Vaccination of Broiler Chicks from Breeder Flocks Immunized with a Live or Inactivated Oil Emulsion Newcastle Disease Vaccine ,

Eidson, C. S.; Thayer, Stephan G.; Villegas, Pedro; Kleven, S. H.

doi:10.3382/ps.0611621

Cited by 18 publications

(19 citation statements)

References 12 publications

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“…71, 2450.37, 2218.579, 2152.352, 1125.846 respectively. These finding were in agreement with Edison et al (1982), Ernawati and Ibrahim (1984), Diaon et al, (1998), Rahman et al, (2004) and Molia et al. (2011).…”

Section: Discussionsupporting

confidence: 82%

Development of BHK-21 Cell line Adapted Inactivated Newcastle Disease Vaccine

et al. 2014

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The present study was undertaken to isolate and characterize Newcastle disease virus (NDV) from the outbreak of layer farms for the development of BHK-21 cell adapted inactivated vaccine. A total of 6 dead birds were brought to the laboratory from the outbreak area from which 18 samples (trachea, liver and brain from each) were collected. Among them 3 samples were found positive for NDV through chicken embryo inoculation followed by HA test. The MDT, ICPI, IVPI of all isolates was 54.4, 1.56, and 2.20 respectively which revealed that the field isolates were velogenic. The isolated viruses were confirmed as NDV by reverse transcription-polymerase chain reaction (RT-PCR) using fusion gene-specific primers. The isolated virus was used to infect the BHK-21 cell line. Later the BHK-21 cell adapted viruses were used to develop oil adjuvanted inactivated vaccine and were inoculated into chickens according to vaccination schedule. The MDA was very high (112±29.62) during BCRDV vaccination, which declined quickly (88±33.12). Before vaccination with experimental vaccine, the level of antibody titre (HI) was very low (9±4.65). After vaccination at 65 th day through IM, ELD50=109.7/ml with experimental vaccine, the highest HI titre in RDV vaccinated group was 160±59.25 whereas, experimental vaccinated group was 128±59.25, and control group was 7±4.65. ELISA antibody titres of all the groups were 2549.71 (RDV, LRI@0.5 ml/bird), 2450.37 (experimental@ 0.25ml/ bird), 2218.579 (experimental@ 0.50ml/bird), 2152.352 (experimental@1ml/bird) 1125.846 (control) respectively. The present study indicated that, BHK-21 cell adapted ND inactivated vaccine produced a satisfactory antibody titre along with conventional live RDV vaccine.

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Section: Discussionsupporting

confidence: 82%

Development of BHK-21 Cell line Adapted Inactivated Newcastle Disease Vaccine

et al. 2014

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“…After blood sampling, each bird was injected subcutaneously in the back of the neck with 0·25 mL of an inactivated vaccine against Newcastle disease virus (NDV; Nobivac PMV, Intervet SA, Beaucouze, France). This vaccine dose corresponds to the standard volume recommended for chickens and pigeons (Eidson et al . 1982).…”

Section: Methodsmentioning

confidence: 99%

Evidence of an interannual effect of maternal immunization on the immune response of juveniles in a long‐lived colonial bird

Staszewski

Gasparini

McCoy

et al. 2007

Journal of Animal Ecology

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Summary 1.Little is known about the maternal transfer of antibodies in natural host-parasite systems despite its possible evolutionary and ecological implications. In domestic animals, the maternal transfer of antibodies can enhance offspring survival via a temporary protection against parasites, but it can also interfere with the juvenile immune response to antigens. 2. We tested the functional role of maternal antibodies in a natural population of a long-lived colonial seabird, the kittiwake ( Rissa tridactyla ), using a vaccine (Newcastle disease virus vaccine) to mimic parasite exposure combined with a cross-fostering design. 3. We first investigated the role of prior maternal exposure on the interannual transmission of Ab to juveniles. We then tested the effect of these antibodies on the juvenile immune response to the same antigen. 4. The results show that specific maternal antibodies were transferred to chicks 1 year after maternal exposure and that these antibodies were functional, i.e. they affected juvenile immunity. These results suggest that the role of maternal antibodies may depend on the timing and pattern of offspring exposure to parasites, along with the patterns of maternal exposure and the dynamics of her immune response. 5. Overall, our approach underlines that although the transgenerational transfer of antibodies in natural populations is likely to have broad implications, the nature of these effects may vary dramatically among host-parasite systems, depending on the physiological mechanisms involved and the ecological context.

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“…1) by injecting Ab isolated from immunized mothers into the egg yolks of unchallenged mothers and examined the effect on chick protection. We predicted that the Ab transferred would affect the chick immune response when re‐exposed to the same antigen that the mothers were exposed to, Newcastle Disease Virus (NDV) vaccine, in particular blocking the chick’s immune response as previously described with the same (Eidson et al. 1982; Staszewski et al.…”

Section: Introductionmentioning

confidence: 99%

Antibody injection in the egg yolk: maternal antibodies affect humoral immune response of the offspring

Staszewski

Siitari

2010

Functional Ecology

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Summary1. In vertebrate species, maternal antibodies specific for the pathogens to which mothers have been exposed can be transmitted to offspring before birth. This is assumed to be adaptive as these antibodies can be essential in protecting offspring early in life before their own immune system is fully developed. However, fitness consequences in natural conditions and the long-term effects of these mechanisms have yet to be fully examined. 2. Exploring the ecological and evolutionary implications of such maternal effects requires experimental manipulations to avoid potential confounding maternal effects. In birds, maternal antibodies are transmitted via the egg yolk -a self contained embryonic environment in which antibodies can be manipulated independently outside the maternal environment. 3. Here we use a novel technique to extract and experimentally manipulate maternal antibodies in the egg. Using the common quail (Coturnix coturnix), we demonstrate a blocking effect of antigen specific maternal antibodies received via egg injection, on the offspring's antibody response to an immune challenge with this antigen. Our results also suggest lower antibody production after a second immune challenge if maternal antibodies were present during first infection. 4. Maternal antibodies thus have the potential to affect the development of offspring immunity. Our innovative technique will enable further work to manipulate the transfer of maternal antibodies per se whilst controlling for confounding effects linked to maternal vaccination. Because it also enables to manipulate the amount of antibodies transferred, it will facilitate further study of their adaptive value and ecological consequences in natural host-parasite systems.

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Vaccination of Broiler Chicks from Breeder Flocks Immunized with a Live or Inactivated Oil Emulsion Newcastle Disease Vaccine ,

Cited by 18 publications

References 12 publications

Development of BHK-21 Cell line Adapted Inactivated Newcastle Disease Vaccine

Development of BHK-21 Cell line Adapted Inactivated Newcastle Disease Vaccine

Evidence of an interannual effect of maternal immunization on the immune response of juveniles in a long‐lived colonial bird

Antibody injection in the egg yolk: maternal antibodies affect humoral immune response of the offspring

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