Vaccine after Effects and Post-Vaccine Infection in a Real World Setting: Results from the COVID Symptom Study App

Menni, Cristina; Kläser, Kerstin; May, Anna; Polidori, Lorenzo; Capdevila, Joan; Louca, Panayiotis; Sudre-Ferraris, Carole; Nguyen, Long H.; Da, Drew; Merino, Jordi; Antonelli, Michela; Murray, Benjamin; Ls, Canas; Molteni, Erika; Ms, Graham; Modat, Marc; Ad, Joshi; Mangino, Massimo; Hammers, Alexander; Td, Spector; Am, Valdes; Al, Goodman; At, Chan; Wolf, Jonathan; Steves, Claire J.; Ourselin, Sébastien; Spector, Timothy D.

doi:10.2139/ssrn.3795344

Cited by 6 publications

(8 citation statements)

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“…Other studies reported less adverse events in males and those aged over 55 years [34][38] [39] CONCLUSION and RECOMMENDATION Side effects from vaccination are common and indicate that the immune system is reacting.…”

Section: Discussionmentioning

confidence: 99%

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Covid-19 Vaccines Side Effects in Iraq

Zangana¹,

Ali²

2022

KJMS

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 Background: The "Severe Acute Respiratory Syndrome Coronavirus 2" (SARS-CoV-2) disease has resulted in a worldwide challenging and dangerous pandemic, COVID-19 vaccines have been preventing serious morbidities and mortality associated with the infection. However, in addition to these findings, some unusual adverse effects have been reported. Vaccine side effects are common. They demonstrate that immunizations are effective, and that the immune system is responding. For assessing the safety of the vaccine, side effects and adverse events are fundamental.  Objective: To evaluate side effects of corona virus vaccines.  Method: A prospective cohort study using a pre-organized questionnaire encompassing, demographic, general health, the status of SARS-CoV-2 infection, vaccination, associated adverse events, breakthrough infections and their IgG antispike antibody titers; in a population comprising 200 individuals aged 18 and above who received 2 doses of one of covid-19 vaccines.  Results: The responses of 200 individuals were analyzed statistically. Revealing that most utilized vaccine in the population was the Pfeizer-BioNtech vaccine. Side effects were generally subtle, in all three vaccines, with no serious adeverse events. Oxford-AstraZeneca vaccine however, showed fiercer side effects compared to the other two vaccines. Several side effects were more prevalent in male gender, but there was no noteworthy correlation with other factors.  Conclusion: COVID-19 vaccinations appear to be safe. Although adverse events are rare on a worldwide scale, a large proportion of the world's population will be exposed to these vaccines. for this reason, their safety and tolerance must be carefully evaluated. More research is needed, however, to investigate the vaccines' long-term efficacy and safety, as well as the effect of dose, age, and general health condition on protective efficacy.

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Section: Discussionmentioning

confidence: 99%

“…In our study, the duration of side effects experienced after vaccination showed no correlation with the level of anti-spike IgG antibody titer. Clinical trials on Pfizer BioNTech (BNT162) revealed that, despite 90% of recipients establishing protectionto the virus, although 50% of vaccine recipients did not experience any side effects [34].…”

Section: Discussionmentioning

confidence: 99%

Covid-19 Vaccines Side Effects in Iraq

Zangana¹,

Ali²

2022

KJMS

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“…15 Similarly, Menni et al reported that those vaccinated with the ChAdOx1 nCoV-19 vaccine were more likely to experience systemic side effects than those who had been given other types. 17 Several viral vaccine development platforms include live attenuated, inactivated, DNA-based, RNA-based, proteinbased, and viral vector-based.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of adverse effects of COVID19 vaccines among a sample of Iranian healthcare workers; a comparison between the three available vaccines in Iran

Mousavi,

Tehranchi,

Namdari

et al. 2021

J. Contemp. Med. Sci.

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Objectives:Describing what to expect after the first and second dose of vaccination will increase the public confidence. This study aimed to describe the short-term side effects after receiving the first, the second, or both doses of Sputnik V, Oxford-AstraZeneca, and Sinopharm vaccines in personnel and students of shahid Beheshti dentistry school. Methods: A cohort project has been conducting at the dental faculty since June 2020. This article is a cross-sectional study as a section of the cohort project. Dental faculty began its campaign to vaccinate the personnel on April 2021, with the Sputnik V and Oxford-AstraZeneca and Sinopharm. An employed operator phoned each one by one after 48 hours of vaccination. She asked them about any experienced symptoms after receiving each dose. The reported symptoms were coded and categorized. Results: The most common symptoms in AstraZeneca's first dose were fever followed by Myalgia. After the second dose, the frequency of all symptoms had been reduced significantly. After the first dose of Sputnik V, the most common symptoms were Myalgia followed by fever. The frequency of fever and pain at the injection site increased significantly after the second dose (P < 0.001). In the Sinopharm group, all symptoms occurred whit a low percentage. The most common symptoms were again, Myalgia and pain at the injection site. Conclusion: Post-vaccination adverse effects were mild in all groups and controlled by analgesic. Fever, myalgia and pain at the injection site are the most common symptoms reported after vaccination by all three types of vaccines.

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“…For COVID-19, vaccines are safe and effective in higher-risk groups, including older adults and the immunocompromised, 59 and significantly reduce the risk of severe illness even when vaccinated groups are exposed to substantial community transmission. 60 While there are some people for whom the current COVID-19 vaccines are contraindicated (e.g., those with severe allergies), this group appears to be small. 61 It is therefore not the case that vulnerable groups cannot protect themselves, which would make routine vaccination of less vulnerable groups-children, in this case-more compelling.…”

Section: Objection 4: Vulnerable Groups Can Protect Themselves and Cu...mentioning

confidence: 99%

Against COVID‐19 vaccination of healthy children

2022

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COVID‐19 vaccination of children has begun in a number of countries with provisional regulatory approval and public support. This article provides an ethical analysis of COVID‐19 vaccination of healthy children. Specifically, we present three of the strongest arguments that might justify COVID‐19 vaccination of children: (a) an argument from paternalism, (b) an argument from indirect protection and altruism, and (c) an argument from global eradication. We offer a series of objections to each of these arguments to show that none of them is currently tenable. Given the minimal direct benefit of COVID‐19 vaccination for healthy children, the potential for rare risks to outweigh these benefits and to undermine vaccine confidence, the substantial evidence that COVID‐19 vaccination confers adequate protection to risk groups whether or not healthy children are vaccinated and that current vaccines do not provide sterilizing immunity, and given that eradication of the virus is neither feasible nor a high priority for global health, we argue that routine COVID‐19 vaccination of healthy children is currently ethically unjustified. Since mandates for children have already been implemented in some places (e.g., California) and may be considered elsewhere, we also present two additional arguments explicitly against making COVID‐19 vaccination mandatory for children.

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Vaccine after Effects and Post-Vaccine Infection in a Real World Setting: Results from the COVID Symptom Study App

Cited by 6 publications

References 0 publications

Covid-19 Vaccines Side Effects in Iraq

Covid-19 Vaccines Side Effects in Iraq

Prevalence of adverse effects of COVID19 vaccines among a sample of Iranian healthcare workers; a comparison between the three available vaccines in Iran

Against COVID‐19 vaccination of healthy children

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