1990
DOI: 10.1128/jvi.64.3.1370-1374.1990
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Vaccination with inactivated influenza A virus during pregnancy protects neonatal mice against lethal challenge by influenza A viruses representing three subtypes

Abstract: A single intraperitoneal injection of pregnant mice with a monovalent Formalin-inactivated influenza A virus vaccine protected their offspring against a lethal challenge dose of the same influenza A virus H3N2, H2N2, and HlNl subtypes, as well as against challenge with the other two subtypes. Degree of protection was vaccine dose related. Cross-fostering of neonates indicated that protection was conferred by breast milk antibodies. Serum virus-specific neutralizing antibodies in the mothers and neonates correl… Show more

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Cited by 50 publications
(16 citation statements)
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“…The protection of young mammals from virus infections by specific maternal antibodies has been demonstrated in several species (Paul, 1983;Milner and Marshall, 1984;Sweet et al, 1987;Jakeman et al, 1989;Mbawuike et al, 1990). The three harbour seal newborns that obtained PDV-specific antibodies via colostrum/milk in our study have essentially been passively immunised against infection by morbilliviruses.…”
Section: Discussionmentioning
confidence: 59%
“…The protection of young mammals from virus infections by specific maternal antibodies has been demonstrated in several species (Paul, 1983;Milner and Marshall, 1984;Sweet et al, 1987;Jakeman et al, 1989;Mbawuike et al, 1990). The three harbour seal newborns that obtained PDV-specific antibodies via colostrum/milk in our study have essentially been passively immunised against infection by morbilliviruses.…”
Section: Discussionmentioning
confidence: 59%
“…Nohira (22) showed that the offspring of mice immune to relapsing fever borreliae had considerable immunity and claimed that the antibodies were transferred via the placenta. However, data regarding antibody transfer during spirochetal infection are not available except for Nohira's report, although similar studies of other bacterial and viral infections have been reported (14,19,25). In the case of type III group B streptococcal infection in suckling rats, the pups born to immunized mothers and fostered on nonimmunized mothers had a higher survival rate (98%) than those born to nonimmunized mothers and fostered on immunized mothers (66%) (13).…”
Section: Discussionmentioning
confidence: 91%
“…These data indicate that the protective antibodies specific to type III group B streptococci transferred via the yolk sac play a more important role than those transferred via milk. In contrast, it was shown by using cross-fostered infants that the maternal-fetal-neonatal transfer of influenza virus immunity was most probably mediated by breast milk antibodies (19,25). In the present study, the group 1 and 2 fostered offspring were completely protected against borrelial challenge ( Table 2) but 2 of 10 mice in group 3 showed incomplete immunity.…”
Section: Discussionmentioning
confidence: 99%
“…Immunization during later gestational periods shows higher maternal immune activation and transmission to the fetus, but quicker antibody waning in the mother versus vaccination during the first or second trimester (Cuningham et al 2019). For the fetus and neonate, passive transfer of antibodies via placenta or in breast milk can be protective; however, maternal vaccination during early pregnancy may wane and be ineffective in the neonate (Reuman et al 1983;Mbawuike et al 1990;Honda-Okubo et al 2014;van der Lubbe et al 2017;Cuningham et al 2019). The benefits of maternal vaccination on fetal and neonatal survival is also evident for H5N1 vaccination and challenge in mice, highlighting the benefits of breastfeeding for influenza-infected neonates and the uptake of vaccines in the pregnant cohort (Beigi et al 2009;Satpathy et al 2009;Hwang et al 2010;Steinhoff et al 2010;Christian et al 2017).…”
Section: Protecting High-risk Populationsmentioning
confidence: 99%