPLC-Q-Exactive Orbitrap MS and network pharmacology

“…According to the active ingredient target network diagram, dibutyl phthalate, 9,10-dihydroxy-12Z-octadecenoic acid, Isochlorogenic acid B, Isochlorogenic acid C, Umbelliferone, 1,3-Dicaffeoylquinic acid, 4-Feruloylquinic acid, Caffeic acid, 3-Feruloylquinic acid, 5-Feruloylquinic acid showed as the most potent active components of Heigen. There is accumulating evidence that ICGA exerts several biological activities, such as antioxidant, and anti-inflammatory (Upadhyay, 2016). Previous studies have shown that caffeic acid can induce cell apoptosis in RA-FLS and reduce productions of IL-6 and TNF-α in FLS (Wang et al, 2017), and it as caspase inhibitors have been regarded as an effective strategy for attenuation of cartilage erosion (Fikry et al, 2019).…”