Vaccine-derived poliovirus serotype 2 outbreaks and response in the Democratic Republic of the Congo, 2017–2021

Alleman, Mary; Jorba, Jaume; Yogolelo, Riziki; Henderson, Elizabeth; Mwehu, Anicet; Seakamela, Lerato; Howard, Wayne; Mbule, A.; Nsamba, Renee Ntumbannji; Djawe, Kpandja; Yapi, Moïse Désiré; Mengouo, Marcellin Nimpa; Gumede, Nicksy; Ndoutabe, Modjirom; Kfutwah, Anfumbom K.W.; Senouci, Kamel; Burns, Cara C.

doi:10.1016/j.vaccine.2023.02.042

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…Nationally representative surveys estimated that Haut Lomami and Tanganyika had less than 50 % full immunization coverage; Multiple Indicator Cluster Studies (MICS) in 2017–18 estimated 35.7 % full immunization coverage in Haut Lomami and 21.2 % full immunization coverage in Tanganyika, with more than 10 % zero-dose children, and child mortality greater than 40 per 1000 live births [2] . By mid-2018, both Tanganyika and Haut Lomami continued to report cases of cVDPV2, despite multiple rounds of supplemental immunization activities (SIAs) with the monovalent oral polio vaccine (mOPV) [3] . Persistent outbreaks and low vaccination coverage highlighted the need to improve the quality of the outbreak responses and bolster the existing vaccine-delivery system [4] , [5] .…”

Section: Introductionmentioning

confidence: 99%

Strengthening immunization programs through innovative sub-national public-private partnerships in selected provinces in the Democratic Republic of the Congo

Banza Mpiongo,

Kibanza,

Kambol Yav

et al. 2023

Vaccine

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Section: Introductionmentioning

confidence: 99%

Strengthening immunization programs through innovative sub-national public-private partnerships in selected provinces in the Democratic Republic of the Congo

Banza Mpiongo,

Kibanza,

Kambol Yav

et al. 2023

Vaccine

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“… 11 Since August 2020, WHO certified the African Region free from all three types of wild poliovirus (WPV) when Nigeria became the last African country to interrupt wild poliovirus transmission. 12 The DRC has been certified polio-free since 2012, however, since 2004, it has documented continued transmission 13 circulating derived poliovirus type 2 (cVDPV2) and type 1 (cVDPV1) cases. 14 , 15 Since May 2017, there has been an ongoing outbreak of VDPVs in the DRC.…”

Section: Introductionmentioning

confidence: 99%

Prediction Model with Validation for Polioseronegativity in Malnourished Children from Poliomyelitis Transmission High-Risk Area of the Democratic Republic of the Congo (DRC)

Mwamba,

Kabamba,

Hoff

et al. 2023

POR

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Background Malnutrition is identified as a risk factor for insufficient polio seroconversion in the context of a vaccine-derived poliovirus (VDPV) outbreak-prone region. In the Democratic Republic of Congo (DRC), underweight decreased from 31% (in 2001) to 26% (in 2018). Since 2004, VDPV serotype 2 outbreaks (cVDPV2) have been documented and were geographically limited around the Haut-Lomami and Tanganyika Provinces. Methods To develop and validate a predictive model for poliomyelitis vaccine response in malnourished infants, a cross-sectional household study was carried out in the Haut-Lomami and Tanganyika provinces. Healthy children aged 6 to 59 months (n=968) were enrolled from eight health zones (HZ) out of 27, in March 2018. We performed a bivariate and multivariate logistics analysis. Final models were selected using a stepwise Wald method, and variables were selected based on the criterion p < 0.05. The association between nutritional variables, explaining polio seronegativity for the three serotypes, was assessed using the receiver operating characteristic curve (ROC curve). Results Factors significantly associated with seronegativity to the three polio serotypes were underweight, non-administration of vitamin A, and the age group of 12 to 59 months. The sensitivity was 10.5%, and its specificity was 96.4% while the positive predictive values (PPV) and negative (PNV) were 62.7% and 65.3%, respectively. We found a convergence of the curves of the initial sample and two split samples. Based on the comparison of the overlapping confidence intervals of the ROC curve, we concluded that our prediction model is valid. Conclusion This study proposed the first tool which variables are easy to collect by any health worker in charge of vaccination or in charge of nutrition. It will bring on top, the collaboration between the Immunization and the Nutritional programs in DRC integration policy, and its replicability in other low- and middle-income countries with endemic poliovirus.

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Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences

Oduoye,

Ubechu,

Mourid

et al. 2024

New Microbes and New Infections

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Vaccine-derived poliovirus serotype 2 outbreaks and response in the Democratic Republic of the Congo, 2017–2021

Cited by 3 publications

References 16 publications

Strengthening immunization programs through innovative sub-national public-private partnerships in selected provinces in the Democratic Republic of the Congo

Strengthening immunization programs through innovative sub-national public-private partnerships in selected provinces in the Democratic Republic of the Congo

Prediction Model with Validation for Polioseronegativity in Malnourished Children from Poliomyelitis Transmission High-Risk Area of the Democratic Republic of the Congo (DRC)

Re-emergence of vaccine-derived polio in the demographic Republic of Congo: Causes and consequences

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