Vaccine-induced seroconversion in participants in the North Carolina COVID-19 community Research Partnership

Friedman-Klabanoff, DeAnna; Tjaden, Ashley H.; Santacatterina, Michele; Munawar, Iqra; Sanders, John W.; Herrington, David M.; Wierzba, Thomas F.; Berry, Andrea A.

doi:10.1016/j.vaccine.2022.09.021

Cited by 8 publications

(10 citation statements)

References 12 publications

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“…Since the early phase of the COVID-19 pandemic, a number of measures have been applied and practiced in attempts to restrain and contain the spread of the COVID-19 infection; these include social distancing, hand washing, face-mask wearing, border shutdowns, quarantine, and travel restrictions, among others [ [7] , [8] , [9] , [10] , [11] ]. As part of the ongoing measures to restrict the spread of the COVID-19 pandemic, vaccination played a crucial role in curbing and resolving the COVID-19 pandemic [ [12] , [13] , [14] ].…”

Section: Introductionmentioning

confidence: 99%

Utilizing the theory of planned behavior to predict COVID-19 vaccination intention: A structural equational modeling approach

Bui

Duong

Nguyen

et al. 2023

Heliyon

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Section: Introductionmentioning

confidence: 99%

Utilizing the theory of planned behavior to predict COVID-19 vaccination intention: A structural equational modeling approach

Bui

Duong

Nguyen

et al. 2023

Heliyon

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“…The impact of this study is amplified because cohort studies of highly vaccinated adults without pre-exis;ng severe health problems who were not hospitalized for COVID-19 are scarce [40,41] and because few COVID-19 studies have reported longitudinal data from sampling of the same individuals over a long period [42].…”

Section: Discussionmentioning

confidence: 99%

“…This 1.5-year longitudinal study of the humoral response elicited by vaccination and by SARS-CoV-2 infection in a cohort of 304 essential workers from food service and retail in the Québec City area continues to highlight the capacity for a decentralized approach to effectively monitor the humoral response to infection, particularly in specific, understudied populations [37]. The impact of this study is amplified because cohort studies of highly vaccinated adults without pre-existing severe health problems who were not hospitalized for COVID-19 are scarce [40,41] and because few COVID-19 studies have reported longitudinal data from sampling of the same individuals over a long period [42].…”

Section: Discussionmentioning

confidence: 99%

“…This work is part of a collective effort and stresses the importance of rapidly developing adaptable, decentralized tests for population-level immune surveillance in response to a pandemic, even before centralized testing is available [37,39]. To our knowledge, no other study has reported such an extensive 18-month longitudinal investigation during the key periods preceding and following the emergence of Omicron in a cohort of highly vaccinated food and retail workers, using both centralized and customized methods to analyze two types of immunoglobulin, three types of epitope, and antigens to three VOC [40,41], [42]. This study will inform strategies and measures to be implemented in the event of a future pandemic.…”

Section: Introductionmentioning

confidence: 99%

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Longitudinal Study on Seroprevalence and Immune Response to SARS-CoV-2 in a Population of Food and Retail Workers Through Transformation of ELISA Datasets

Djaïleb,

Parker,

Lavallée

et al. 2024

Preprint

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Since the onset of the global pandemic caused by the emergence and spread of SARS-CoV-2 in early 2020, numerous studies have been conducted worldwide to understand our immune response to the virus. This study investigates the humoral response elicited by vaccination and by SARS-CoV-2 infection in the poorly studied food and retail workers in the Quebec City area. The 1.5-year study period spans from early 2021, when vaccination became available in this region, to mid-2022, following waves of virulence due to the emergence of the first Omicron variants. Cross-correlated with data on workplace protective measures, pre-existing conditions, activities and other potentially relevant factors, this longitudinal study applies recently developed ELISA data transformation to our dataset to obtain normal distribution. This unlocked the possibility to use the ANOVA-Welsh method for statistical analysis to obtain a statistical perspective of the serological response. Our work allows the identification of factors contributing to statistically relevant differences in the humoral response of the cohort and strengthens the utility of the use of decentralized approaches to serological analysis.

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“…Nonetheless, during SARS-CoV-2 infection, antibody responses are variable and generate controversy in terms of immunity and persistence [ 9 ]. Secondly, it is crucial to determine the timing for antibody maintenance after vaccination or even a natural infection [ 10 , 11 ]. This fact acquired a special relevance given that SARS-CoV-2 vaccines, which have already entered phase III clinical trials, arose as a critical solution [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

A Highly Sensitive Immunoassay for Determination of Immune Response to SARS-CoV-2 in Capillary Blood Samples

et al. 2022

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Throughout the pandemic, serological assays have been revealed as crucial for detecting previous exposures to the virus and determining the timing of antibody maintenance after vaccination or natural infection. This study aimed to develop an optimized enzyme-linked immunosorbent assay (ELISA)-based serology, which could be used in case of reagent shortages, such as that occurred in the beginning of this health emergency. As a result, we present a high-sensitive immunoassay for the determination of IgG levels in venous serum samples, using 2 μg/mL antigen (receptor-binding domain of the spike protein S1) for coating the plate and utilizing human samples at a dilution 1:1000. This method showed non-inferiority features versus a commercial kit, is less expensive, and has a higher spectrophotometric range that allows for a better quantification of the antibody titers. The optical density values before and after heating venous serum samples at 56 °C during 30 min was quite similar, showing that heat inactivation can be used to reduce the biohazardous risks while handling samples. Furthermore, we show that finger-stick capillary blood samples can also serve as a suitable source for IgG detection, bypassing the need for serum isolation and being suitable for point-of-care application (Pearson’s coefficient correlation with capillary serum was 0.95, being statistically significant).

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Vaccine-induced seroconversion in participants in the North Carolina COVID-19 community Research Partnership

Cited by 8 publications

References 12 publications

Utilizing the theory of planned behavior to predict COVID-19 vaccination intention: A structural equational modeling approach

Utilizing the theory of planned behavior to predict COVID-19 vaccination intention: A structural equational modeling approach

Longitudinal Study on Seroprevalence and Immune Response to SARS-CoV-2 in a Population of Food and Retail Workers Through Transformation of ELISA Datasets

A Highly Sensitive Immunoassay for Determination of Immune Response to SARS-CoV-2 in Capillary Blood Samples

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