Vaccine-Induced Thrombotic Thrombocytopenia: Insights from Blood Smear

Zimmermann, S; Federbusch, Martin; Isermann, Berend; Kohli, Shruti

doi:10.1055/a-1681-7286

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…MSM may engage in sexual activity with multiple partners or without protection, placing them at an increased risk of contracting MPX ( 46 ). Consequently, they perceive that the benefits of vaccination outweigh the risks ( 47 ). Moreover, MSM predominantly utilizes social media platforms to seek sexual partners and have extensive and interconnected social networks.…”

Section: Discussionmentioning

confidence: 99%

Willingness to accept monkeypox vaccine and its correlates among men who have sex with men in Southern China: a web-based online cross-sectional study

Huang,

Lin,

Qin

et al. 2024

Front. Public Health

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BackgroundThe May 2022 global outbreak of monkeypox (MPX) poses a threat to the health of men who have sex with men. However, there is limited data on the willingness of MSM to receive monkeypox vaccination in Southern China. This study aimed to assess the knowledge of MPX, concerns regarding MPX, and willingness to receive monkeypox vaccination, as well as their correlates, among MSM in China.MethodsWe conducted a Web-based online survey of MSM in Southern China from August to September 2022. Data were collected on the socio-demographic characteristics, knowledge, worries, concerns regarding MPX and willingness to receive monkeypox vaccination. Multivariate logistic regression was employed to explore the factors associated with willingness to receive monkeypox vaccination.ResultsA total of 1903 participants completed the survey. Among them, approximately 69.9% reported being aware of MPX awareness, 94.1% of the participants supported the promotion of monkeypox vaccination. The majority of participants (91.4%) expressed their willingness to receive monkeypox vaccination. Participants who considered monkeypox vaccination safe [adjusted odds ratio (aOR) = 4.82, 95% CI: 1.35–17.18], agreed on the necessity of government promotion of monkeypox vaccination in China (aOR = 6.03, 95% CI: 1.07–33.93), believed in prioritizing monkeypox vaccination for MSM (aOR = 5.01, 95% CI: 1.10–22.71), and had friends or sexual partners who had already received the monkeypox or smallpox vaccination (aOR = 10.37, 95% CI: 2.11–50.99) are more likely to be vaccinated. Conversely, married individuals (aOR = 0.13, 95% CI: 0.03–0.47), those engaging in anal sex 4–6 times per week in the past 3 months (aOR = 0.26, 95% CI: 0.09–0.77) expressed hesitancy toward monkeypox vaccination.ConclusionThere was a high willingness to receive monkeypox vaccination among MSM in China. The hesitancy toward the monkeypox vaccine can be effectively mitigated by addressing concerns about its safety and potential adverse reactions. Moreover, increasing acceptance of the monkeypox vaccination among MSM and their peers is crucial, as social influence significantly impacts vaccine attitudes and behaviors.

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Section: Discussionmentioning

confidence: 99%

Willingness to accept monkeypox vaccine and its correlates among men who have sex with men in Southern China: a web-based online cross-sectional study

Huang,

Lin,

Qin

et al. 2024

Front. Public Health

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“…The international standardized ratio (INR) and activated partial thromboplastin time (APTT) were mostly within the normal range, and the level of C-reactive protein was always increased [3] , [4] , [5] . Blood smear indicates platelet aggregation, routine blood analyses show increased platelet volume [28] .…”

Section: Clinical Manifestations and Laboratory Testsmentioning

confidence: 99%

SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia

Liu

Shao

Wang

2022

Thrombosis Research

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SARS-CoV-2 vaccines have been carefully developed and significantly alleviate the global pandemic. However, a rare but severe complication after vaccination of adenoviral vector vaccines has attracted worldwide attention. It is characterized by thrombosis at unusual sites (often cerebral or abdominal), thrombocytopenia, and the presence of antibodies against platelet factor 4 (PF4), termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Its pathogenesis is similar to that of heparin-induced thrombocytopenia (HIT). VITT progresses rapidly and has a high mortality rate. Clinicians and the public should raise their vigilance to this disease so that accurate and timely treatment is provided.

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Azd-1222

2022

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Vaccine-Induced Thrombotic Thrombocytopenia: Insights from Blood Smear

Cited by 6 publications

References 3 publications

Willingness to accept monkeypox vaccine and its correlates among men who have sex with men in Southern China: a web-based online cross-sectional study

Willingness to accept monkeypox vaccine and its correlates among men who have sex with men in Southern China: a web-based online cross-sectional study

SARS-CoV-2 vaccine-induced immune thrombotic thrombocytopenia

Azd-1222

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