Vaccination Trials Against Bovine Herpesvirus-1

Castrucci, G; Ferrari, M; Salvatori, Daniela; Sardonini, S; Frigeri, F; Petrini, Stefano; Dico, M Lo; Marchini, Cristina; Rotola, Antonella; Amici, Augusto; Provinciali, Mauro; Tosini, A.; Angelini, Raffaella; Cassai, Enzo

doi:10.1007/s11259-005-0049-6

Cited by 4 publications

(2 citation statements)

References 6 publications

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“…In 1999, Brillowska et al [32] generated an effective cellular immune response with the plasmid encoding the envelope glycoprotein gp51 and the transmembrane glycoprotein gp30 of the bovine leukemia virus (BLV), and a DNA vaccine encoding the fusion (F) gene of bovine respiratory syncytial virus (BRSV) induced protection against the infection in calves. Protective DNA vaccine strategies were identified against bovine herpes virus-1 (BHV-1) infection [33,34], and DNA immunization using the gC gene of BHV-1 induced both neutralizing antibodies and lympho-proliferative responses in bovines [35].…”

Section: Veterinary Applicationsmentioning

confidence: 99%

The Key Role of Nucleic Acid Vaccines for One Health

Fomsgaard

Liu²

2021

Viruses

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The ongoing SARS-CoV-2 pandemic has highlighted both the importance of One Health, i.e., the interactions and transmission of pathogens between animals and humans, and the potential power of gene-based vaccines, specifically nucleic acid vaccines. This review will highlight key aspects of the development of plasmid DNA Nucleic Acid (NA) vaccines, which have been licensed for several veterinary uses, and tested for a number of human diseases, and will explain how an understanding of their immunological and real-world attributes are important for their efficacy, and how they helped pave the way for mRNA vaccines. The review highlights how combining efforts for vaccine development for both animals and humans is crucial for advancing new technologies and for combatting emerging diseases.

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Section: Veterinary Applicationsmentioning

confidence: 99%

The Key Role of Nucleic Acid Vaccines for One Health

Fomsgaard

Liu²

2021

Viruses

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“…Also, DNA vaccine encoding the fusion (F) gene of bovine respiratory syncytial virus (BRSV) has been found to induce protection against the infection in calves. Besides, several workers have developed successful DNA vaccine strategies against bovine herpes virus-1 (BHV-1) infection (Loehr et al 2001;Gupta et al 2001;Castrucci et al 2005). Gupta et al (2001) reported that DNA immunization with gC gene of BHV-1 could induce neutralizing antibody and lympho-proliferative responses in bovines.…”

Section: Applications Of Nucleic Acid Vaccines In Veterinary Practicementioning

confidence: 99%

DNA vaccines and their applications in veterinary practice: current perspectives

et al. 2008

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Inoculation of plasmid DNA, encoding an immunogenic protein gene of an infectious agent, stands out as a novel approach for developing new generation vaccines for prevention of infectious diseases of animals. The potential of DNA vaccines to act in presence of maternal antibodies, its stability and cost effectiveness and the non-requirement of cold chain have heightened the prospects. Even though great strides have been made in nucleic acid vaccination, still there are many areas that need further research for its wholesome practical implementation. Major areas of concern are vaccine delivery, designing of suitable vectors and cytotoxic T cell responses. Also, the induction of immune responses by DNA vaccines is inconclusive due to the lack of knowledge regarding the concentration of the protein expressed in vivo. Alternative delivery systems having higher transfection efficiency and the use of cytokines, as immunomodulators, needs to be further explored. Recently, efforts are being made to modulate and prolong the active life of dendritic cells, in order to make antigen presentation a more efficacious one. For combating diseases like acquired immunodeficiency syndrome (AIDS), influenza, malaria and tuberculosis in humans; and foot and mouth disease, Aujesky's disease, swine fever, rabies, canine distemper and brucellosis in animals, DNA vaccine clinical trials are underway. This review highlights the salient features of DNA vaccines, and measures to enhance their efficacy so as to devise an effective and novel vaccination strategy against animal diseases.

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