Vaccinations for Adult Solid Organ Transplant Recipient: Current Recommendations

Ballout, Ahmad A; Goffin, Éric; Yombi, Jean Cyr; Vandercam, Bernard

doi:10.1016/j.transproceed.2005.05.032

Cited by 41 publications

(22 citation statements)

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“…The present authors found only four patients with influenza virus type A and one patient with influenza virus type B; the influenza epidemic during the study period was moderate compared with previous years [24]. None of the patients with CAP associated with influenza virus had been previously vaccinated, and a protective role of influenza vaccination in immunocompromised patients has been suggested [9,25].…”

Section: Discussionmentioning

confidence: 61%

Virological diagnosis in community-acquired pneumonia in immunocompromised patients

Serra

Cervera²,

Pumarola³

et al. 2007

Eur Respir J

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Community-acquired pneumonia (CAP) is a serious lower respiratory tract infection associated with significant morbidity and mortality in immunocompromised patients. The present study evaluated the clinical spectrum of CAP in immunocompromised hosts and the role of respiratory viruses, as well as the yield of viral diagnostic methods.Conventional microbiological tests were routinely performed in immunocompromised patients with CAP. Nasopharyngeal swabs were processed for respiratory viruses by indirect immunofluorescence assay, cell culture and PCR. Four groups were defined according to aetiology of CAP, as follows: group 1 (nonviral), group 2 (mixed, nonviral and viral), group 3 (only viral) and group 4 (unknown aetiology).Over a 1-yr period, 92 patients were included. An aetiological diagnosis was achieved in 61 (66%) patients: 38 (41%), group 1; 12 (13%), group 2; and 11 (12%), group 3. The most frequent pathogen detected was Streptococcus pneumoniae (n529, 48%), followed by rhinovirus (n511, 18%). PCR identified 95% of respiratory viruses. Clinical characteristics could not reliably distinguish among the different aetiological groups.Respiratory viruses represent a substantial part of the aetiologies of community-acquired pneumonia in immunocompromised patients and its routine assessment through PCR in nasopharyngeal swabs should be considered in the clinical care of these patients.

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Section: Discussionmentioning

confidence: 61%

Virological diagnosis in community-acquired pneumonia in immunocompromised patients

Serra

Cervera²,

Pumarola³

et al. 2007

Eur Respir J

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“…Despite an existing controversy regarding the safety and efficacy of influenza vaccination, annual vaccination is strongly recommended in solid organ transplant recipients (3)(4)(5). Although the general effectiveness of influenza vaccination in terms of protection from laboratory confirmed influenza is reported to be high (6)…”

Section: Introductionmentioning

confidence: 99%

Humoral and Cellular Immune Responses after Influenza Vaccination in Kidney Transplant Recipients

Candon

Thervet

Lebon

et al. 2009

American Journal of Transplantation

109

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“…Adult and pediatric organ transplant recipients appear to be more susceptible to influenza infection and its pulmonary and extrapulmonary complications, including acute cellular rejection and chronic allograft dysfunction [4]. Therefore, annual anti-influenza vaccination is recommended to adult [5] and pediatric [6] organ transplant recipients. However, there are some reservations about the efficacy of anti-influenza vaccine in the aforementioned population because of their medically induced immunosuppression.…”

Section: Introductionmentioning

confidence: 99%

Antibody Response to Influenza Immunization in Kidney Transplant Recipients Receiving either Azathioprine or Mycophenolate: A Controlled Trial

et al. 2008

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Aims: We aimed to assess humoral immune response to the influenza vaccine in adult kidney transplant recipients (KTRs) subjected to two immunosuppressive regimens containing either mycophenolate mofetil (MMF) or azathioprine (Aza). Methods: 40 eligible KTRs (24 treated with Aza [KTRs-Aza] and 16 treated with MMF [KTRs-MMF]) and 40 matched healthy controls (HCs) were administered the trivalent 2006–2007 anti-influenza vaccine. Antibody (Ab) titers were measured before (pre-vacc) and 1 month after (post-vacc) vaccination. The proportion of protective Ab titers (i.e. ≧1:40), the serological response (i.e. ≧4-fold rise in titers) rates, and the magnitudes of change in titers were evaluated. Results: KTRs and HCs were similar in serologic responses, magnitudes of change in Ab titers, and proportions of acquired protective titers against all antigens. Whereas KTRs-MMF and KTRs-Aza were identical in magnitude of rise in titers as well as in serologic responses, KTRs-MMF did poorer in developing post-vacc-protective titers against A/H1N1 (p < 0.05). The function of the transplanted kidney has not deteriorated after vaccination. Conclusions: Anti-influenza vaccination was safe in KTRs and evoked Ab responses comparable to those of HCs. KTRs-MMF and KTRs-Aza responded almost equally to the vaccine. Annual anti-influenza vaccination can be recommended to all stable KTRs.

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Vaccinations for Adult Solid Organ Transplant Recipient: Current Recommendations

Cited by 41 publications

References 0 publications

Virological diagnosis in community-acquired pneumonia in immunocompromised patients

Virological diagnosis in community-acquired pneumonia in immunocompromised patients

Humoral and Cellular Immune Responses after Influenza Vaccination in Kidney Transplant Recipients

Antibody Response to Influenza Immunization in Kidney Transplant Recipients Receiving either Azathioprine or Mycophenolate: A Controlled Trial

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