Vaccination against human papillomavirus is not associated with resolution of verruca vulgaris in immunocompetent 9- to 21-year olds

Kost, Yana; Deutsch, Adam; Zhu, Tian Hao; Hulur, Imge; Blasiak, Rachel

doi:10.1016/j.jaad.2021.08.016

Cited by 6 publications

(5 citation statements)

References 6 publications

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“…The study conducted by Kost et al revealed a comparable lack of efficacy in both the qHPV and the 9vHPV vaccine. In all groups, comprising individuals vaccinated postdiagnosis of verruca vulgaris, those vaccinated prior to the diagnosis, and those unvaccinated, there was no discernible elevation in verruca vulgaris resolution rates (54.17% vs. 52.67% vs. 52.22%, p = 0.907) [ 16 ]. Moreover, upon stratification based on the vaccine type, therapeutic outcomes exhibited no significant variation, except for individuals receiving both vaccine types during the follow-up, wherein a notably lower verruca vulgaris complete resolution rate (25.00%, p = 0.006) was observed [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

Unveiling the Therapeutic Horizon: HPV Vaccines and Their Impact on Cutaneous Diseases—A Comprehensive Review

Șandru,

Radu,

Petca

et al. 2024

Vaccines

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Human papillomavirus (HPV) encompasses a diverse array of viruses, comprising approximately 200 serotypes that affect humans. While the majority of HPV strains are associated with benign skin or mucous membrane growths, a subset is implicated in severe health conditions, such as cervical, anal, vulvar, and vaginal cancers. Despite the established effectiveness of HPV vaccines in preventing cervical and anal carcinomas in particular, their therapeutic potential in addressing cutaneous diseases linked to diverse HPV strains remains an intriguing area of investigation. This narrative review critically examines the existing literature to assess the viability of HPV immunization as a therapeutic intervention for prevalent cutaneous conditions. These include genital and extragenital cutaneous warts, epidermodysplasia verruciformis, and keratinocyte carcinomas. The findings suggest a promising dual role for HPV vaccines in preventing and treating dermatologic conditions while emphasizing future research directions, including the immunization perspective against β-HPVs. Moreover, the presence of conflicting study outcomes underscores the imperative for larger-scale, randomized trials with well-matched control groups to validate the efficacy of HPV immunization in the dermatologic context. This review contributes valuable insights into the evolving landscape of HPV-vaccine applications in the field of dermatology.

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Section: Resultsmentioning

confidence: 99%

Unveiling the Therapeutic Horizon: HPV Vaccines and Their Impact on Cutaneous Diseases—A Comprehensive Review

Șandru,

Radu,

Petca

et al. 2024

Vaccines

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show abstract

“…Moreover, treatment and recurrence place a psychological burden on the patient (Huang et al, 2020). Therefore, clarifying the mechanism and effects of HPV infection is essential (Kost et al, 2022). RNA-seq is a powerful tool for broadly profiling gene expression by applying nextgeneration sequencing to quantify mRNA in a tissue sample at a given moment.…”

Section: Discussionmentioning

confidence: 99%

Analysis of differentially expressed genes in Verruca vulgaris <i>vs</i>. adjacent normal skin by RNA-sequencing

GUO,

QI,

LIANG

et al. 2023

BIOCELL

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Introduction: Verruca vulgaris is one of the most common low-risk HPV infections and is characterized by excessive proliferation of keratinocytes. Currently, very little genetic information is available regarding verruca vulgaris in the Chinese population. This study aimed to obtain comprehensive transcript information of verruca vulgaris by RNA sequencing. Methods: High-throughput sequencing was performed on three fresh verruca vulgaris samples and adjacent normal skin on the Illumina sequencing platform. The transcriptomes were analyzed using bioinformatics and the differentially expressed genes (DEGs) were verified by immunohistochemistry. Verruca vulgaris exhibited a unique molecular signature. Results: In total, 1,643 DEGs were identified in verruca vulgaris compared to normal skin. The functions of the DEGs were studies by Gene Ontology (GO) enrichment, Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, DEGs Reactome analysis, disease annotation function, and STRING protein-protein interaction (PPI) network analysis. The results revealed 595 GO terms associated with the cell cycle, signal transduction, immune system, signaling molecules, and interaction. The Reactome analysis revealed enrichment in reversible hydration of carbon dioxide and BMP signaling, while the disease annotation function revealed that the enriched DEGs are involved in keratosis disorders. The STRING PPI network showed that the edges with the highest density mainly included the 2′-5′ oligoadenylate synthase (OAS) family-related proteins. Furthermore, the M-code analysis found ISG15, IRF7, and OASL were scored as significant modules and their high expression compared to the control was verified by immunohistochemistry. Conclusion:These findings contribute to the genetic information of verruca vulgaris in the Chinese population, revealing that interferon-stimulated genes may play essential roles in verruca vulgaris.

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“…This was highlighted by a recent case series that found no significant increase in wart clearance after vaccination. 10 There is a need for randomized placebo-controlled trials before broad recommendations can be made, but it may still be prudent to offer this relatively low-side-effect option to patients preparing for organ transplantation.…”

Section: Discussionmentioning

confidence: 99%

Systemic 9-valent human papillomavirus vaccine for recalcitrant common cutaneous warts in preparation for renal transplant

et al. 2022

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Vaccination against human papillomavirus is not associated with resolution of verruca vulgaris in immunocompetent 9- to 21-year olds

Cited by 6 publications

References 6 publications

Unveiling the Therapeutic Horizon: HPV Vaccines and Their Impact on Cutaneous Diseases—A Comprehensive Review

Unveiling the Therapeutic Horizon: HPV Vaccines and Their Impact on Cutaneous Diseases—A Comprehensive Review

Analysis of differentially expressed genes in Verruca vulgaris <i>vs</i>. adjacent normal skin by RNA-sequencing

Systemic 9-valent human papillomavirus vaccine for recalcitrant common cutaneous warts in preparation for renal transplant

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