Vaccaria n-Butanol Extract Lower the Production of Proinflammatory Cytokines and the Infection Risk of T. spiralis In Vivo

Xu, Fei; Hou, Bao; Zhu, Xiaofang; Liu, Yixiao; Shi, Xuelin; Li, Shuangshuang; Li, Zhongjie; Cai, Weiwei; Zhou, Yuetao; Qiu, Ling

doi:10.2478/s11686-019-00064-6

Cited by 10 publications

(6 citation statements)

References 37 publications

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“…Erysodine or erysovine showed an enhanced activity when combined with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in Jurkat cells [ 112 ] but its mechanism of action has not yet been elucidated. Glucoerysodine exerts antiplasmodial effects [ 113 ] while hypaphorin exerts anti-inflammatory [ 114 , 115 ], anti-osteoclastogenic [ 116 ], anti-obesity and anti-diabetic effects [ 117 ], but their potential activities towards cancer cell lines have not been investigated to date.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review of Potential Anticancerous Activities of Erythrina senegalensis DC (Fabaceae)

Fofana

Ouédraogo

Esposito

et al. 2021

Plants

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The objective of this study was to carry out a systematic review of the substances isolated from the African medicinal plant Erythrina senegalensis, focusing on compounds harboring activities against cancer models detailed in depth herein at both in vitro and in vivo preclinical levels. The review was conducted through Pubmed and Google Scholar. Nineteen out of the forty-two secondary metabolites isolated to date from E. senegalensis displayed interesting in vitro and/or in vivo antitumor activities. They belonged to alkaloid (Erysodine), triterpenes (Erythrodiol, maniladiol, oleanolic acid), prenylated isoflavonoids (senegalensin, erysenegalensein E, erysenegalensein M, alpinumisoflavone, derrone, warangalone), flavonoids (erythrisenegalone, senegalensein, lupinifolin, carpachromene) and pterocarpans (erybraedine A, erybraedine C, phaseollin). Among the isoflavonoids called “erysenegalensein”, only erysenealenseins E and M have been tested for their anticancerous properties and turned out to be cytotoxic. Although the stem bark is the most frequently used part of the plant, all pterocarpans were isolated from roots and all alkaloids from seeds. The mechanisms of action of its metabolites include apoptosis, pyroptosis, autophagy and mitophagy via the modulation of cytoplasmic proteins, miRNA and enzymes involved in critical pathways deregulated in cancer. Alpinumisoflavone and oleanolic acid were studied in a broad spectrum of cancer models both in vitro and in preclinical models in vivo with promising results. Other metabolites, including carpachromen, phaseollin, erybraedin A, erysenegalensein M and maniladiol need to be further investigated, as they display potent in vitro effects.

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Section: Discussionmentioning

confidence: 99%

Systematic Review of Potential Anticancerous Activities of Erythrina senegalensis DC (Fabaceae)

Fofana

Ouédraogo

Esposito

et al. 2021

Plants

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“…Trichinellosis is a worldwide severe zoonotic disease that involves the activation of in ammatory cells. It is also accompanied by prominent expression of proin ammatory cytokines in the affected host (Xu et al 2019). Many experts are calling for the use of natural remedies, since most synthetic products have harmful effects and some of them have been found to be cancerous.…”

Section: Discussionmentioning

confidence: 99%

The Curative Effect of Zingiber Officinale and Cinnamomum Zeylanicum Extracts on Experimental Trichinella Spiralis Infection

Mostafa

Fathy

Moawad

et al. 2021

Preprint

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Trichinellosis is a re-emerging zoonotic disease that has become a public health concern since its reported human outbreaks in many countries. The traditional therapy has many adverse effects in addition to the developing resistance. So, this necessitates finding effective natural alternatives. The current study targeted to assess the potential therapeutic effects of Zingiber officinale and Cinnamomum zeylanicum in comparison to albendazole, a conventional therapy for treatment of trichinosis. Sixty mice were classified into five groups (12 mice each), non-infected control, infected control, combined albendazole and prednisolone, Zingiber officinale, and Cinnamomum zeylanicum treated groups. Mice sacrifice was performed on the 7th and 35th days post infection for intestinal and muscular phases respectively. Efficiency of the used preparations was assessed by parasitological, histopathological, immunohistochemical, biochemical studies in addition to ultrastructural evaluation using transmission electron microscopy. A significant reduction in the mean number of T. spiralis adults and larvae was observed in Zingiber officinale and Cinnamomum zeylanicum treated groups, (64.5%, 50.8%) and (68%, 54.6%) respectively. Also, both extracts showed moderate cytoplasmic reactivity for TGF-β1, (69.3% & 67.8%) respectively. The highest reduction in serum TNF- α level was observed in Zingiber officinale treated group during the muscle phase (58.4%) while in the intestinal phase was 50%. The ultrastructural study revealed degenerative effects on both adults and larvae in addition to obvious improvement of the histopathological changes in the small intestine and muscles. We concluded that these herbal extracts especially Zingiber officinale can be considered a practical and successful alternative for the treatment of trichinellosis.

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“…Eighty adult albino rats of both sexes were divided into four experimental groups, 20 rats/each) and each group subdivided into (10 males and 10 females). The first group; (control group), the second group; (T. spiralis) (TR) group, each animal was orally infested with 300 T. spiralis larvae [45][46][47][48]. The third group; (AR+TR) group, each animal in this group was orally infested with 300 T. spiralis larvae followed by treatment with AR at dose of (400 mg / kg body weight) [42][43][44] one day PI for three successive days and other three successive doses on days 21, 22 and 23 PI.…”

Section: Experimental Designmentioning

confidence: 99%

Histopathological study on the effect of Artemisinin multiple doses on the pathogenesis and immune reaction of Trichinella spiralis in albino rats

Dwidar

Mahgoub

Ibrahim

et al. 2022

Mansoura Veterinary Medical Journal

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Vaccaria n-Butanol Extract Lower the Production of Proinflammatory Cytokines and the Infection Risk of T. spiralis In Vivo

Cited by 10 publications

References 37 publications

Systematic Review of Potential Anticancerous Activities of Erythrina senegalensis DC (Fabaceae)

Systematic Review of Potential Anticancerous Activities of Erythrina senegalensis DC (Fabaceae)

The Curative Effect of Zingiber Officinale and Cinnamomum Zeylanicum Extracts on Experimental Trichinella Spiralis Infection

Histopathological study on the effect of Artemisinin multiple doses on the pathogenesis and immune reaction of Trichinella spiralis in albino rats

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