Vaccine strain of O/ME-SA/Ind-2001e of foot-and-mouth disease virus provides high immunogenicity and broad antigenic coverage

Lee, Gyeongmin; Hwang, Ji-Hyeon; Park, Jong Hyeon; Lee, Min Ja; Kim, Su-Mi

doi:10.1016/j.antiviral.2020.104920

Cited by 17 publications

(17 citation statements)

References 39 publications

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“…Currently, three topotypes of serotype O viruses (SEA, Cathay and ME-SA) are circulating in the region ( Table 1 ), although historically SEA countries were home to SEA and Cathay topotype viruses. The O/ME-SA/PanAsia strain spread to SEA countries in early 2000, causing devastating economic consequences [ 12 , 13 , 14 ]. One decade later, in early 2010, another ME-SA strain (O/Ind-2001) from the Indian subcontinent spread to these countries [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…Thus, it appears that the existing v / s are broadly cross-reactive and can provide protection against the circulating topotypes, except Cathay viruses, as demonstrated previously using O 1 /Campos v / s [ 24 , 25 ]. Several studies, mainly from South Korea, have reported the suitability of new putative strains for use in both pigs and cattle in their control programs [ 13 , 14 , 26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, although these v / s did not provide in vitro protection, it is possible that some protection could be observed in vivo, especially when high-antigen-payload vaccines are used. Indeed, a recent study involving a high-potency O/SKR/BOEUN/2017 vaccine (12.5 PD 50 ) exhibited in vitro protection against Cathay virus [ 13 , 14 ]. In addition, a better in vivo correlation protection has been established, combining both virus neutralization test results and the T-cell responses [ 34 ], which was out of the scope of this study.…”

Section: Resultsmentioning

confidence: 99%

“…Along with three usual strains O/SEA/Mya-98, O/Middle East-South Asia (ME-SA)/PanAsia and Cathay, a new O/ME-SA/Ind-2001 lineage, has been circulating in this region since 2015 and, have now spread to most of the SEA countries ( Table 1 ). Although vaccination is the key to controlling FMD, the available vaccines are not able to provide enough cross-protection as outbreaks have been still seen in South Korea since 2010 even with repeated vaccinations [ 12 , 13 , 14 ]. Therefore, a regular vaccine-matching test of circulating viruses with the existing vaccines in antigenic reserves is required, and if necessary, a broadly cross-reacting vaccine strain should be used in vaccination programs.…”

Section: Introductionmentioning

confidence: 99%

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Molecular Basis of Antigenic Drift in Serotype O Foot-and-Mouth Disease Viruses (2013–2018) from Southeast Asia

Upadhyaya

Mahapatra

Mioulet

et al. 2021

Viruses

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Foot and mouth disease (FMD) is a highly contagious disease of cloven-hoofed animals with serious economic consequences. FMD is endemic in Southeast Asia (SEA) and East Asia (EA) with the circulation of multiple serotypes, posing a threat to Australia and other FMD-free countries. Although vaccination is one of the most important control measures to prevent FMD outbreaks, the available vaccines may not be able to provide enough cross-protection against the FMD viruses (FMDVs) circulating in these countries due to the incursion of new lineages and sub-lineages as experienced in South Korea during 2010, a FMD-free country, when a new lineage of serotype O FMDV (Mya-98) spread to the country, resulting in devastating economic consequences. In this study, a total of 62 serotype O (2013–2018) viruses selected from SEA and EA countries were antigenically characterized by virus neutralization tests using three existing (O/HKN/6/83, O/IND/R2/75 and O/PanAsia-2) and one putative (O/MYA/2009) vaccine strains and full capsid sequencing. The Capsid sequence analysis revealed three topotypes, Cathay, SEA and Middle East-South Asia (ME-SA) of FMDVs circulating in the region. The vaccines used in this study showed a good match with the SEA and ME-SA viruses. However, none of the recently circulating Cathay topotype viruses were protected by any of the vaccine strains, including the existing Cathay topotype vaccine (O/HKN/6/83), indicating an antigenic drift and, also the urgency to monitor this topotype in the region and develop a new vaccine strain if necessary, although currently the presence of this topotype is mainly restricted to China, Hong Kong, Taiwan and Vietnam. Further, the capsid sequences of these viruses were analyzed that identified several capsid amino acid substitutions involving neutralizing antigenic sites 1, 2 and 5, which either individually or together could underpin the observed antigenic drift.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Basis of Antigenic Drift in Serotype O Foot-and-Mouth Disease Viruses (2013–2018) from Southeast Asia

Upadhyaya

Mahapatra

Mioulet

et al. 2021

Viruses

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“…FMDV O/SKR/Boeun/2017 (O BE) [15], which is a Korean isolate, was used in this study. FMDV O BE was inoculated in BHK21 suspension cells at a multiplicity of infection of 0.005 and incubated at 37 • C in a 5% CO 2 shaking incubator at 110 rpm.…”

Section: Preparation Of Fmdv Samplesmentioning

confidence: 99%

Validation of Pretreatment Methods for the In-Process Quantification of Foot-and-Mouth Disease Vaccine Antigens

Kim¹,

Park²,

Park³

et al. 2021

Vaccines

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Foot-and-mouth disease (FMD), caused by the FMD virus (FMDV), is controlled by vaccine policy in many countries. For vaccine potency, the content of intact virus particles (146S antigens) is critical, and the sucrose density gradient (SDG) fractionation is the gold standard for the quantification of 146S antigens. However, this method has several drawbacks. Although size-exclusion high-performance liquid chromatography (SE-HPLC) was introduced to replace the classic method, its application is generally confined to purified samples owing to the interfering signals. Therefore, we aimed to develop optimal pretreatment methods for SE-HPLC quantification in less purified samples. Crude virus infection supernatant (CVIS) and semi-purified samples with PEG precipitation (PEG-P) were used. Chloroform pretreatment was essential to remove a high level of non-specific signals in CVIS, whereas it caused loss of 146S antigens without the distinctive removal of non-specific signals in PEG-P. Benzonase pretreatment was required to improve the resolution of the target peak in the chromatogram for both CVIS and PEG-P. Through spiking tests with pure 146S antigens, it was verified that the combined pretreatment with chloroform and benzonase was optimal for the CVIS, while the sole pretreatment of benzonase was beneficial for PEG-P.

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Porcine interferon-α linked to the porcine IgG-Fc induces prolonged and broad-spectrum antiviral effects against foot-and-mouth disease virus

Lee,

Kim,

Kang

et al. 2024

Antiviral Research

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Vaccine strain of O/ME-SA/Ind-2001e of foot-and-mouth disease virus provides high immunogenicity and broad antigenic coverage

Cited by 17 publications

References 39 publications

Molecular Basis of Antigenic Drift in Serotype O Foot-and-Mouth Disease Viruses (2013–2018) from Southeast Asia

Molecular Basis of Antigenic Drift in Serotype O Foot-and-Mouth Disease Viruses (2013–2018) from Southeast Asia

Validation of Pretreatment Methods for the In-Process Quantification of Foot-and-Mouth Disease Vaccine Antigens

Porcine interferon-α linked to the porcine IgG-Fc induces prolonged and broad-spectrum antiviral effects against foot-and-mouth disease virus

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