Vaccination-Immunoprophylaxis in Coccidioidomycosis

Stevens, David A.

doi:10.1007/978-1-4757-1712-9_22

Cited by 1 publication

(1 citation statement)

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“…How the host deals with B. dermatitidis is of special interest because in vivo (10) and in vitro (4) studies have suggested that the parasiticphase organism, unlike, for example, Histoplasma capsulatum, is largely extracellular. Of note, resistance to pulmonary coccidioidomycosis has been demonstrated after s.c. presentation of parasitic-phase coccidioidal antigen (17). The development of resistance to a 70% lethal dose i.n.…”

Section: Discussionmentioning

confidence: 99%

Protection against pulmonary blastomycosis: correlation with cellular and humoral immunity in mice after subcutaneous nonlethal infection

Morozumi¹,

Brummer²,

Stevens³

1982

Infect Immun

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A model of pulmonary blastomycosis in the mouse, in which the portal of entry is the same as natural human infection, was used to study resistance to challenge after subcutaneous infection. One week after subcutaneous infection, mice were partially resistant to pulmonary challenge, and mice challenged two weeks after infection were resistant. Measurement of cellular and humoral immune responses to Blastomyces dermatitidis antigens after subcutaneous infection showed the following. (i) Delayed-type hypersensitivity appeared 1 week after infection, and responses increased for 3 weeks thereafter. (ii) Proliferative responses in vitro appeared in spleen cells at 1 week and in contralateral lymph node cells at 3 weeks, (iii) Serum antibody, detected by an enzyme-linked immunosorbent assay, appeared 1 week after infection and then increased in titer. (iv) Peritoneal macrophages were activated to inhibit replication of B. dermatitidis in vitro by the first week after infection. Prior subcutaneous infection also resulted in rapid clearing of a second subcutaneous challenge, as well as resistance to a lethal intraperitoneal challenge. This resistance was associated with the development of cell-mediated and humoral immune responses. These data provide a chronological framework for selective transfer experiments.

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Section: Discussionmentioning

confidence: 99%