Vaccine‐preventable severe morbidity and mortality caused by meningococcus and pneumococcus: A population‐based study in France

Lorton, Fleur; Assathiany, R.; Martinot, A.; Bucchia, M.; Roué, Jean‐Michel; Bourgoin, Pierre; Chantreuil, J.; Boussicault, Gérald; Gaillot, T.; Saulnier, J.-P.; Caillon, Jocelyne; Lévy, Corinne; Cohen, Robert; Guen, Christèle Gras‐Le; Launay, Élise

doi:10.1111/ppe.12500

Cited by 17 publications

(9 citation statements)

References 14 publications

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“…A mandatory immunization program is critical to protect infants against potentially life-threatening infections, and its schedule needs to be carefully respected (1), especially for the priming doses (2,3). Experts consider that any delay in these priming doses is dangerous for the infant, whereas a delay of 1 or 2 months may be relativized for boosters (2,4).…”

Section: Introductionmentioning

confidence: 99%

Mandatory Infant Vaccinations in France During the COVID-19 Pandemic in 2020

et al. 2021

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Objectives: To describe changes in the dispensation of 11 mandatory vaccines to infants in France during the COVID-19 pandemic in 2020, considering the priming doses and boosters separately.Methods: With data from the French national health database, all dispensations of priming doses and boosters of 11 mandatory vaccines [penta/hexavalent, measles mumps rubella (MMR), meningococcal conjugate type-C (Men-C-C), 13-valent pneumococcal conjugate (PCV13)] for infants ≤24 months old were aggregated by 4-week periods in 2020. Expected counts in 2020 were estimated according to counts in 2019 weighted by a ratio considering the level of vaccine dispensation before the pandemic onset in 2020. Relative differences (RDs) and their 95% confidence intervals (CIs) were computed to compare the observed and expected counts during the first and second lockdown and the period in between.Results: During the first 4 weeks of the first lockdown, as compared with the expected numbers, the observed priming dose counts substantially decreased [RD: from −5.7% (95% CI −6.1; −5.2) for penta/hexavalent to −25.2% (95% CI −25.6; −24.8) for MMR], as did the booster counts [RD: from −15.3% (95% CI −15.9; −14.7) for penta/hexavalent to −20.7% (95% CI −21.3; −20.2) for Men-C-C]. Counts for priming doses and boosters remained slightly below the expected numbers after the lockdown. During 2020, MMR priming doses and the Men-C-C booster had the greatest shortfalls (N = 84,893 and 72,500, respectively).Conclusions: This study provides evidence of a lack of vaccination catch-up after the first lockdown and a persistent shortfall in infant vaccination after the first 10 months of the COVID-19 pandemic in France, especially for the MMR priming doses and Men-C-C booster.

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Section: Introductionmentioning

confidence: 99%

Mandatory Infant Vaccinations in France During the COVID-19 Pandemic in 2020

et al. 2021

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“…They described vaccines as safe and effective drugs. Numerous scientific studies corroborated their statements (23,24).…”

Section: Discussionmentioning

confidence: 65%

Image of the new vaccination obligation through the media

Mitilian

Malli

Verger

2020

Vaccine

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“…Unfortunately, we had demonstrated that lack of on-time vaccination was highly prevalent in this population. 28 Finally, an important point of this finding was that the primary outcome of future studies assessing the impact of care on child outcome should not be a composite of mortality and morbidity because this could lead to the loss of any significant association. 5,54 Analyses of the determinants of the quality of care allowed us to identify several possible targets for corrective action.…”

Section: Discussionmentioning

confidence: 99%

Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children

Lorton

Martinot²,

Assathiany

et al. 2022

JAMA Netw Open

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Key Points Question What are the prevalence, characteristics, and determinants of suboptimal care in the initial management of community-onset severe bacterial infections in children? Findings In this cohort study that included 259 children, suboptimal care before pediatric intensive care unit admission was frequent and was associated with severe sequelae in children with a community-onset severe bacterial infection. The youngest children and those initially cared for by a primary care physician were at increased risk of suboptimal care. Meaning These findings suggest that medical care could be optimized, especially for young children, by improving the preparedness of primary care physicians.

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Vaccine‐preventable severe morbidity and mortality caused by meningococcus and pneumococcus: A population‐based study in France

Abstract: Mortality and morbidity rates related to vaccine-preventable meningococcal or pneumococcal infection could be reduced by one quarter with better implementation of immunisation programs. Such information could help enhance the perception of vaccine benefits and fight vaccine hesitancy.

Cited by 17 publications

References 14 publications

Mandatory Infant Vaccinations in France During the COVID-19 Pandemic in 2020

Mandatory Infant Vaccinations in France During the COVID-19 Pandemic in 2020

Image of the new vaccination obligation through the media

Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children

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