In 2022, around 54 % of African students were denied student visas to study in the United States (US), compared to 36 % of Asian students and 9 % of European students, despite African immigrants in the US often being more highly educated than the US native-born population. This issue cannot be attributed solely to the dichotomy between the Global North and South in visa regimes, but it is also evident among African nations across regional economic blocs. The African BioGenome Project (AfricaBP) Open Institute for Genomics and Bioinformatics, which aims to overcome barriers to capacity building through its distributed African regional workshops, prioritizes grassroots knowledge exchange and innovation in biodiversity genomics and bioinformatics. In 2023, we orchestrated the implementation of 27 capacity building workshops on biodiversity genomics and bioinformatics, covering 10 African countries across 5 African geographical regions. The AfricaBP Open Institute regional workshops raised awareness of biodiversity genomics and bioinformatics among 3788 registered participants, and trained 408 African scientists in hands-on molecular biology, genomics, and bioinformatics techniques. Here, we discuss the implementation of transformative strategies by deploying the AfricaBP Open Institute multi-country, multi-institution, and multi-partner hybrid regional workshop model, including the proposed creation of an African digital database containing sequence information relating to biodiversity and agriculture.