Vaccination of pigs reduces Torque teno sus virus viremia during natural infection

Jiménez-Melsió, Alexandra; Rodrı́guez, Fernando; Darji, Ayub; Segalés, Joaquím; Cornelissen-Keijsers, Vivian; Born, Erwin van den; Kekarainen, Tuija

doi:10.1016/j.vaccine.2015.05.064

Cited by 5 publications

(1 citation statement)

References 36 publications

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“…A conformational change in the precise site of dominant epitopes can have a relevant impact in immune function, particularly on immunoglobulin production. It has been found that several IgGs are able to bind to ORF1 (Singh & Ramamoorthy, ; Jarasova & Celer, ; Liu et al., ; Giménez‐Lirola et al., ; Nieto, Martínez‐Guinó, Jiménez‐Melsio, Segalés, & Kekarainen, ) and ORF2 products (Jiménez‐Melsió et al., ) from TTSuV1a and TTSuV1b.…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of the ORF2 of Torque teno sus virus 1a and Torque teno sus virus 1b detected in cases of postweaning multisystemic wasting syndrome in Mexico

Vargas-Ruiz¹,

García-Camacho²,

Álvarez³

et al. 2018

Transbound Emerg Dis

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Worldwide Torque teno sus virus (TTSuV, genus Iotatorquevirus) species have been regarded as possible agents associated with porcine circovirus-associated disease. Iotatorquevirus species possess high genomic variability, suggesting that diverse genotypes are widely geographically distributed. In this study, we validated the genomic variability of Iotaroquevirus species in pigs with postweaned multisystemic wasting syndrome. Genomic DNA from nine TTSuV1a-positive tissues and 15 TTSuV1b-positive tissues was used to amplify the complete ORF2 of each species by nested PCR to perform a molecular characterization. It was found that Mexican TTSuV1a sequences belong to genotype B, sharing phylogenetic origin, high nucleic acid and amino acid sequence similarity and dominant epitope conformation with commercially linked countries, such as the United States, Canada and China, whereas the Mexican TTSuV1b sequences belong to genotype A, being more divergent among each other and displaying low nucleotide identity with worldwide genotype A sequences. In both Iotatorquevirus species, a PTPase-like signature motif was identified in the predicted amino acid sequence, being more conserved for Mexican TTSuV1b sequences than for Mexican TTSuV1a sequences, in which several substitutions were observed. These changes may influence the conformation of dominant epitopes as different arrays were determined among TTSuV1a genotypes. ORF2 variability may account for pathogenic differences by modifying viral replication and immune response, as depicted for human TTV.

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