Vaccination to gain humoral immune memory

Sarkander, Jana; Hojyo, Shintaro; Tokoyoda, Koji

doi:10.1038/cti.2016.81

Cited by 43 publications

(32 citation statements)

References 66 publications

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“…Humoral adaptive immunity to pre-erythrocytic stages. Successful vaccines against most infectious diseases rely on the generation of effective class-switched, affinity-matured Abs against the disease-causing pathogen (88). Early evidence for the role of Abs in pre-erythrocytic immunity comes from studies using RAS-immunized mice in which Abs against sporozoite surface proteins were protective against parasite challenge (89).…”

Section: Pre-erythrocytic Immunity: Lessons From Whole-sporozoite Vacmentioning

confidence: 99%

Designer Parasites: Genetically Engineered Plasmodium as Vaccines To Prevent Malaria Infection

Goswami

Minkah

Kappe

2019

The Journal of Immunology

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A highly efficacious malaria vaccine that prevents disease and breaks the cycle of infection remains an aspirational goal of medicine. Whole parasite vaccines based on the sporozoite forms of the parasite that target the clinically silent pre-erythrocytic stages of infection have emerged as one of the leading candidates. In animal models of malaria, these vaccines elicit potent neutralizing Ab responses against the sporozoite stage and cytotoxic T cells that eliminate parasite-infected hepatocytes. Among whole-sporozoite vaccines, immunization with live, replication-competent whole parasites engenders superior immunity and protection when compared with live replication-deficient sporozoites. As such, the genetic design of replication-competent vaccine strains holds the promise for a potent, broadly protective malaria vaccine. In this report, we will review the advances in whole-sporozoite vaccine development with a particular focus on genetically attenuated parasites both as malaria vaccine candidates and also as valuable tools to interrogate protective immunity against Plasmodium infection.

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Section: Pre-erythrocytic Immunity: Lessons From Whole-sporozoite Vacmentioning

confidence: 99%

Designer Parasites: Genetically Engineered Plasmodium as Vaccines To Prevent Malaria Infection

Goswami

Minkah

Kappe

2019

The Journal of Immunology

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“…Studies are in progress to examine how BM plasma cell numbers change after immunization with the seasonal influenza vaccine. A subsequent discussion focused on how infection and vaccination differ in generating long-lived immunity (33,34). It is known that humans infected with influenza virus decades previously possess circulating Abs reactive to the original infecting strain.…”

Section: Influenza Vaccinesmentioning

confidence: 99%

Waning Immunity and Microbial Vaccines—Workshop of the National Institute of Allergy and Infectious Diseases

Plotkin

Edwards

et al. 2017

Clin Vaccine Immunol

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Since the middle of the 20th century, vaccines have made a significant public health impact by controlling infectious diseases globally. Although long-term protection has been achieved with some vaccines, immunity wanes over time with others, resulting in outbreaks or epidemics of infectious diseases. Long-term protection against infectious agents that have a complex life cycle and antigenic variation remains a key challenge. Novel strategies to characterize the short-and long-term immune responses to vaccines and to induce immune responses that mimic natural infection have recently emerged. New technologies and approaches in vaccinology, such as adjuvants, delivery systems, and antigen formulations, have the potential to elicit more durable protection and fewer adverse reactions; together with in vitro systems, these technologies have the capacity to model and accelerate vaccine development. The National Institute of Allergy and Infectious Diseases (NIAID) held a workshop on 19 September 2016 that focused on waning immunity to selected vaccines (for Bordetella pertussis, Salmonella enterica serovar Typhi, Neisseria meningitidis, influenza, mumps, and malaria), with an emphasis on identifying knowledge gaps, future research needs, and how this information can inform development of more effective vaccines for infectious diseases.

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“…Hence, vaccine efficacy in the long run is influenced by the determinants of immunological memory stimulation, persisting antibodies and kind and type of immune memory cells induced. 14 The primary vaccine-mediated immunological effectors (Table 1) are mainly the antibodies (from B lymphocytes/ cell) 15,16 and sometimes CD8+ and CD4+ T cells. These antibodies bind specifically to a particular kind of toxin or…”

Section: Vaccine Immunology and Designmentioning

confidence: 99%

<p>Immunoinformatics and Vaccine Development: An Overview</p>

Oli

Obialor

Ifeanyichukwu

et al. 2020

ITT

177

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The use of vaccines have resulted in a remarkable improvement in global health. It has saved several lives, reduced treatment costs and raised the quality of animal and human lives. Current traditional vaccines came empirically with either vague or completely no knowledge of how they modulate our immune system. Even at the face of potential vaccine design advance, immune-related concerns (as seen with specific vulnerable populations, cases of emerging/reemerging infectious disease, pathogens with complex lifecycle and antigenic variability, need for personalized vaccinations, and concerns for vaccines' immunological safety -specifically vaccine likelihood to trigger non-antigen-specific responses that may cause autoimmunity and vaccine allergy) are being raised. And these concerns have driven immunologists toward research for a better approach to vaccine design that will consider these challenges. Currently, immunoinformatics has paved the way for a better understanding of some infectious disease pathogenesis, diagnosis, immune system response and computational vaccinology. The importance of this immunoinformatics in the study of infectious diseases is diverse in terms of computational approaches used, but is united by common qualities related to host-pathogen relationship. Bioinformatics methods are also used to assign functions to uncharacterized genes which can be targeted as a candidate in vaccine design and can be a better approach toward the inclusion of women that are pregnant into vaccine trials and programs. The essence of this review is to give insight into the need to focus on novel computational, experimental and computation-driven experimental approaches for studying of host-pathogen interactions and thus making a case for its use in vaccine development.

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Vaccination to gain humoral immune memory

Cited by 43 publications

References 66 publications

Designer Parasites: Genetically Engineered Plasmodium as Vaccines To Prevent Malaria Infection

Designer Parasites: Genetically Engineered Plasmodium as Vaccines To Prevent Malaria Infection

Waning Immunity and Microbial Vaccines—Workshop of the National Institute of Allergy and Infectious Diseases

<p>Immunoinformatics and Vaccine Development: An Overview</p>

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