2011
DOI: 10.1016/j.vaccine.2011.02.010
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Vaccine-induced anti-tuberculosis protective immunity in mice correlates with the magnitude and quality of multifunctional CD4 T cells

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Cited by 127 publications
(122 citation statements)
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“…It is important that the RSQ-15 DNA vaccine drove a high reservoir of effector antigen-specific T cell responses as we observed, as such responses are likely important in pathogen control and clearance. 44 Moreover, we observed that the most immunodominant T cell responses induced by RSQ-15 were esxQ, esxS, esxR, and esxH. In agreement with previous studies, we find esxH to be highly immunogenic.…”
Section: Discussionsupporting
confidence: 91%
See 1 more Smart Citation
“…It is important that the RSQ-15 DNA vaccine drove a high reservoir of effector antigen-specific T cell responses as we observed, as such responses are likely important in pathogen control and clearance. 44 Moreover, we observed that the most immunodominant T cell responses induced by RSQ-15 were esxQ, esxS, esxR, and esxH. In agreement with previous studies, we find esxH to be highly immunogenic.…”
Section: Discussionsupporting
confidence: 91%
“…29,30,44,[51][52][53] These data highlight the importance of a vaccine that can induce optimal activation of both CD8 and CD4 T cells which could be the cornerstone for protective immunity against TB. In these studies we observe that compared with naïve animals and the BCG vaccine group, the RSQ15 vaccine induced relatively high levels of multifunctional CD4 T cells expressing dual IFN-γ and TNF-α after immunization, while esxV, esxU, esxS, esxQ, esxH, and esxR induced potent CD8 T cells secreting dual IFN-γ/TNF-α.…”
Section: Discussionmentioning
confidence: 99%
“…These foreskin responses were robust in magnitude and durable for at least 1 year after immunization. Similar to our previous observations with gastrointestinal and cervicovaginal mucosa (13), the Ad35/Ad26 vaccine-elicited SIV-specific CD4 ϩ and CD8 ϩ T cells in foreskin were primarily TM and EM phenotype capable of secreting both IFN-␥ and TNF-␣, suggesting that they may be poised for rapid and potent responses against virus challenges (13,20,21). However, it remains unclear to what extent the observed vaccine-elicited SIV-specific immune responses protect against SIV infection through foreskin.…”
Section: Discussionsupporting
confidence: 87%
“…In addition, the number of polyfunctional memory CD4 + and CD8 + T cells producing double cytokines, IFN-g plus IL-2, in the lung was 6-to 10-fold greater in frequency than that in peripheral blood, suggesting a possible functional difference between memory T cells from the two compartments. Increase in the number of polyfunctional T cells that produce multiple cytokines is known to associate with protective immunity in many infection models (41)(42)(43)(44).…”
Section: Discussionmentioning
confidence: 99%