Vaccination against spontaneous abortion in mice

Chaouat, G.; Kiger, N; Wegmann, T

doi:10.1016/0165-0378(83)90248-6

Cited by 129 publications

(47 citation statements)

References 6 publications

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“…31 Antigen specificity and linked immunoprotection from minor antigens were affirmed after observing that vaccination of CBA ⁄ J females with BALB ⁄ c male antigens before mating with DBA ⁄ 2J reduced abortion rates and generated Treg, which were in turn able to protect from fetal rejection if isolated and transferred into abortion-prone mice. 31,70 The transfer of antigen-specific Treg was able to rescue from fetal rejection by inducing the generation of a transient tolerant milieu at the fetal-maternal interface that was characterized by high levels of TGF-b, HO-1, and Leukemia inhibitory factor (LIF). 69 This introduced the concept of Treg generating a local transient tolerance.…”

Section: Adoptive Transfer Of Treg In the Cba · Dba Abortion-prone Modelmentioning

confidence: 99%

REVIEW ARTICLE: Regulatory T Cells and Their Role in Pregnancy

Leber

Teles

Zenclussen

2010

American J Rep Immunol

148

116

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Citation Leber A, Teles A, Zenclussen AC. Regulatory T cells and their role in pregnancy. Am J Reprod Immunol 2010Regulatory T cells emerge in the last years as key players in allowing fetal survival within the maternal uterus. They were shown to be a unique subpopulation of T cells expanding during human and murine pregnancy. The importance of Treg for a normal pregnancy situation was proven by studies showing that their absence impairs murine pregnancy while the adoptive transfer of Treg prevents fetal rejection. In humans, pregnancy pathologies are associated with lower Treg frequencies while therapies that improve pregnancy outcome are able to boost their number. Functional studies have shown that Treg can regulate immune cell responses directly at the fetal–maternal interface either by interacting with other cells or by inducing the expression of immune regulatory molecules. This article revises relevant literature on regulatory T cells in human and murine pregnancy.

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Section: Adoptive Transfer Of Treg In the Cba · Dba Abortion-prone Modelmentioning

confidence: 99%

REVIEW ARTICLE: Regulatory T Cells and Their Role in Pregnancy

Leber

Teles

Zenclussen

2010

American J Rep Immunol

148

116

View full text Add to dashboard Cite

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“…For many years, the most compelling animal model of immunologically mediated spontaneous fetal loss has been the murine (CBA/JϫDBA/2) mating combination, in which between 20 and 50% of the fetus is resorbed by gestational day 13 (15). The critical importance of this precise parental genetic combination and the ability to suppress fetal loss by preimmunizing females with BALB/c male lymphocytes or by prior mating to a BALB/c male (13,16) point to an immunological component that contributes to this fetal loss syndrome. NK cells and macrophages have been implicated as cellular mediators of the syndrome, and excessive NO and TNF-␣ release by decidual mononuclear cells have been suggested as effector mechanisms that become dysregulated in this strain combination (17,18).…”

mentioning

confidence: 99%

“…In the present study we used a murine abortion-prone model in which CBA/J females impregnated by DBA/2 males have a high incidence of fetal resorptions, whereas a similar (H-2 k ϫH-2 d ) mating, CBA/J females impregnated by BALB/c males, have normal low resorption rates (13,14). For many years, the most compelling animal model of immunologically mediated spontaneous fetal loss has been the murine (CBA/JϫDBA/2) mating combination, in which between 20 and 50% of the fetus is resorbed by gestational day 13 (15).…”

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confidence: 99%

Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Induces Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings

Jin¹,

Li²,

Zhang

et al. 2004

The Journal of Immunology

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The embryo expresses paternal Ags foreign to the mother and therefore has been viewed as an allograft. It has been shown that anergic T cells generated by blocking of the CD28/B7 costimulatory pathway with anti B7-1 and anti B7-2 mAbs can be transferred as suppresser cells to prevent allograft rejection. Little is known, however, about the in vivo function of anti-B7-treated T cells after their transfer into abortion-prone mice in the maintenance of materno-fetal tolerance. In the present study, abortion-prone CBA/J females mated with DBA/2 males were administered anti-B7-1 and anti-B7-2 mAbs on day 4 of gestation (murine implantation window). The anti-B7-treated T cells subsequently were adoptively transferred into abortion-prone CBA/J mice. We demonstrated that costimulation blockade with anti-B7 mAbs at the time of implantation resulted in altered allogeneic T cell response and overcame increased maternal rejection to the fetus in the CBA/J×DBA/2 system. The transferred anti-B7-treated T cells appeared to be regulatory, decreasing responsiveness and generating clonal deviation in maternal recipient T cells. The transferred CFSE-labeled T cells were found to reside in the spleen and uterine draining lymph nodes, and a few were localized to the materno-fetal interface of the maternal recipient. Our findings suggest that the anti-B7-treated T cells not only function as potent suppresser cells, but also exert an immunoregulatory effect on the maternal recipient T cells, which cosuppresses maternal rejection to the fetus. This procedure might be considered potentially useful for fetal survival when used as an immunotherapy for human recurrent spontaneous abortion.

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“…Major progress in our understanding of the role of C in PE has been made using the abortion-prone mating combination CBA/J female 3 DBA/2 male, characterized by high fetal resorption rate and growth restriction (7,8). Girardi and colleagues (9) first reported their finding that the angiogenic factors are dysregulated in CBA/J 3 DBA/2 mating with increased levels of soluble vascularendothelial growth factor receptor and reduced concentration of vascular-endothelial growth factor resulting in defective vascularization and impaired development of the placenta.…”

mentioning

confidence: 99%

Critical Role and Therapeutic Control of the Lectin Pathway of Complement Activation in an Abortion-Prone Mouse Mating

Petitbarat

Durigutto

Macor

et al. 2015

The Journal of Immunology

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The abortion-prone mating combination CBA/J × DBA/2 has been recognized as a model of preeclampsia, and complement activation has been implicated in the high rate of pregnancy loss observed in CBA/J mice. We have analyzed the implantation sites collected from DBA/2-mated CBA/J mice for the deposition of the complement recognition molecules using CBA/J mated with BALB/c mice as a control group. MBL-A was observed in the implantation sites of CBA/J × DBA/2 combination in the absence of MBL-C and was undetectable in BALB/c-mated CBA/J mice. Conversely, C1q was present in both mating combinations. Searching for other complement components localized at the implantation sites of CBA/J × DBA/2, we found C4 and C3, but we failed to reveal C1r. These data suggest that complement is activated through the lectin pathway and proceeds to completion of the activation sequence as revealed by C9 deposition. MBL-A was detected as early as 3.5 d of pregnancy, and MBL-A deficiency prevented pregnancy loss in the abortion-prone mating combination. The contribution of the terminal complex to miscarriage was supported by the finding that pregnancy failure was largely inhibited by the administration of neutralizing Ab to C5. Treatment of DBA/2-mated CBA/J mice with Polyman2 that binds to MBL-A with high affinity proved to be highly effective in controlling the activation of the lectin pathway and in preventing fetal loss.

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Vaccination against spontaneous abortion in mice

Cited by 129 publications

References 6 publications

REVIEW ARTICLE: Regulatory T Cells and Their Role in Pregnancy

REVIEW ARTICLE: Regulatory T Cells and Their Role in Pregnancy

Adoptive Transfer of Paternal Antigen-Hyporesponsive T Cells Induces Maternal Tolerance to the Allogeneic Fetus in Abortion-Prone Matings

Critical Role and Therapeutic Control of the Lectin Pathway of Complement Activation in an Abortion-Prone Mouse Mating

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