Vaccine contamination: Causes and control

Chooi, Wen Han; Ng, Pit Wei; Hussain, Zahid; Ming, Long Chiau; Ibrahim, Baharudin; Koh, David

doi:10.1016/j.vaccine.2022.02.034

Cited by 6 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical trials and regulatory procedures for oral vaccines may incur lower costs, due to their less complex administration process. The manufacturing costs of oral vaccines are generally lower than those of injectable vaccines, as injectable vaccines typically require more complex production processes, including the purification and formulation of the vaccine antigens [ 111 ]. However, it is essential to remember that the actual cost of each type of vaccine is subject to the design of the vaccine and its clinical trial programs.…”

Section: Regulatory Procedures and Clinical Trials For Injectable Vac...mentioning

confidence: 99%

Oral Vaccines: A Better Future of Immunization

Kwong¹,

Xin²,

Lai³

et al. 2023

Vaccines

View full text Add to dashboard Cite

Oral vaccines are gaining more attention due to their ease of administration, lower invasiveness, generally greater safety, and lower cost than injectable vaccines. This review introduces certified oral vaccines for adenovirus, recombinant protein-based, and transgenic plant-based oral vaccines, and their mechanisms for inducing an immune response. Procedures for regulatory approval and clinical trials of injectable and oral vaccines are also covered. Challenges such as instability and reduced efficacy in low-income countries associated with oral vaccines are discussed, as well as recent developments, such as Bacillus-subtilis-based and nanoparticle-based delivery systems that have the potential to improve the effectiveness of oral vaccines.

show abstract

Section: Regulatory Procedures and Clinical Trials For Injectable Vac...mentioning

confidence: 99%

Oral Vaccines: A Better Future of Immunization

Kwong¹,

Xin²,

Lai³

et al. 2023

Vaccines

View full text Add to dashboard Cite

show abstract

“…However, like most medical products, vaccines have the risk of side effects [ 4 ]. Even if a vaccine is well produced, there may be design, manufacturing, or distribution flaws [ 5 , 6 ]. As an example, there were 98 verified cases of intussusception following rotavirus vaccine immunisation reported to the Vaccine Adverse Event Reporting System of the United States, with 60 developing intussusceptions within one week after vaccination [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

A solution towards a viable compensation mechanism for injury from COVID-19 vaccines in Malaysia: A qualitative study

Mokhtar,

Ariff,

Manap

et al. 2024

Heliyon

View full text Add to dashboard Cite

Microbial Dynamics and Quality Monitoring in Biopharmaceutical Production

Pashang,

Gilbride,

Wenk

2024

ChemBioEng Reviews

View full text Add to dashboard Cite

Prokaryotic cells are pivotal in meeting the global demand for biopharmaceuticals. However, challenges such as the absence of advanced technology for real‐time monitoring, standardized testing methodologies, and quality risk assessment of microbial activity have led to increased production costs, delays, and shortages of biopharmaceutical products. A thorough understanding of how biomolecule production interacts with microbial population structure and function is vital for improving continuous manufacturing and process automation. In this review, we discuss the current microbiological techniques that meet good manufacturing practice requirements in industrial settings, explore the advantages of monitoring and measuring biomass growth efficiency and turnover rates beyond regulatory criteria for product release, and provide a critical assessment of the current state of knowledge on bioassays and engineering tools for biomolecule yield measurement and monitoring. Furthermore, we identify areas for future development, potential applications, and the need for interdisciplinary innovation to drive future research, including advancing bioassays for biopharmaceutical wastewater risk.

show abstract

Vaccine contamination: Causes and control

Cited by 6 publications

References 8 publications

Oral Vaccines: A Better Future of Immunization

Oral Vaccines: A Better Future of Immunization

A solution towards a viable compensation mechanism for injury from COVID-19 vaccines in Malaysia: A qualitative study

Microbial Dynamics and Quality Monitoring in Biopharmaceutical Production

Contact Info

Product

Resources

About