Vaccination: An evolutionary engine for pathogens? Conference report

Soubeyrand, B.; Greenberg, Michael; Tibayrenc, Michel; Louis, Jacques; Dutel, Catherine; Simondon, François; Saadatian‐Elahi, Mitra

doi:10.1016/j.meegid.2014.07.007

Cited by 1 publication

(2 citation statements)

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“…The theory is that host immune recognition postvaccination will favor the selection of particular virus lineages. Proportional increase of immune individuals by vaccination enhances such evolutionary selection pressures 26 . Another fundament is that such evolutionary processes depend upon genetic diversity, which is high even for the most oncogenic hrHPVs both at species and strain level 11,19 .…”

Section: Evolutionary Repercussion Of Hpv Vaccination On Defining The...mentioning

confidence: 99%

“…Proportional increase of immune individuals by vaccination enhances such evolutionary selection pressures. 26 Another fundament is that such evolutionary processes depend upon genetic diversity, which is high even for the most oncogenic hrHPVs both at species and strain level. 11 , 19 Therefore, it has been important to systematically examine the available community‐randomized HPV vaccine trial data for possible clearance patterns of vaccine‐targeted HPVs ecological niche 3 and search signs of evolutionary responses of the nonvaccine targeted lower oncogenicity hrHPV types such as type replacement.…”

Section: Evolutionary Repercussion Of Hpv Vaccinat...mentioning

confidence: 99%

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Assessing the risk of cervical neoplasia in the post‐HPV vaccination era

Lehtinen

Pimenoff

Nedjai

et al. 2022

Intl Journal of Cancer

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This review is based on the recent EUROGIN scientific session: “Assessing risk of cervical cancer in the post‐vaccination era,” which addressed the demands of cervical intraepithelial neoplasia (CIN)/squamous intraepithelial lesion (SIL) triage now that the prevalence of vaccine‐targeted oncogenic high‐risk (hr) human papillomaviruses (HPVs) is decreasing. Change in the prevalence distribution of oncogenic HPV types that follows national HPV vaccination programs is setting the stage for loss of positive predictive value of conventional but possibly also new triage modalities. Understanding the contribution of the latter, most notably hypermethylation of cellular and viral genes in a new setting where most oncogenic HPV types are no longer present, requires studies on their performance in vaccinated women with CIN/SIL that are associated with nonvaccine HPV types. Lessons learned from this research may highlight the potential of cervical cells for risk prediction of all women's cancers.

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Section: Evolutionary Repercussion Of Hpv Vaccination On Defining The...mentioning

confidence: 99%