2016
DOI: 10.1016/j.ijtb.2016.02.005
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Vaccines against tuberculosis: A review

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Cited by 11 publications
(6 citation statements)
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“…186,187 Further, Mtb72F has also been shown to stimulate T cell proliferation and IFN-g secretion in PPD positive healthy individuals. 187,188 Currently, the safety and immunogenicity of Mtb72F vaccine have been evaluated in some Phase II clinical studies performed in healthy PPD-positive adults in the Philippines, 189 in healthy HIV-negative adolescents in South Africa, 190 and in adults in Taiwan and Estonia. 191 All three Phase II clinical trials showed similar safety profiles and antibody responses, and indicated that this vaccine could induce strong CD4 C T cell immune responses, rather than CD8 C T cell responses.…”
Section: Mtb72fmentioning
confidence: 99%
See 1 more Smart Citation
“…186,187 Further, Mtb72F has also been shown to stimulate T cell proliferation and IFN-g secretion in PPD positive healthy individuals. 187,188 Currently, the safety and immunogenicity of Mtb72F vaccine have been evaluated in some Phase II clinical studies performed in healthy PPD-positive adults in the Philippines, 189 in healthy HIV-negative adolescents in South Africa, 190 and in adults in Taiwan and Estonia. 191 All three Phase II clinical trials showed similar safety profiles and antibody responses, and indicated that this vaccine could induce strong CD4 C T cell immune responses, rather than CD8 C T cell responses.…”
Section: Mtb72fmentioning
confidence: 99%
“…These clinical trials yielded similar results, in that H4:IC31 had an acceptable safety profile in human beings and induced IFN-g production and a multifunctional CD4 C Th1 response. 188,197 Additionally, a Phase II clinical trial has been completed by Aeras in healthy adolescents in South Africa (ClinicalTrials.gov Identifier: NCT02075203). The results demonstrated that this vaccine was safe and immunogenic, and indicated that a 15 mg dose induced the optimal immune response.…”
Section: Mtb72fmentioning
confidence: 99%
“…Several phase I clinical trials evaluating the safety and immunogenicity of H4:IC31 have been conducted in TB-negative, HIV-negative, BCG-unvaccinated adults in Switzerland (NCT02420444), in TB-negative, HIV-negative, BCG-vaccinated adults in South Africa (NCT02109874), in HIV-negative, BCG-vaccinated adults in Sweden (NCT02066428) and Finland (NCT02074956), and in HIV-uninfected, HIV-unexposed, BCG-primed infants in South Africa (NCT01861730). These clinical trials have produced similar results, demonstrating that H4:IC31 is safe in humans and induces IFN-γ production and multifunctional CD4 + Th1 responses [ 87 , 150 , 151 ]. In 2020, a phase 1b randomized clinical trial (NCT02378207) was conducted in Cape Town, South Africa.…”
Section: The Clinical Pipeline Of Tb Vaccinesmentioning
confidence: 85%
“…Therapeutic vaccines shed light on TB control by inducing antigen specific immune responses against Mtb in vivo (8), and Mtb potent antigen encoding genes are delivered into host cells via plasmid, adenovirus or lentivirus for in vivo gene expression (9,10). As a novel immunotherapy strategy, therapeutic vaccine has been successful for TB control not only in latent TB infection model but also in acute infection model (11,12).…”
Section: Tuberculosis (Tb) a Worldwide Infectious Disease Caused Bymentioning
confidence: 99%