Vaccine-Preventable Viral Infections in Pediatric Patients Post Renal Transplant: A Report From the North American Pediatric Renal Transplant Cooperative Study (Naprtcs). 2146

Furth, Susan L.; Neu, Alicia M.; Bock, Glenn H.; Sullivan, Emily; Fivush, Barbara A.

doi:10.1203/00006450-199604001-02170

Cited by 17 publications

(25 citation statements)

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“…The majority of previous reports focused on the safety and short-term immunogenicity [28,29,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55], whereas data on the long-term clinical efficacy are rare [21,27,56].…”

Section: The Risk Of Vaccine-preventable Diseasesmentioning

confidence: 97%

“…Children with CRF generally produce detectable and protective serum antibodies to primary vaccinations with killed or component vaccines and live virus vaccines, as listed in Table 1: diphtheria [38,40], tetanus [38,40], pertussis [38], inactivated poliomyelitis [38,42], hepatitis B [27,43,44,45], measles [27,46,47], varicella [21,27,28,29,56], influenza [48,49,50], Hemophilus influenzae type b [51,52], and S. pneumoniae [27,53,54,55]. Also, administration of boosters after RTPL induced a significant antibody response: diphtheria [39,41] and tetanus [39,41].…”

Section: Immunogenicitymentioning

confidence: 99%

“…Most reports are limited and do not provide precise information regarding the specific pathogens. Thus, epidemiological data on incidence and prevalence of vaccine-preventable infections in children with CRF are scarce [21,27,28,29,30,31].…”

Section: The Risk Of Vaccine-preventable Diseasesmentioning

confidence: 99%

“…Live virus vaccines have also been documented as safe in children on conservative treatment or on dialysis [21,27,28,29,46,47,56]. Most guidelines do not recommend live virus vaccines after RTPL.…”

Section: Safetymentioning

confidence: 99%

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Immunization in children with chronic renal failure: a practical approach

Neuhaus¹

2004

Pediatr Nephrol

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The prevention of systemic viral and bacterial infections by effective vaccination represents an essential task of pediatric nephrologists caring for children with chronic renal failure (CRF) undergoing renal transplantation (RTPL) with life-long immunosuppression. This review addresses three issues: risk of vaccine-preventable diseases, safety, immunogenicity, and clinical efficacy of available vaccines, and implementation of immunization guidelines. Infections (including vaccine-preventable infections) represent the leading cause of morbidity and mortality in children on dialysis and after RTPL. Vaccination in children with CRF and after RTPL is safe and does not cause reactivation of an immune-related renal disease or rejection after RTPL. Children with CRF generally produce protective serum antibodies to primary vaccinations with killed or component vaccines and live virus vaccines; some children on dialysis and after RTPL may not respond optimally, requiring repeated vaccination. Proof of vaccine efficacy is absence of disease, which can only be confirmed in large cohort studies. A few observational studies provide evidence that vaccination has contributed significantly, at least in the western hemisphere, to the low prevalence of vaccine-preventable diseases among children with CRF. Close cooperation between the local pediatrician/practitioner and the pediatric nephrologist is essential for successful implementation of the vaccination schedule.

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Section: The Risk Of Vaccine-preventable Diseasesmentioning

confidence: 97%

Section: Immunogenicitymentioning

confidence: 99%

Section: The Risk Of Vaccine-preventable Diseasesmentioning

confidence: 99%

Section: Safetymentioning

confidence: 99%

See 2 more Smart Citations

Immunization in children with chronic renal failure: a practical approach

Neuhaus¹

2004

Pediatr Nephrol

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“…Varicella is rare in adult SOT recipients, but can be devastating, with visceral involvement, severe skin disease, and disseminated intravascular coagulation. (14)(15)(16)(17)(18)(19) Herpes zoster is a frequent infectious complication in SOT recipients with an incidence of approximately 8-11% during the first four years post transplant. (20)(21)(22) Invasive disease and dissemination similar to that seen in primary VZV infection are uncommon but have been reported in SOT and other immunocompromised populations, and level of immunosuppression may alter the risk of developing these complications.…”

mentioning

confidence: 99%