Nasal route, a subgroup of mucosal delivery systems, constitutes a lucrative and encouraging substitute for the administration of drugs and vaccines. Over the years, a lot of research has been done in this area and scientists have successfully explored this pathway using novel formulations to combat several infections. This review article aims to address the pathways of mucosal immunization, dominance of the nasal route over other mucosal routes for immunization, and mechanism of generation of immunogenic response via nasal route and nanotechnology based approaches for intranasal vaccination. The immunotherapeutic and vaccinations for intranasal administration, available in the market are also discussed along with a brief overview of the products in the pipeline. It can also be assumed that such an approach can prove to be favorable in the designing of vaccinations for the current uncertain times. In spite of some dubious views on this.