Vaccine hesitancy prospectively predicts nocebo side-effects following COVID-19 vaccination

Levin, Yafit; Palgi, Yuval; Ben–Ezra, Menachem; Greenblatt‐Kimron, Lee

doi:10.1038/s41598-022-21434-7

Cited by 10 publications

(3 citation statements)

References 46 publications

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“…While nocebo effects are driven more by misinformation (verbal manipulation) in males, they are found to be driven by conditioning and previous experience in females [ 58 ]. This lagged effect is further documented by Hoffman and colleagues [ 59 ], who reported that COVID-19 vaccine side effects decreased across waves for males but increased for females. Accordingly, the association between wave one and wave two side effects (wave one following a second Pfizer dose, wave two after their booster) was more robust in females.…”

Section: Discussionsupporting

confidence: 61%

Follow-Up of Side Effects throughout the Entire Course of Coronavirus Vaccination

et al. 2023

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Vaccines are considered the best protective means against coronavirus infection. There is increasing interest in reporting the side effects of vaccines, especially for individuals younger than 18 years old. Accordingly, this analytical cohort study aims to report on the side effects of adult and young individuals who received vaccination within 24 h, 72 h, 5 days, and 1 week through the entire course of vaccination (ECoV). A validated online survey was used to collect information. In total, 1069 individuals were completely followed. Most individuals received the Pfizer vaccine (59.6%). Most individuals had received two doses (69.4%). Very strong and statistically significant associations with side effects (p < 0.05, Phi (Φ) > 0.25) throughout the ECoV were reported for the type of vaccine and female gender. Non-smokers reported weak statistically significant associations. Fatigue and localized pain were the most commonly reported side effect, with onset within 24 h and duration of less than 72 h. The prevalence of reported side effects was statistically significantly higher among young individuals (<18 years old) than among adults (X2 (1) =7.6, p = 0.006. Phi φ = 0.11).

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Section: Discussionsupporting

confidence: 61%

Follow-Up of Side Effects throughout the Entire Course of Coronavirus Vaccination

et al. 2023

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“…Available literature however accuses vector-based vaccines to be more frequently associated with (severe) neurological side effects [ 7 , 20 ]. On the other hand, mRNA-COVID‐19 vaccine side‐effects have been attributed to a nocebo component in association with vaccine hesitancy [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Neurological symptoms after COVID-19 vaccination: a report on the clinical presentation of the first 50 patients

Gerhard,

Raeder,

Pernice

et al. 2023

J Neurol

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Objectives Neurological symptoms associated with Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) vaccination were discovered in the context of billions of administered vaccine doses. The clinical manifestations often resemble post Coronavirus Disease 2019 (post-COVID-19) syndrome (PCS) features and may be considered as post-COVID-19 vaccine syndrome (PVS). Data regarding frequency, severity and pathophysiological mechanisms are scarce. Methods We assessed routine clinical examinations in 50 patients reporting new-onset neurological symptoms after SARS-CoV-2 vaccination, including neurological examination, laboratory and electrophysiology tests, as well as self-report questionnaires measuring fatigue, depressive symptoms, anxiety, risk of somatic symptom disorder, and health-related quality of life. Patients were included when symptoms occurred after confirmed COVID-19 vaccination and without prior SARS-CoV-2 infection, and if no alternative diagnosis was found to explain the symptoms. Results The most frequently reported symptoms were paraesthesia (56%), fatigue (46%) and cognitive impairment (36%). Neurological, routine laboratory, and electrophysiological examinations did not yield distinct pathological findings. Neuropsychological testing of a subgroup revealed deficits in attention, executive function and memory. Discussion The spectrum of clinical manifestations post-vaccination poses a substantial overlap with PCS symptoms. As no pathological findings were obtained in routine diagnostics, uncertainty remains about the underlying pathophysiological mechanisms and requires further investigation beyond routine work-up.

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“…Some adverse reactions after vaccination possibly comprise a psychosomatic nocebo component that has been very poorly studied in individuals vaccinated against SARS-CoV-2 [ 14 ]. A study by Zhu et al showed that, after receiving a physiological solution, 37% of participants in the placebo group reported adverse events.…”

Section: Introductionmentioning

confidence: 99%

The Impact of the Emotional Disposition of Healthcare Workers on the Expression of Adverse Events after Primary Vaccination against SARS-CoV-2

Sauserienė,

Serapinas,

Liseckienė

et al. 2024

Medicina

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Background and Objectives: Vaccination is one means of SARS-CoV-2 prevention and control. However, despite the effectiveness of vaccination, adverse reactions continue to require vigilance and monitoring. The researchers emphasize the possibility that some of the reported side effects may be psychological in origin. Based on this hypothesis, the main goal of this study was to evaluate the emotional dispositions of healthcare workers who experienced emotions before vaccination and adverse reactions after vaccination. Materials and Methods: This study was conducted between February and May 2021 in the Kaunas Clinics of the University of Health Sciences. A total of 2117 employees of the clinic departments who were vaccinated with two doses of the Pfizer–BioNTech vaccine participated in this study. Statistical analysis was performed on the data using IBM SPSS Statistics®. Results: Most participants (74.5%) experienced systemic (including local) adverse events; 16.5% experienced only local adverse events, and 9.1% experienced no adverse events. The frequency of systemic (including local) adverse events reduced with increasing age (p < 0.05). The main emotions that participants experienced before vaccination were anxiety (37.88%) and happiness (39.02%). Systemic (including local) adverse events occurred 1.26 times more frequently in women than men (77.44% vs. 61.6%, p < 0.05), while local adverse events occurred 1.4 times more often in male participants than in female participants (21.39% vs. 15.27%, p < 0.05). Among the respondents who did not experience adverse events, the most common emotion felt was happiness (25.5%), and most of the participants who experienced systemic (including local) adverse events felt anxiety (42.6%). Conclusions: The information about vaccination and potential adverse events should be targeted at younger persons. It is recommended that women, more than men, should receive professional counseling from psychologists or psychotherapists. The public dissemination of positive messages about the benefits and safety of vaccines prior to a vaccination campaign may alleviate the tension or anxiety felt regarding potential adverse events. Healthcare specialists—both those who work directly with vaccines and those who do not—should maintain a positive psychological attitude towards vaccination, as this can increase patient satisfaction with the benefits of vaccines.

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Vaccine hesitancy prospectively predicts nocebo side-effects following COVID-19 vaccination

Cited by 10 publications

References 46 publications

Follow-Up of Side Effects throughout the Entire Course of Coronavirus Vaccination

Follow-Up of Side Effects throughout the Entire Course of Coronavirus Vaccination

Neurological symptoms after COVID-19 vaccination: a report on the clinical presentation of the first 50 patients

The Impact of the Emotional Disposition of Healthcare Workers on the Expression of Adverse Events after Primary Vaccination against SARS-CoV-2

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