Vaccination Against Measles: Part II. Clinical Trial in Nigerian Children

Symposium on Measles

“…It was clear from these results that despite the good immunological response none of the three batches of vaccine used was suitable for use in England. Similar results were reported from a trial in Nigeria (Collard et al 1961). In view of these findings attempts were made to attenuate the strain by serial passage, and two further batches were tested after further passage.…”

Studies on Measles Vaccination in Nigerian Children

“…In Ibadan the first trials of live measles vaccines were undertaken in 1960. In this study three live attenuated measles vaccines were used, and were found to produce satisfactory antibody responses; but the frequency and severity of the reactions which followed vaccination were such as to preclude their general use (Collard et al, 1961).…”

Simultaneous administration of live measles virus vaccine and smallpox vaccine.

“…Much emphasis has been placed on the use of live vaccines, and there have been numerous reports on the use of the attenuated types of measles vaccines (Collard et al, 1961 ;Hendrickse et al, 1964;Krugman, 1965 ;Smorodintsev et al, 1965 ;Rey et al, 1965b), as well as on the comparison between attenuated and further attenuated vaccine strains with regard to clinical reactions and serological response (Du Pan, 1965 ;Hendrickse et al, 1964Hendrickse et al, , 1965Hendrickse et al, , 1966aHendrickse et al, , 1966b.…”