Vaccination of rabbits with a bovine herpesvirus type 1 subunit vaccine: adjuvant effect of ISCOMs

Trudel, Michel; Nadon, Francine; Séguin, Cécile; Boulay, Gaston; Lussier, G

doi:10.1016/0264-410x(87)90108-3

Cited by 22 publications

(13 citation statements)

References 18 publications

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“…Antigens that are derived from purified organisms or cell membranes and have the ability to incorporate into ISCOMs are generally proteins, glycoproteins, or lipoproteins that are normally anchored into the cell or viral membrane by a hydrophobic transmembrane sequence or by lipid [3,12,13,[28][29][30]. When ISCOMs are made, these molecules are extracted by detergent treatment and integrate into the lipid-saponin matrix when the detergent is removed and ISCOM particles form [13,16].…”

Section: Protein Association With Iscoms and Iscom Matrixmentioning

confidence: 99%

ISCOMs: an adjuvant with multiple functions

Sjölander

Cox

Barr

1998

Journal of Leukocyte Biology

158

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Section: Protein Association With Iscoms and Iscom Matrixmentioning

confidence: 99%

ISCOMs: an adjuvant with multiple functions

Sjölander

Cox

Barr

1998

Journal of Leukocyte Biology

158

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“…Differentiation between vaccinated and infected cattle on the basis of serology is possible when subunit vaccines are used that selectively incorporate certain proteins. Iscoms containing the envelope glycoproteins of BHVl were shown to be immunogenic in rabbits (Trudel et al, 1987) and calves (Trudel et al, 1988a;Merza et al, 1991a). Both species developed virus-neutralizing and haemagglutination-inhibiting antibodies.…”

Section: Protective Immune Responses Against Viruses Induced By Iscommentioning

confidence: 99%

“…Quil A is a necessary constituent of the iscom structure. The size and morAntigen nature Name Mowatt et al, 1991a/b Lovgren et al, 1987Erturk et al, 1989Trudel et al, 1987, 1988Wahren et al, 1987Tsuda et al, 1991Morgan et al, 1988Howard et al, 1987Trudel et al, 1988Carlson et al, 1991De Vries et al, 1988aDe Vries et al, 1988bVisser et al, 1989Trudel et al, 1989Trudel et al, 1992Fedaku et al, 1992Jones et al, 1988Merza et al, 1991Osterhaus et al, 1992Takehashi et al, 1990Pyle et al, 1989Nagy et al, 1990Winter et al, 1988…”

mentioning

confidence: 99%

The iscom structure as an immune-enhancing moiety: experience with viral systems

Claassen

Osterhaus

1992

Research in Immunology

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“…(1987), Trudel et al (1987), Elguink (1989), Tan et al (1989), Brynestad et al (1990), Gregoriadis (1990) and Lovgren and Morein (1991).…”

mentioning

confidence: 99%

“…Specific prophylaxis of this worldwide occurring disease has been limited to the use of live and inactivated vaccines, prepared from the virus propagated in cell cultures. Development of subunit vaccines, as a way of improving their efficacy and quality, has become a topical task (Trudel et al 1987(Trudel et al , 1988Merza et al 1988).…”

mentioning

confidence: 99%

Incorporation of Bovine Herpesvirus 1 Protein Subunits into Large Unilamellar and Multilamellar Liposomes

Hampl¹,

Štěpánek²,

Fränz³

et al. 1992

Acta Vet. Brno

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Hampl J., J. StC!panek, J. FranZ Acta vet. Bmo, 61, 1992: 29-36. Virus proteins, obtained by the treatment of purified bovine herpesvirus 1 with detergents, were incorporated into large unilamellar (LUV) and multilamellar (MLV) liposomes. Their antigenicity was compared with that of virus proteins adsorbed onto LUV surface in mice. Both antibody levels and dynamics of antibody responses, examined by ELISA and RIA, confirmed a marked immunostimulatory effect of the liposomes. The most pronounced antibody responses were observed in animals injected with virus proteins incorporated into LUV, prepared from egg phospholipid, or adsorbed onto their surface. BOfJine herpesT.Jirus 1, fJirus proteins, antibody response, large unilamellar liposomes, multilamellar liposomesOne of the current innovation trends in the production of vaccines against virus diseases of farm animals is the development of subunit vaccines. The principle consists in the selection from the whole complex of virus structural proteins of those, which elicit an immune response providing the protection of vaccinates (protective antigens). The question whether the proteins are obtained by degradation of complete virus particles, propagated by conventional methods, or are prepared in vitro by techniques of molecular biology, is irrelevaIit.A common drawback, limiting the immediate use of such proteins, is their rather weak immunogenicity, which is much lower than that of the same proteins as a part of complete virion structures. All attempts to compensate for this drawback by the use of current non-specific immunostimulants or adiuvants have failed (Dougan 1985;Rowland 1986;Zanetti et al. 1987; Liu and Cepica 1990).A certain effect was evident, however, when the protein subunits were incorporated back into multimolecular, corpuscular structures, such as ISCOMs (immunity stimulating complex), or various types of liposomes. In both cases, the size and shape of the particles resemble those of virions.Enhancement of antigenicity of proteins, incorporated into ISCOMs or liposomes, was reported by

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Vaccination of rabbits with a bovine herpesvirus type 1 subunit vaccine: adjuvant effect of ISCOMs

Cited by 22 publications

References 18 publications

ISCOMs: an adjuvant with multiple functions

ISCOMs: an adjuvant with multiple functions

The iscom structure as an immune-enhancing moiety: experience with viral systems

Incorporation of Bovine Herpesvirus 1 Protein Subunits into Large Unilamellar and Multilamellar Liposomes

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