Vaccination against parasites – status quo and the way forward

Joachim, Anja

doi:10.1186/s40813-016-0047-9

Cited by 10 publications

(5 citation statements)

References 47 publications

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“…In the past decade, significant progress has been made in the development of T. gondii vaccines, new antigens, adjuvants, and immunization strategies. Vaccine candidates range from attenuated vaccines, subunit vaccines, DNAs, RNAs, and exosomes ( 17 , 18 ) The advantages and disadvantages of these vaccines have been studied primarily in mouse models to determine their potential to elicit cellular and humoral immune responses and their protective effects against T. gondii challenge ( 19 – 22 ). The main disadvantage of these vaccine models is that the great majority of them was not able to protect against the virulent challenge ( 23 ).…”

Section: Introductionmentioning

confidence: 99%

GRA24-Based DNA Vaccine Prolongs Survival in Mice Challenged With a Virulent Toxoplasma gondii Strain

et al. 2019

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Toxoplasma gondii causes infections in a wide range of intermediate hosts and remains a threatening disease worldwide because of the lack of effective drugs and vaccines. Dense granule protein 24 (GRA24) is a novel essential virulence factor that is transferred into the nucleus of host cells from the parasitophorous vacuole to regulate gene expression. In the present study, bioinformatic analysis showed that GRA24 had a high score for B-cell and T-cell epitopes compared with surface antigen 1 (SAG1), which has been studied as a promising vaccine candidate. As a DNA vaccine, pVAX1-GRA24 was injected intramuscularly into BALB/c mice and the induced immune response was evaluated. pVAX1-GRA24 induced high levels of a mixed Th1/Th2 cytokines at 6 weeks after immunization. Antibody determinations, cytokines [interferon gamma (IFN-γ), interleukin (IL)-12, IL-4, IL-10], antigen-specific lymphocyte proliferation, CD4+ and CD8+ T lymphocytes, and cytotoxic T lymphocyte activity showed that mice immunized with pVAX1-GRA24 produced specific humoral and cellular immune responses. The expression levels of interferon regulatory factor 8 (IRF8), nuclear factor kappa B (NF-κB), and T-Box 21 (T-bet) were significantly higher in the pVAX1-GRA24 immunization group than in the control groups. Survival times were prolonged significantly (24.6 ± 5.5 days) in the mice immunized with pVAX1-GRA24 compared with the mice in the control groups, which died within 7 days of T. gondii challenge (p < 0.05). The results of the present study showed that pVAX1-GRA24 induced a T. gondii-specific immune response and thus represents a promising candidate vaccine to treat toxoplasmosis.

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Section: Introductionmentioning

confidence: 99%

GRA24-Based DNA Vaccine Prolongs Survival in Mice Challenged With a Virulent Toxoplasma gondii Strain

et al. 2019

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“…Therefore, vaccines would lessen the need for antibiotics to control diseases and offer veterinary practitioners much needed tools (Potter et al, 2008 ; Kolotilin et al, 2014 ). Moreover, the growing public interest in production of chemical-free food, which is fostered by consumer concern about drug residues in meat, eggs or milk supports the importance of the development of new veterinary vaccines (Murphy, 2012 ; Joachim, 2016 ).…”

Section: Veterinary Vaccine Development Against Fbds Caused By Parasimentioning

confidence: 99%

Use of Veterinary Vaccines for Livestock as a Strategy to Control Foodborne Parasitic Diseases

Sander

López

Morales

et al. 2020

Front. Cell. Infect. Microbiol.

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Foodborne diseases (FBDs) are a major concern worldwide since they are associated with high mortality and morbidity in the human population. Among the causative agents of FBDs, Taenia solium, Echinococcus granulosus, Toxoplasma gondii, Cryptosporidium spp., and Trichinella spiralis are listed in the top global risk ranking of foodborne parasites. One common feature between them is that they affect domestic livestock, encompassing an enormous risk to global food production and human health from farm to fork, infecting animals, and people either directly or indirectly. Several approaches have been employed to control FBDs caused by parasites, including veterinary vaccines for livestock. Veterinary vaccines against foodborne parasites not only improve the animal health by controlling animal infections but also contribute to increase public health by controlling an important source of FBDs. In the present review, we discuss the advances in the development of veterinary vaccines for domestic livestock as a strategy to control foodborne parasitic diseases.

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“…For example, vaccines provide long-term protection and eliminate the phenomenon of drug resistance of T. spiralis . Moreover, vaccines improve food safety by reducing drug residues in meat ( Joachim, 2016 ; Sander et al, 2020 ). Studies have found that a window period between T. spiralis infection and anti- Trichinella IgG positivity ( Gamble et al, 2004 ; Cui J. et al, 2015 ; Wang et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Vaccines as a Strategy to Control Trichinellosis

Tang

et al. 2022

Front. Microbiol.

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Trichinellosis caused by Trichinella spiralis is a worldwide food-borne parasitic zoonosis. Several approaches have been performed to control T. spiralis infection, including veterinary vaccines, which contribute to improving animal health and increasing public health by preventing the transmission of trichinellosis from animals to humans. In the past several decades, many vaccine studies have been performed in effort to control T. spiralis infection by reducing the muscle larvae and adult worms burden. Various candidate antigens, selected from excretory-secretory (ES) products and different functional proteins involved in the process of establishing infection have been investigated in rodent or swine models to explore their protective effect against T. spiralis infection. Moreover, different types of vaccines have been developed to improve the protective effect against T. spiralis infection in rodent or swine models, such as live attenuated vaccines, natural antigen vaccines, recombinant protein vaccines, DNA vaccines, and synthesized epitope vaccines. However, few studies of T. spiralis vaccines have been performed in pigs, and future research should focus on exploring the protective effect of different types of vaccines in swine models. Here, we present an overview of the strategies for the development of effective T. spiralis vaccines and summarize the factors of influencing the effectiveness of vaccines. We also discuss several propositions in improving the effectiveness of vaccines and may provide a route map for future T. spiralis vaccines development.

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Vaccination against parasites – status quo and the way forward

Cited by 10 publications

References 47 publications

GRA24-Based DNA Vaccine Prolongs Survival in Mice Challenged With a Virulent Toxoplasma gondii Strain

GRA24-Based DNA Vaccine Prolongs Survival in Mice Challenged With a Virulent Toxoplasma gondii Strain

Use of Veterinary Vaccines for Livestock as a Strategy to Control Foodborne Parasitic Diseases

Vaccines as a Strategy to Control Trichinellosis

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