Vaccination of dairy cows with recombinant Streptococcus uberis adhesion molecule induces antibodies that reduce adherence to and internalization of S. uberis into bovine mammary epithelial cells

Prado, Maria E; Almeida, Ricardo Augusto Monteiro de Barros; Özen, Can; Luther, Douglas A.; Lewis, Marion; Headrick, Susan I.; Oliver, S. P.

doi:10.1016/j.vetimm.2011.02.023

Cited by 28 publications

(32 citation statements)

References 24 publications

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“…Alternative approaches to vaccine development have been explored since, including attempts to produce antibodies that would interfere with the metabolic needs of the bacteria and bacterial growth, for example, by binding plasminogen activator A (PauA) (Leigh, ). Others have focussed on production of antibodies that would interfere with binding of S. uberis to mammary epithelial cells, which is mediated by the S. uberis adhesion molecule (SUAM; Almeida et al., ; Prado et al., ). Antibodies induced through vaccination with recombinant SUAM inhibit adherence and internalization of S. uberis into mammary epithelial cells in vitro, but the importance of this mechanism is debated (Günther et al., ; Prado et al., ).…”

Section: Prevention Detection and Controlmentioning

confidence: 99%

“…Others have focussed on production of antibodies that would interfere with binding of S. uberis to mammary epithelial cells, which is mediated by the S. uberis adhesion molecule (SUAM; Almeida et al., ; Prado et al., ). Antibodies induced through vaccination with recombinant SUAM inhibit adherence and internalization of S. uberis into mammary epithelial cells in vitro, but the importance of this mechanism is debated (Günther et al., ; Prado et al., ). Although pauA and sua genes are highly prevalent and highly conserved across strains of S. uberis (Perrig et al., ), mastitis can be caused by strains that are negative for pauA or contain frameshift mutations in sua , emphasizing the challenges posed by heterogeneity of the species (Gilchrist et al., ; Tassi et al., ).…”

Section: Prevention Detection and Controlmentioning

confidence: 99%

See 1 more Smart Citation

An update on environmental mastitis: Challenging perceptions

Klaas

Zadoks

2017

Transbound Emerg Dis

197

144

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Section: Prevention Detection and Controlmentioning

confidence: 99%

Section: Prevention Detection and Controlmentioning

confidence: 99%

An update on environmental mastitis: Challenging perceptions

Klaas

Zadoks

2017

Transbound Emerg Dis

197

144

View full text Add to dashboard Cite

show abstract

“…uberis adhesion molecule SUAM have all been examined for their ability to provide protection against Strep. uberis mastitis (Leigh et al, 1999;Prado et al, 2011;Song et al, 2017). However, it must be noted that while the prevalence of the gapC, sua, and pauA genes among bovine Strep.…”

Section: Vaccinesmentioning

confidence: 99%

Symposium review: Intramammary infections—Major pathogens and strain-associated complexity

Keane

2019

Journal of Dairy Science

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Intramammary infection (IMI) is one of the most costly diseases to the dairy industry. It is primarily due to bacterial infection and the major intramammary pathogens include Escherichia coli, Streptococcus uberis, and Staphylococcus aureus. The severity and outcome of IMI is dependent on several host factors including innate host resistance, energy balance, immune status, parity, and stage of lactation. Additionally, the infecting organism can influence the host immune response and progression of disease. It is increasingly recognized that not only the infecting pathogen species, but also the strain, can affect the transmission, severity, and outcome of IMI. For each of 3 major IMI-associated pathogens, S. aureus, Strep. uberis, and E. coli, specific strains have been identified that are adapted to the intramammary environment. Strain-dependent variation in the host immune response to infection has also been reported. The diversity of strains associated with IMI must be considered if vaccines effective against the full repertoire of mammary pathogenic strains are to be developed. Although important advances have been made recently in understanding the molecular mechanism underpinning strain-specific virulence, further research is required to fully elucidate the cellular and molecular pathogenesis of mammary adapted strains and the role of the strain in influencing the pathophysiology of infection. Improved understanding of molecular pathogenesis of strains associated with bovine IMI will contribute to the development of new control strategies, therapies, and vaccines. The development of enabling technologies such as pathogenomics, transcriptomics, and proteomics can facilitate system-level studies of strain-specific molecular pathogenesis and the identification of key mediators of host-pathogen interactions.

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“…Since Hill [98] showed that previous exposure to S. uberis could provide some resistance to infection against the same strain, several trials with a broad variety in efficiency were performed to identify potential vaccine candidates against S. uberis mastitis: i. e. the plasminogen activator PauA as a total antigen as well as a PauA depleted antigen [99], recombinant S. uberis GapC or a chimeric CAMP antigen [100], recombinant S. uberis adhesion molecule [101] as well as S. uberis bacterin [102] etc. Until now there is still a lack of vaccine which is able to control infection without the participation of a marked inflammatory response.…”

Section: Vaccinationmentioning

confidence: 99%

Bovine Streptococcus uberis Intramammary Infections and Mastitis

Krömker¹

2014

Clin Microbial

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Streptococcus (S.) uberis is a causative agent for clinical and subclinical bovine mastitis which significance for the udder health has increased over the last decades. Molecular diagnosis methods revealed that S. uberis may be subdivided into many different varieties with different epidemiological properties. In addition, some varieties were reclassified as Streptococcus parauberis and Globicatella sanguinis. The present paper reviews S. uberis and its role in modern dairy farming. This pathogen is ubiquitous for which it is considered as environment-associated. Straw bedding and pasture, but also the bovine skin and digestive mucosae are typical localizations inhabited by S. uberis. Due to its capacity to persist within the mammary tissue, some infections may eventually turn cow-associated. In other cases, the infection is short, but in any case, there is a high risk of re-infection. Although many varieties remain susceptible to most antimicrobial agents, the problem for the dairy farm lies in the high rate of re-infection. This paper also reviews risk factors, therapies and measures to control S. uberis at farm level.

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Vaccination of dairy cows with recombinant Streptococcus uberis adhesion molecule induces antibodies that reduce adherence to and internalization of S. uberis into bovine mammary epithelial cells

Cited by 28 publications

References 24 publications

An update on environmental mastitis: Challenging perceptions

An update on environmental mastitis: Challenging perceptions

Symposium review: Intramammary infections—Major pathogens and strain-associated complexity

Bovine Streptococcus uberis Intramammary Infections and Mastitis

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