Vaccination against Koi Herpesvirus Disease

Dishon, Arnon; Ashoulin, Ofer; Weber, E. Scott; Kotler, Moshe

doi:10.1002/9781118806913.ch27

Cited by 3 publications

(10 citation statements)

References 46 publications

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“…Since its emergence in the late 1990s, CyHV-3 has caused mass outbreaks in carp in both natural environments and in fish farms. Initial outbreaks in Israel were responsible for annual losses estimated to US$ 3 million [15]. Similarly, early outbreaks in Indonesia (2002,2003) were held responsible for a global loss of US$ 25 million [15].…”

Section: Epidemiological Status Of Cyhv-3mentioning

confidence: 99%

“…Initial outbreaks in Israel were responsible for annual losses estimated to US$ 3 million [15]. Similarly, early outbreaks in Indonesia (2002,2003) were held responsible for a global loss of US$ 25 million [15]. Once Table 1 CyHV-3 vaccines in use and under development.…”

Section: Epidemiological Status Of Cyhv-3mentioning

confidence: 99%

“…Once Table 1 CyHV-3 vaccines in use and under development. by KoVax Ltd [6,11,15,23,[33][34][35][36][37] CyHV-3 T ΔDUT/TK Recombinant attenuated vaccine Serial passages in cell culture (CyHV-3-T) followed by deletion of the dUTPase and TK ORFs by recombination in eukaryotic cells…”

Section: Epidemiological Status Of Cyhv-3mentioning

confidence: 99%

“…The safety and efficacy profile of this conventional attenuated vaccine was studied extensively [6,11,15,23,[33][34][35][36][37]. Regarding the safety, several independent trials showed residual virulence in some circumstances.…”

Section: Conventional Attenuated Vaccinesmentioning

confidence: 99%

“…Nevertheless, field trials were successfully conducted for regulatory purposes in Israel, Indonesia and USA. They indicated that this attenuated strain met the requirements necessary for registration of the vaccine in these regions [15].…”

Section: Conventional Attenuated Vaccinesmentioning

confidence: 99%

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Current knowledge and future prospects of vaccines against cyprinid herpesvirus 3 (CyHV-3)

Boutier

Gao

Donohoe

et al. 2019

Fish & Shellfish Immunology

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Aquaculture is one of the world's most important and fastest growing food production sectors, with an average annual growth of 5.8% during the period 2001-2016. Common carp (Cyprinus carpio) is one of the main aquatic species produced for human consumption and is the world's third most produced finfish. Koi carp, on the other hand, are grown as a popular ornamental fish. In the late 1990s, both of these sectors were threatened by the emergence of a deadly disease caused by cyprinid herpesvirus 3 (CyHV-3; initially called koi herpesvirus or KHV). Since then, several research groups have focused their work on developing methods to fight this disease. Despite increasing knowledge about the pathobiology of this virus, there are currently no efficient and costeffective therapeutic methods available to fight this disease. Facing the lack of efficient treatments, safe and efficacious prophylactic methods such as the use of vaccines represent the most promising approach to the control of this virus. The common carp production sector is not a heavily industrialized production sector and the fish produced have low individual value. Therefore, development of vaccine methods adapted to mass vaccination are more suitable. Multiple vaccine candidates against CyHV-3 have been developed and studied, including DNA, bacterial vector, inactivated, conventional attenuated and recombinant attenuated vaccines. However, there is currently only one vaccine commercially available in limited regions. The present review aims to summarize and evaluate the knowledge acquired from the study of these vaccines against CyHV-3 and provide discussion on future prospects.

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Section: Epidemiological Status Of Cyhv-3mentioning

confidence: 99%

Section: Epidemiological Status Of Cyhv-3mentioning

confidence: 99%

Section: Epidemiological Status Of Cyhv-3mentioning

confidence: 99%

Section: Conventional Attenuated Vaccinesmentioning

confidence: 99%

Section: Conventional Attenuated Vaccinesmentioning

confidence: 99%

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Current knowledge and future prospects of vaccines against cyprinid herpesvirus 3 (CyHV-3)

Boutier

Gao

Donohoe

et al. 2019

Fish & Shellfish Immunology

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Purification and concentration of infectious koi herpesvirus using steric exclusion chromatography

Eilts,

Jordan,

Harsy

et al. 2023

Journal of Fish Diseases

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Koi herpesvirus (KHV) is the causative agent of a koi herpesvirus disease (KHVD) inducing high mortality rates in common carp and koi (Cyprinus carpio). No widespread effective vaccination strategy has been implemented yet, which is partly due to side effects of the immunized fish. In this study, we present an evaluation of the purification of infectious KHV from host cell protein and DNA, using the steric exclusion chromatography. The method is related to conventional polyethylene glycol (PEG) precipitation implemented in a chromatographic set‐up and has been applied for infectious virus particle purification with high recoveries and impurity removal. Here, we achieved a yield of up to 55% of infectious KHV by using 12% PEG (molecular weight of 6 kDa) at pH 7.0. The recoveries were higher when using chromatographic cellulose membranes with 3–5 μm pores in diameter instead of 1 μm. The losses were assumed to originate from dense KHV precipitates retained on the membranes. Additionally, the use of >0.6 M NaCl was shown to inactivate infectious KHV. In summary, we propose a first step towards a purification procedure for infectious KHV with a possible implementation in fish vaccine manufacturing.

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Maintenance of Fish Health in Aquaculture: Review of Epidemiological Approaches for Prevention and Control of Infectious Disease of Fish

Assefa¹,

Abunna

2018

Veterinary Medicine International

393

232

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Aquaculture is rapidly growing part of agriculture worldwide. It makes up around 44 percent of total fish production globally. This increased growth of production is achieved despite facing many challenges in the aquaculture environment. Among production limiting challenges, the infectious disease takes the lion share by causing multibillion-dollar loss annually. To reduce the impact of the fish disease, it is necessary to address health constraints based on scientifically proven and recommended ways. This review aims at pointing out some of the best approaches to prevention and control of infectious disease in aquaculture. Among the effective prevention and control strategies, vaccination is one of the key practices. Types of vaccines for use in fish include killed vaccines, attenuated vaccines, DNA vaccines, recombinant technology vaccines, and synthetic peptide vaccines. Administration techniques of vaccines in fish include oral, injection, or immersion methods. Antibiotics are also in use in aquaculture despite their side effects in the development of drug resistance by microorganisms. Biological and chemical disease control strategies such as using probiotics, prebiotics, and medicinal plants are widely in use. Biosecurity measures in aquaculture can keep the safety of a facility from certain disease-causing agents that are absent in particular system. Farm-level biosecurity measures include strict quarantine measures, egg disinfection, traffic control, water treatments, clean feed, and disposal of mortalities. In conclusion, rather than trying to treat every disease case, it advisable to follow a preventive approach before the event of any disease outbreaks.

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Vaccination against Koi Herpesvirus Disease

Cited by 3 publications

References 46 publications

Current knowledge and future prospects of vaccines against cyprinid herpesvirus 3 (CyHV-3)

Current knowledge and future prospects of vaccines against cyprinid herpesvirus 3 (CyHV-3)

Purification and concentration of infectious koi herpesvirus using steric exclusion chromatography

Maintenance of Fish Health in Aquaculture: Review of Epidemiological Approaches for Prevention and Control of Infectious Disease of Fish

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