Vaccination of adult sheep with reduced doses ofBrucella Melitensis strain rev. 1

Crowther, R.W.; Orphanides, A.; Polydorou, K.

doi:10.1007/bf02236385

Cited by 10 publications

(3 citation statements)

References 3 publications

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“…15,27,28 In comparison to full dose, the reduced dose elicits shorter and less intense antibody response following vaccination [29][30][31] and can be used safely in pregnant sheep and goats. [30][31][32][33][34][35] However, excretion of vaccine strain mainly in vaginal excretion and foetal contents during abortion in pregnant sheep and goats after field infections [36][37][38][39] further showed the necessity to put stress on different methods of vaccination.…”

Section: Discussionmentioning

confidence: 99%

Vaccines for Caprine Brucellosis: Status and Prospective

Kumar¹

2016

IJVV

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Brucellosis is an endemic world wide zoonosis, affecting both human and animals. It is caused by bacteria belonging to genus Brucella. There is host specificity in Brucella species, however selective and restricted inter species transmission is also reported causing zoonosis. In human brucellosis is mainly caused by Brucella melitensis followed by Brucella abortus. Brucella melitensis is more virulent than Brucella abortus and first to cause human brucellosis. It is responsible for caprine brucellosis and goats residing in close vicinity to human are main source of infection. This can be avoided be the use of safe and effective vaccination of goat population. There is an effective vaccine for the caprine vaccination ie. Rev.1, however it has hazardous to human, thus its use is not recommended in many of the countries. Under such circumstances development and trials of various traditional and advanced vaccines have been attempted. These have been summarized and discussed on merit and demerit basis in present paper with a possibility to obtain safe and effective vaccine against Brucella melitensis.

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Section: Discussionmentioning

confidence: 99%

Vaccines for Caprine Brucellosis: Status and Prospective

Kumar¹

2016

IJVV

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“…However, field results obtained after the application of Rev. 1/S19 at reduced doses has led to a divergence of opinions among different experts about its usefulness and implications: many authors have reported a significant number of reproductive failures/vaccine excretion [155][156][157], advising against the use of this strategy in brucellosis control programs. In addition, some authors have showed that this immunization strategy using Rev.…”

Section: Application Of Reduced Doses Of Vaccinementioning

confidence: 99%

“…1/S19 induces an inadequate protection against B. melitensis/B. abortus infection [156][157][158][159]. Additionally, reduced doses may not avoid the induction of persistent antibody titters when Rev.…”

Section: Application Of Reduced Doses Of Vaccinementioning

confidence: 99%

Control of Animal Brucellosis — The Most Effective Tool to Prevent Human Brucellosis

García‐Seco¹,

Domı́nguez²,

Álvarez³

2015

Updates on Brucellosis

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The World Health Organization classifies brucellosis as one of the seven neglected endemic zoonosis which contribute to the perpetuation of poverty in developing countries. Although most of the developed countries are free from this important zoonosis, brucellosis has still a widespread distribution in the Mediterranean region, the Middle East, Central Asia, and parts of Latin America, making it a global problem. Nearly half a million of new cases of human brucellosis are reported each year around the world, in which animals (or products of animal origin) are the most likely source of infection. Brucella melitensis, the main etiologic agent of small ruminant brucellosis, is the most prevalent specie involved in cases of human disease in most parts of the world. Additionally, Brucella abortus (main responsible of bovine brucellosis) and Brucella suis (the most common etiological agent of porcine brucellosis) are often associated with human brucellosis. In animal production, brucellosis has a strong economic impact due not only to its direct consequences (e.g., reproductive failures) but also to indirect loses (e.g., trade restrictions). The problem of brucellosis could be considered a clear example of the need for a "One World, One Health" strategy, given that the only approach to achieve its control and subsequent eradication is the cooperation between public and animal health authorities. The prevention of human brucellosis cannot be achieved without the control of the disease in the animals, as exemplified by the impact that the early measures adopted in the beginning of the 20th century forbidding the consumption of goat milk had on the prevalence of the disease in the British soldiers in Malta. When the prevalence of the disease in the animal population is high or when eradication cannot be achieved due to other factors (e.g., lack of economic resources), its control in livestock must be the first objective. When deciding the optimal approach to tackle the disease, the prevalence of animal brucellosis is not the only parameter to consider by the decision makers since other epidemiological and economic aspects should be considered in order to implement the most adequate control strategy in each region. Cooperation between all stakeholders involved is a cornerstone in the success of any control strategy. Strict biosafety and management measures, vaccination, and test-and-slaughter strategy are recognized as the most ef

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Control ofbrucella melitensis infection in sheep and goats—a review

Alton¹

1987

Trop Anim Health Prod

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Vaccination of adult sheep with reduced doses ofBrucella Melitensis strain rev. 1

Cited by 10 publications

References 3 publications

Vaccines for Caprine Brucellosis: Status and Prospective

Vaccines for Caprine Brucellosis: Status and Prospective

Control of Animal Brucellosis — The Most Effective Tool to Prevent Human Brucellosis

Control ofbrucella melitensis infection in sheep and goats—a review

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