Vaccine‐induced pityriasis rosea and pityriasis rosea‐like eruptions: a review of the literature

Drago, Francesco; Ciccarese, Giulia; Javor, Sanja; Parodi, Aurora

doi:10.1111/jdv.12942

Cited by 52 publications

(77 citation statements)

References 7 publications

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“…Many drugs may induce a PR-like eruption, including barbiturates, methopromazine, captopril, clonidine, gold, metronidazole, D -penicillamine, isotretinoin, levamisole, Pyribenzamine, nonsteroidal anti-inflammatory agents, omeprazole, terbinafine, ergotamine tartrate, tyrosine kinase inhibitors, and biological agents (adalimumab) [5]. PR-like rashes have also been reported after vaccinations for diphtheria, smallpox, pneumococcal, hepatitis B virus, BCG, and human papillomavirus [5,34]. From a practical viewpoint, to distinguish between PR and PR-like eruptions, and of course whether and when it is necessary to stop the involved drug, is of paramount importance since a typical PR may develop during but independently from a therapy.…”

Section: Pr Classificationmentioning

confidence: 99%

Pityriasis Rosea: A Comprehensive Classification

et al. 2016

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Pityriasis rosea (PR) is an acute, self-limiting exanthematous disease associated with the endogenous systemic reactivation of human herpesvirus (HHV)-6 and/or HHV-7. The disease typically begins with a single, erythematous plaque followed by a secondary eruption with lesions on the cleavage lines of the trunk (configuration of a ‘Christmas tree'). The duration may vary from 2 weeks to a few months. Besides the typical presentation of PR, atypical forms have been described. The previous classifications of PR are mainly based on its atypical morphological features rather than on the pathogenetic mechanisms that underlie the different presentations of the disease. Notably, most of the morphologically atypical forms follow a course amenable to the classic form. The classification that we propose, taking into account the pathogenesis, clinical features, and course of the disease, is easy and intuitive and may be helpful in identifying the atypical forms of PR in order to avoid misdiagnosis and establish the best treatment options. Finally, this classification provides indications for managing potentially harmful forms of PR (such as PR in pregnancy) and PR-like eruptions.

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Section: Pr Classificationmentioning

confidence: 99%

Pityriasis Rosea: A Comprehensive Classification

et al. 2016

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“…Secondly, we would like to emphasize that not only drugs, as stated by Gupta and Levitt [1], but also many types of vaccinations may induce PR and PRlike eruptions, as recently reported [9]. Regarding post vaccination PR, it has been hypothesized that the vaccine, eliciting a specific immune response against a definite infectious agent, may disrupt the T-cell-mediated control on the latent infections, such as HHV-6/7, which may reactivate.…”

mentioning

confidence: 79%

Atypical presentations of pityriasis rosea: a reply

Ciccarese

Drago²

2017

Dermatology Online Journal

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“…In addition to the typical presentation, some variants of PR have been described, such as persistent PR, relapsing PR, PR in pregnancy and paediatric PR . In addition, a number of drugs can induce PR‐like eruptions …”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5] In addition, a number of drugs can induce PR-like eruptions. 6 To date, the aetiology and pathogenesis of PR remain elusive. The viral hypothesis is currently the most credited, in particular human herpes viruse (HHV)-6 and HHV-7.…”

Section: Introductionmentioning

confidence: 99%