Vaccine-Induced Anti-HBs Level in 5-6 Year-Old Malnourished Children

Karimi, Mehran; Raee, Ali; Baghianimoghadam, Behnam; Fallahzadeh, Hossein

doi:10.5812/hepatmon.7048

Cited by 12 publications

(8 citation statements)

References 33 publications

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“…For instance, Rey et al (41) found that nutritional status was significantly associated with response to HBV vaccination in Senegal and Cameroon, where 85% of children with normal nutritional status were protected (anti-HBs ≥10 IU/L) versus 60% with moderate to severe malnutrition. In Iran, Karimi et al (42) found a significant decrease in the immune response to HBV vaccine in malnourished children (60.2%) and that severe acute malnutrition produced a higher protective immune response than moderate acute malnutrition. Losonsky et al (43) concluded that low and poor weight gains in the first 6 months of life were associated with reduced immunogenicity (71%) following three doses of HBV vaccine in the United States.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Immune Response to Hepatitis B Vaccine among Malnourished Children in Yemen

Alsamei¹,

Elagib²,

Al-Sonboli³

et al. 2015

YEM J SCI

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Objectives: To determine the coverage rate of hepatitis B virus (HBV) vaccine and to evaluate the immune response to HBV vaccine by measuring hepatitis B surface antibody (anti-HBs) among malnourished under-five-year old children. Methods: A cross-sectional study was conducted in two tertiary hospitals in Yemen; Al-Sabeen Maternity and Child Hospital in Sana'a and the Yemeni-Swedish Hospital in Taiz city in the period from March 2014 to Dec. 2014. The target population was malnourished children aged from 6 to 59 months old with a history of three HBV vaccine doses in infancy. According to the World Health Organization's definition of malnutrition, 121 malnourished children were enrolled in the study. Data of malnourished children were collected using a pre-designed, pre-tested questionnaire. Two milliliters of venous blood were taken, and anti-HBs was then tested by enzyme linked immunosorbent assay. An anti-HBs level of at least 10 IU/L was considered a successful response to the vaccine. Results: The coverage rate of HBV vaccine among malnourished children was 89.3%, being higher among girls (52.1%) than boys (37.2%). Response to HBV vaccine (≥10 IU/L) was observed in 72.2% (78/108) of children while 27.8% (30/108) of children failed to respond to the vaccine, with a statistically significant difference (p <0.001). Conclusions: A good HBV vaccine coverage rate was found among malnourished Yemeni children, with a moderate rate of protection. Therefore, re-vaccination or administration of booster doses to a substantial proportion of vaccinated children should be considered.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Immune Response to Hepatitis B Vaccine among Malnourished Children in Yemen

Alsamei¹,

Elagib²,

Al-Sonboli³

et al. 2015

YEM J SCI

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“…Viral hepatitis B is one of the most serious public health problems worldwide ( 1 ). There are more than two billion people infected in the world, of whom about 400 million are chronic carriers ( 2 ) and approximately 1 million people die annually because of the disease ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

“…Vaccination represents the main instrument to prevent HBV infection ( 1 , 13). Immunization should be carried out in three doses, with a month interval between the first and second dose and of six months between the first and the third dose, in order to stimulate the production of antibodies anti-HBs ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Hepatitis B: Knowledge, Vaccine Situation and Seroconversion of Dentistry Students of a Public University

et al. 2013

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BackgroundViral hepatitis B (VHB) is an occupational risk for dentists. It is necessary that dental students start clinical practice immunized with the vaccine, response monitored and informed about the means of transmission of the disease. Rarely, there are studies, which evaluate concomitantly knowledge of these academics and their vaccine situation.ObjectivesTo evaluate the knowledge about Hepatitis B, the vaccine situation and the immunization status of dental students and to investigate the probable correlation between the status of immunization, vaccination membership and adherence to the test of seroconversion and associated factors.Patients and Methods189 students from the dentistry course at the Federal University of Piaui (UFPI) who attended from the 3rd to 9th period were invited to participate in the research. Their knowledge about HBV, attitude regarding protection and their vaccine situation were assessed through a self-administered form. Antibodies against surface antigens of Hepatitis B virus (Anti-HBs) and against the antigens of the virus nucleous of Hepatitis B (Anti-HBc total) were measured qualitatively using the enzyme-linked immunosorbent assay (ELISA).ResultsOf the 179 students surveyed, 58.1% knew about the degree of virulence of the Hepatitis B virus (HBV). As to the means of transmission, 98.3% considered blood transmission, 82.6% plates and cutlery, 15.6% cough and 12.3% vertical transmission. Most students (87.4%) knew that they should take 3 doses of the vaccine and 62.2% completed the immunization schedule. A minority of students (48.6%) knew the about the Anti-HBs test and 5.6% took the test. Among the students who reported having taken three doses of the vaccine, 12.5% were not seroconverted. There was no significant correlation between the variables.ConclusionsDental academics were unsure about the means of infection and prevention against HBV. Many of them had not completed the immunization scheme and did not have the test of seroconversion. The serological analysis revealed unprotection, even after students completed the vaccination schedule.

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“…el-Gamal Y et al 18reported that seroconvertion rate was lower in children with protein calorie malnutrition than healthy children (87% vs 100%, respectively). In contrast with these reports, Karimi et al (19) and Karaoglu et al(13) reported that severity of malnutrition does not affect vaccine-induced antibody level and seroprotection rate. No correlation was found between response rate and mid-upper arm circumference, but anti-HBsAg titers were significantly lower in children who had lower mid-upper arm circumference.…”

Section: Discussionmentioning

confidence: 80%

Hepatitis B Vaccination and Factors Related with Unresponsiveness in Healthy Children

Urgancı¹,

Kalyoncu²,

As³

2015

West Indian Med J

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Background: The aim of this study was to assess the effectiveness of HBV vaccination and factors associated with vaccine unresponsiveness in healthy children. Methods: A total of 141 healthy children aged between 2-5 years were included in the study. All of the cases had received 20 µg of recombinant DNA vaccine for hepatitis B (0,1 and 6 months). Demographic features and the factors such as duration of breastfeeding, exposure to HBsAg-positive family members, administration of concomitant vaccines and exposure to smoke were determined. HBV serological markers were evaluated. Postvaccination serologic evaluation was performed one month after the last dose of primary vaccination, one month after the booster dose. HLA typing was performed in nonresponders. Results: 87.9% of the children achieved seroprotection (anti-HBs titres ≥10 mIU/ml) one month after primary vaccination. No difference was observed between vaccine responsiveness and age, sex, birth weight, maturity, duration of breastfeeding, exposure to HBsAg-positive family members and mid-upper arm circumference (P>0.05). A significant correlation was obtained between anti-HBsAg titers and midupper arm circumference (P=0.005). HLA types, DRB 111 (64.7%), B5 (52.9%), DRB 104 (52.9%) and DRB 11001 (47%) were detected at increased frequency in nonresponders. Conlusions: The antibody titers were significantly higher in children who breastfed for the first 6 months and longer and who were vaccinated concomitantly with other common vaccines.

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Vaccine-Induced Anti-HBs Level in 5-6 Year-Old Malnourished Children

Cited by 12 publications

References 33 publications

Evaluation of Immune Response to Hepatitis B Vaccine among Malnourished Children in Yemen

Evaluation of Immune Response to Hepatitis B Vaccine among Malnourished Children in Yemen

Hepatitis B: Knowledge, Vaccine Situation and Seroconversion of Dentistry Students of a Public University

Hepatitis B Vaccination and Factors Related with Unresponsiveness in Healthy Children

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