Vaccination with Trypanosoma rangeli modulates the profiles of immunoglobulins and IL-6 at local and systemic levels in the early phase of Trypanosoma cruzi experimental infection

Marini, Vanina; Moretti, Edgardo; Bermejo, Daniela A.; Basso, Beatriz

doi:10.1590/s0074-02762011000100005

Cited by 14 publications

(14 citation statements)

References 23 publications

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“…Meanwhile, Gr1 cells in conjunction with F4/80 cells, in addition active phagocytosis, might be responsible for generating an adverse environment for the parasite by releasing active O 2 metabolites, reducing pH, activating enzymes, among others, that would induce early lysis of the parasite as observed in earlier works (Marini et al, 2011;. Likewise the reduction of NK, F4/80 and Gr-1 cells observed at 24 h post-infection compared to their initial values might account for their marginalization in secondary lymphoid organs or tissues after exercising intense cytotoxic and phagocytic activity.…”

Section: Discussionmentioning

confidence: 66%

“…I. As observed in previous works(Basso et al, 1991;Marini et al, 2011), the parasitemia value in animals Please cite this article in press as: Basso, B., Marini, V., Experimental Chagas disease in Balb/c mice previously vaccinated with T. rangeli. II.…”

mentioning

confidence: 52%

“…in vaccinated animals. In earlier studies, high levels of specific antibodies were detected in animals immunized prior to infection, which remained until the end of the acute phase (Marini et al, 2011). Parallel to this, T lymphocytes are differentiated by being memory cells that trigger defence mechanisms, efficient in the face of a subsequent stimulation with the same antigen (Silva, 2010).…”

Section: Discussionmentioning

confidence: 91%

“…T. rangeli is not pathogenic to humans and both parasites present a high antigenic similarity (Basso et al, 1987(Basso et al, , 1989Grögl and Kuhn, 1984;Saldaña and Sousa, 1996). In previous works we have demonstrated that immunization with T. rangeli induces a strong adaptative immune response (Basso et al, 1991;Marini et al, 2011) before and after infection and does not induce autoimmune or histological alterations in the chronic period. Indeed, with a substantial modulation of the innate immune response, it contributed to a drastic elimination of parasites in the early hours post-infection (Basso and Marini, 2014).…”

Section: Introductionmentioning

confidence: 95%

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Experimental Chagas disease in Balb/c mice previously vaccinated with T. rangeli. II. The innate immune response shows immunological memory: Reality or fiction?

Basso

Marini

2015

Immunobiology

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Section: Discussionmentioning

confidence: 66%

mentioning

confidence: 52%

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 95%

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Experimental Chagas disease in Balb/c mice previously vaccinated with T. rangeli. II. The innate immune response shows immunological memory: Reality or fiction?

Basso

Marini

2015

Immunobiology

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“…According to Marini et al [ 25 ], immune responses with high levels of IgG1, IgG2a and IgG3 in the serum are important mechanisms that help eliminate microorganisms. This indicates that our results are promising for the development of an effective vaccine against CLA.…”

Section: Discussionmentioning

confidence: 99%

Corynebacterium pseudotuberculosiscp09 mutant and cp40 recombinant protein partially protect mice against caseous lymphadenitis

et al. 2014

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BackgroundCaseous lymphadenitis (CLA) is an infectious disease that affects small ruminants and is caused by Corynebacterium pseudotuberculosis. This disease is responsible for high economic losses due to condemnation and trim of infected carcasses, decreased leather and wool yield, loss of sales of breeding stock and deaths from internal involvement. Treatment is costly and ineffective; the most cost-effective strategy is timely immunisation. Various vaccine strategies have been tested, and recombinant vaccines are a promising alternative. Thus, in this study, different vaccine formulations using a recombinant protein (rCP40) and the CP09 live recombinant strain were evaluated. Five groups of 10 mice each were immunised with saline (G1), rCP40 (G2), CP09 (G3), a combination of CP09 and rCP40 (G4) and a heterologous prime-boost strategy (G5). Mice received two immunisations within 15 days. On day 30 after primary immunisation, all groups were challenged with a C. pseudotuberculosis virulent strain. Mice were monitored and mortality was recorded for 30 days after challenge.ResultsThe G2, G4 and G5 groups showed high levels of IgG1 and IgG2a; G2 presented significant IgG2a production after virulent challenge in the absence of IgG1 and IgG3 induction. Thirty days after challenge, the mice survival rates were 20 (G1), 90 (G2), 50 (G3), 70 (G4) and 60% (G5).ConclusionsrCP40 is a promising target in the development of vaccines against caseous lymphadenitis.

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Naegleria fowleri glycoconjugates with residues of α-d-mannose are involved in adherence of trophozoites to mouse nasal mucosa

et al. 2013

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We analyzed the possible role of glycoconjugates containing α-D-mannose and α-D-glucose residues in adherence of trophozoites to mouse nasal epithelium. Trophozoites incubated with 20 μg of one of three different lectins which preferentially recognized these residues were inoculated intranasally in Balb/c mice. Mouse survival was 40% with Pisum sativum and Canavalia ensiformis and 20% with Galanthus nivalis amebic pretreatment, compared with 0% survival for control animals administered trophozoites without pretreatment. Possibly some of the glycoproteins found in Naegleria fowleri represent an adherence factor. Differences in the saccharide sequences of the Naegleria species, even on the same glycoconjugate structure, could explain the different results corresponding to the distinct pretreatments (C. ensiformis, G. nivalis, and P. sativum). We found a higher expression of glycoconjugates recognized by P. sativum in Naegleria lovaniensis than N. fowleri, probably due to the higher number of oligosaccharides containing an α-1,6-linked fucose moiety expressed on the former species.

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Vaccination with Trypanosoma rangeli modulates the profiles of immunoglobulins and IL-6 at local and systemic levels in the early phase of Trypanosoma cruzi experimental infection

Cited by 14 publications

References 23 publications

Experimental Chagas disease in Balb/c mice previously vaccinated with T. rangeli. II. The innate immune response shows immunological memory: Reality or fiction?

Experimental Chagas disease in Balb/c mice previously vaccinated with T. rangeli. II. The innate immune response shows immunological memory: Reality or fiction?

Corynebacterium pseudotuberculosiscp09 mutant and cp40 recombinant protein partially protect mice against caseous lymphadenitis

Naegleria fowleri glycoconjugates with residues of α-d-mannose are involved in adherence of trophozoites to mouse nasal mucosa

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