Vaccination Strategies in a Potential Use of the Vaccine against Bovine Tuberculosis in Infected Herds

Milián-Suazo, Feliciano; González-Ruiz, Sara; Contreras-Magallanes, Yesenia Guadalupe; Sosa-Gallegos, Susana L.; Bárcenas-Reyes, Isabel; Cantó-Alarcón, Germinal Jorgé; Rodríguez-Hernández, Elba

doi:10.3390/ani12233377

Cited by 9 publications

(8 citation statements)

References 119 publications

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“…Infected animals can suffer reduced productivity, and control measures can burden farmers and governments economically. Additionally, trade restrictions on livestock and livestock products due to bovine tuberculosis concerns can impact international trade relationships [5,46]. Bovine tuberculosis is a zoonotic disease that can be transmitted between animals and humans.…”

Section: Discussionmentioning

confidence: 99%

“…While cattle (bovines) are considered the primary reservoir for Mycobacterium bovis, other animals like goats, buffaloes, dogs, primates, ferrets, opossums, and even endangered species like the white 2 rhinoceros can also be susceptible to infection [3,4]. In some cases, these animals can contract the disease from contact with infected cattle or contaminated environments [5].…”

Section: Introductionmentioning

confidence: 99%

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Mapping of Bovine Tuberculosis in Colombia, 2001-2019

Bonilla-Aldana,

Jiménez-Diaz,

Losada

et al. 2024

Preprint

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Introduction: Bovine tuberculosis is a zoonotic disease of considerable impact, especially in livestock countries, which can cause human disease. Despite its importance, Colombia is a country in which few studies analyse its behaviour, and none develop maps using geographic information systems to characterise it. Objective: To describe the temporal-spatial distribution of bovine tuberculosis in Colombia between 2001 and 2019. Methods: Retrospective cross-sectional descriptive study, based on reports by the Colombian Agricultural Institute, of tuberculosis surveillance in cattle on farms in Colombia from 2001 to 2019. The data were converted into databases in Microsoft Access 365®, and multiple epidemiological maps were generated with the Kosmo RC1®3.0 software coupled to shape files of all the country's departments. Results: During the study period, 5,273 tuberculosis cases in bovines were identified in the different departments of Colombia (mean 278 cases/year). Regarding its temporal distribution, the number of cases varied from a maximum of 903 cases (17.12% of the total) in 2015 to a minimum of 0 between 2001 and 2004 and between 2017 and 2019 (between 2005 and 2016, the minimum was 46 cases, 0.87%). Conclusions: GIS is an essential tool for understanding the temporospatial behaviour of zoonotic diseases in Colombia, as is the case of bovine tuberculosis, with its potential implications for Human and One Health.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mapping of Bovine Tuberculosis in Colombia, 2001-2019

Bonilla-Aldana,

Jiménez-Diaz,

Losada

et al. 2024

Preprint

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“…In animal populations, disease control is achieved through test and slaughter policies in many countries. Although BCG vaccination in cattle is effective [35], and strategies for deployment have been considered [36], the use of vaccines has been constrained in cattle because the use of BCG compromises the TST. Deployment in many countries will probably depend on developing a complementary DIVA test to differentiate infected from vaccinated animals [37].…”

Section: Preventionmentioning

confidence: 99%

Mycobacterium bovis and its impact on human and animal tuberculosis

Sawyer,

Rhodes,

Jones

et al. 2023

Journal of Medical Microbiology

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Graphical abstract Mycobacterium bovis is a slow-growing (16–20 h generation time), Gram-positive and acid-fast bacterium member of the Mycobacterium tuberculosis complex pathogen group (MTBC). They are characterized by a complex, protective cell wall containing mycolic acids. The MTBCs are the causative agents of tuberculosis (TB). Following initial infection, subsequent pathological changes, and the progress of infection depend on the interplay between host defence mechanisms and mycobacterial virulence factors and the balance between the immunologic protective responses and the damaging inflammatory processes. Progression of the disease is characterized by the formation of typical caseous tuberculous granuloma (inflammatory mononuclear cell aggregates) because of the host's immune response to infection. The transmission and epidemiology of Mycobacterium bovis are complex and vary depending on the situation and ecosystem. In the UK, the spread of BTB in the UK cattle herd can occur by transmitting the disease from cattle to cattle and between badgers but also between badgers and cattle. The disease is thought to be primarily a respiratory disease with spread between individuals through mechanisms such as coughing or transfer of bacteria in respiratory secretions. It is also thought that environmental contamination may also lead to some transmission. The protective cell wall of the organism is believed to allow the organism to survive outside an animal host, which can then transfer to new hosts following subsequent environmental exposure. In some situations, ingestion of pathogens in food can lead to infection. The relative contribution of these routes and precise transmission mechanisms needs to be better understood.

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“…Successful DIVA technologies has been developed for animal vaccines like bovine rhinotracheitis (IBR), pseudo rabies, Classical Swine Fever (CSF) etc [24]. Strategies for developing DIVA based vaccines for other diseases like bovine tuberculosis [25,26], avian influenza [27], PPR [28] and bluetongue virus [29] are also under development.…”

Section: Available Diva Vaccines For Farm Animalsmentioning

confidence: 99%

Review on Discriminatory Tests of Immune Reaction due to Infection and Vaccination (DIVA Test)

2023

austinjvetscianimhusb

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In concern for animal diseases, the goal of vaccination is to prevent or reduce clinical diseases associated with the infectious agent, but it can also be used as a means of managing or eradicating a disease from a particular region. Therefore it is essential to differentiate immune responses due to vaccination compared to natural infection. It was to satisfy this requirement that the term Differentiation of Infected from Vaccinated Animals (DIVA) was coined in 1999 by Jan T van Oirschot. DIVA principle is based on a DIVA vaccine producing an antibody response that is different from the antibody response produced by the wild-type virus. The DIVA approach has been applied and proposed successfully to various diseases. Although considerable progress has been made to evaluate which different DIVA strategies are most likely to be applicable in the field, considerably more work needs to be done. If properly applied, DIVA vaccination strategies promise to provide new tools for the control and eradication of diseases.

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Vaccination Strategies in a Potential Use of the Vaccine against Bovine Tuberculosis in Infected Herds

Cited by 9 publications

References 119 publications

Mapping of Bovine Tuberculosis in Colombia, 2001-2019

Mapping of Bovine Tuberculosis in Colombia, 2001-2019

Mycobacterium bovis and its impact on human and animal tuberculosis

Review on Discriminatory Tests of Immune Reaction due to Infection and Vaccination (DIVA Test)

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